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Mims' Medical Microbiology E-Book

Vörumerki: Elsevier
Vörunúmer: 9780702072024
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Mims' Medical Microbiology E-Book

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Efnisyfirlit

  • Cover image
  • Title Page
  • Table of Contents
  • Copyright
  • Foreword by Cedric Mims
  • Preface to the sixth edition
  • Acknowledgements
  • A contemporary approach to microbiology
    • Introduction
    • The Context for Contemporary Medical Microbiology
    • Microbiology Past, Present and Future
    • The Approach Adopted in This Book
  • Section 1 The Adversaries – Pathogens
    • Introduction
    • 1 Pathogens as parasites
      • The Varieties of Pathogens
      • Living Inside or Outside Cells
      • Systems of Classification
    • 2 The bacteria
      • Structure
      • Nutrition
      • Growth and Division
      • Gene Expression
      • Survival Under Adverse Conditions
      • Mobile Genetic Elements
      • Mutation and Gene Transfer
      • The Genomics of Medically Important Bacteria
    • 3 The viruses
      • Major Groups of Viruses
      • Infection of Host Cells
      • Replication
      • Outcome of Viral Infection
    • 4 The fungi
      • Major Groups of Disease-Causing Fungi
    • 5 The protozoa
    • 6 The helminths
      • Life Cycles
      • Helminths and Disease
    • 7 The arthropods
    • 8 Prions
      • ‘Rogue Protein’ Pathogenesis
      • Development, Transmission and Diagnosis of Prion Diseases
      • Prevention and Treatment of Prion Diseases
    • 9 The host–parasite relationship
      • The Microbiota and Microbiome
      • Symbiotic Associations
      • The Characteristics of Parasitism
      • The Evolution of Parasitism
  • Section 2 The Adversaries – Host Defences
    • Introduction
    • 10 The innate defences of the body
      • Defences Against Entry Into the Body
      • Defences Once the Microorganism Penetrates the Body
    • 11 Adaptive immune responses bring specificity
      • Lymphoid Tissues Primary and Secondary
      • Secondary Lymphoid Organs
      • Subsets of T Cells
      • Antibody Structure and Function
      • Recirculation of T and B Cells
    • 12 Cooperation leads to effective immune responses
      • Cooperation Means Greater Efficiency
      • Opsonization by Antibody Enhances Phagocytosis and Leads to Complement Activation
      • Beneficial Inflammatory Reactions Can Also Be Enhanced by Antibodies
      • Activation of T Cells Involves Antigen-Presenting Cells and Additional Co-Stimulatory Signals
      • Clonal Expansion
      • Antibody Production Involves a Series of Steps Within the Germinal Centre
      • Cytokines Play an Important Part in These Cell–Cell Interactions
      • Immunological Memory Enables a Second Infection With the Same Microbe to Be Dealt With More Effectively
      • Armies Must Be Kept Under Control
  • Section 3 The Conflicts
    • Introduction
    • 13 Background to the infectious diseases
      • Host–Parasite Relationships
      • Causes of Infectious Diseases
      • The Biological Response Gradient
    • 14 Entry, exit and transmission
      • Sites of Entry
      • Exit and Transmission
      • Types of Transmission Between Humans
      • Transmission From Animals
    • 15 Immune defences in action
      • Complement
      • Acute Phase Proteins and Pattern Recognition Receptors
      • Fever
      • Natural Killer Cells
      • Phagocytosis
      • Cytokines
      • Antibody-Mediated Immunity
      • Cell-Mediated Immunity
      • Recovery From Infection
    • 16 Spread and replication
      • Features of Surface and Systemic Infections
      • Mechanisms of Spread Through the Body
      • Genetic Determinants of Spread and Replication
      • Other Factors Affecting Spread and Replication
    • 17 Parasite survival strategies and persistent infections
      • Parasite Survival Strategies
      • Concealment of Antigens
      • Antigenic Variation
      • Immunosuppression
      • Persistent Infections
    • 18 Pathological consequences of infection
      • Pathology Caused Directly by Microorganisms
      • Diarrhoea
      • Pathological Activation of Natural Immune Mechanisms
      • Pathological Consequences of the Immune Response
      • Skin Rashes
      • Viruses and Cancer
  • Section 4 Clinical Manifestation and Diagnosis of Infections by Body System
    • Introduction
      • The Clinical Manifestations of Infection
    • 19 Upper respiratory tract infections
      • Rhinitis
      • Pharyngitis and Tonsillitis
      • Parotitis
      • Otitis and Sinusitis
      • Acute Epiglottitis
      • Oral Cavity Infections
    • 20 Lower respiratory tract infections
      • Laryngitis and Tracheitis
      • Diphtheria
      • Whooping Cough
      • Acute Bronchitis
      • Acute Exacerbations of Chronic Bronchitis
      • Bronchiolitis
      • Respiratory Syncytial Virus (RSV) Infection
      • Hantavirus Pulmonary Syndrome (HPS)
      • Pneumonia
      • Bacterial Pneumonia
      • Viral Pneumonia
      • Parainfluenza Virus Infection
      • Adenovirus Infection
      • Human Metapneumovirus Infection
      • Human Bocavirus Infection
      • Influenza Virus Infection
      • Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome Coronavirus Infections
      • Measles Virus Infection
      • Cytomegalovirus Infection
      • Tuberculosis
      • Cystic Fibrosis
      • Lung Abscess
      • Fungal Infections
      • Protozoal Infections
    • 21 Urinary tract infections
      • Acquisition and Aetiology
      • Pathogenesis
      • Clinical Features and Complications
      • Laboratory Diagnosis
      • Treatment
      • Prevention
    • 22 Sexually transmitted infections
      • Stis and Sexual Behaviour
      • Syphilis
      • Gonorrhoea
      • Chlamydial Infection
      • Other Causes of Inguinal Lymphadenopathy
      • Mycoplasmas and Non-Gonococcal Urethritis
      • Other Causes of Vaginitis and Urethritis
      • Genital Herpes
      • Human Papillomavirus Infection
      • Human Immunodeficiency Virus
      • Opportunist Stis
      • Arthropod Infestations
    • 23 Gastrointestinal tract infections
      • Diarrhoeal Diseases Caused by Bacterial or Viral Infection
      • Food Poisoning – Bacterial Toxin-Associated Diarrhoea
      • Viral Causes of Diarrhoea
      • Helicobacter Pylori and Gastric Ulcer Disease
      • Parasites and the Gastrointestinal Tract
      • Systemic Infection Initiated in the Gastrointestinal Tract
    • 24 Obstetric and perinatal infections
      • Infections Occurring in Pregnancy
      • Congenital Infections
      • Infections Occurring Around the Time of Birth
    • 25 Central nervous system infections
      • Invasion of the Central Nervous System
      • The Body's Response to Invasion
      • Meningitis
      • Encephalitis
      • Neurological Diseases of Possible Viral Aetiology
      • Spongiform Encephalopathies Caused by Scrapie-Type Agents
      • CNS Disease Caused by Parasites
      • Brain Abscesses
      • Tetanus and Botulism
    • 26 Infections of the eye
      • Conjunctivitis
      • Infection of the Deeper Layers of the Eye
    • 27 Infections of the skin, soft tissue, muscle and associated systems
      • Bacterial Infections of Skin, Soft Tissue and Muscle
      • Mycobacterial Diseases of the Skin
      • Fungal Infections of the Skin
      • Parasitic Infections of the Skin
      • Mucocutaneous Manifestations of Viral Infections
      • Smallpox Virus Infection
      • Measles Virus Infection
      • Rubella Virus Infection
      • Other Maculopapular Rashes Associated With Travel-Related Infections
      • Other Infections Producing Skin Lesions
      • Kawasaki Syndrome
      • Viral Infections of Muscle
      • Parasitic Infections of Muscle
      • Joint and Bone Infections
      • Infections of the Haemopoietic System
    • 28 Vector-borne infections
      • Arbovirus Infections
      • Infections Caused by Rickettsiae
      • Borrelia Infections
      • Protozoal Infections
      • Helminth Infections
    • 29 Multisystem zoonoses
      • Arenavirus Infections
      • Haemorrhagic Fever With Renal Syndrome (HFRS)
      • Ebola and Marburg Haemorrhagic Fevers
      • Crimean–Congo Haemorrhagic Fever, a Tick-Borne Virus
      • Q Fever
      • Anthrax
      • Plague
      • Yersinia Enterocolitica Infection
      • Tularaemia
      • Pasteurella Multocida Infection
      • Leptospirosis
      • Rat-Bite Fever
      • Brucellosis
      • Helminth Infections
    • 30 Fever of unknown origin
      • Definitions of Fever of Unknown Origin
      • Causes of FUO
      • Investigation of Classic FUO
      • Treatment of FUO
      • FUO in Specific Patient Groups
      • Infective Endocarditis
    • 31 Infections in the compromised host
      • The Compromised Host
      • Infections of the Host With Deficient Innate Immunity Due to Physical Factors
      • Infections Associated With Secondary Adaptive Immunodeficiency
      • Other Important Opportunist Pathogens
  • Section 5 Diagnosis and Control
    • Introduction
    • 32 Diagnosis of infection and assessment of host defence mechanisms
      • Aims of the Clinical Microbiology Laboratory
      • Specimen Processing
      • Cultivation (Culture) of Microorganisms
      • Identification of Microorganisms Grown in Culture
      • Non-Cultural Techniques for the Laboratory Diagnosis of Infection
      • Antibody Detection Methods for the Diagnosis of Infection
      • Assessment of Host Defence Systems
      • Putting It All Together: Detection, Diagnosis and Epidemiology
    • 33 Epidemiology and control of infectious diseases
      • Outcome Measurements
      • Types of Epidemiological Studies
      • Transmission of Infectious Disease
      • Vaccine Efficacy
    • 34 Attacking the enemy
      • Selective Toxicity
      • Discovery and Design of Antimicrobial Agents
      • Classification of Antibacterial Agents
      • Resistance to Antibacterial Agents
      • Classes of Antibacterial Agents
      • Inhibitors of Cell Wall Synthesis
      • Inhibitors of Protein Synthesis
      • Inhibitors of Nucleic Acid Synthesis
      • Antimetabolites Affecting Nucleic Acid Synthesis
      • Other Agents That Affect DNA
      • Inhibitors of Cytoplasmic Membrane Function
      • Urinary Tract Antiseptics
      • Antituberculosis Agents
      • Antibacterial Agents in Practice
      • Antibiotic Assays
      • Antiviral Therapy
      • Antifungal Agents
      • Antiparasitic Agents
      • Control by Chemotherapy Versus Vaccination
      • Control Versus Eradication
      • Use and Misuse of Antimicrobial Agents
    • 35 Protecting the host
      • Vaccination – a Four Hundred Year History
      • Aims of Vaccination
      • Vaccines Can Be of Different Types
    • 36 Active, passive and adoptive immunotherapy
      • Adoptive Immunotherapy
      • Passive Immunotherapy
      • Non-Specific Cellular Immunostimulation
      • Correction of Host Immunodeficiency
      • Probiotics
    • 37 Infection control
      • Common Hospital Infections
      • Important Causes of Hospital Infection
      • Sources and Routes of Spread of Hospital Infection
      • Host Factors and Hospital Infection
      • Consequences of Hospital Infection
      • Prevention of Hospital Infection
      • Investigating Healthcare-Associated Infection
      • Sterilization and Disinfection
  • Bibliography – list of useful websites
    • Useful Websites
  • Pathogen parade
    • Viruses
    • Bacteria
    • Fungi
    • Protozoa
    • Helminths
  • Vaccine parade
  • Index

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Vörumerki: Elsevier
Vörunúmer: 9780702072024
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