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Introduction to the Pharmaceutical Sciences: An Integrated Approach

Vörumerki: Lippincott
Vörunúmer: 9781451167504
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Introduction to the Pharmaceutical Sciences: An Integrated Approach

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Efnisyfirlit

  • Introduction to the Pharmaceutical Sciences: An Integrated Approach, Second Edition
  • Copyright
  • Preface
  • Acknowledgments
  • Contents
  • Additional Resources
  • Chapter 1: Introduction
    • What Is a Drug?
    • How Do Drugs Work?
    • How Are Drugs Designed?
    • How Are Drugs Administered?
    • How Are Drugs Transported in the Body?
    • How Are Drugs Used Clinically in Patients?
    • How Do Genetic Factors Affect Drug Therapy?
    • How Are New Drugs Developed and Approved for Marketing?
    • Concluding Remarks
  • Part I: Drug Chemistry
    • Chapter 2: Drugs and Their Targets
      • Targets and Biological Activity
      • Binding to the Target
      • Physicochemical Properties of Drugs
      • Structure–Activity Relationships
      • Key Concepts
      • Review Questions
      • Practice Problems
      • Additional Readings
    • Chapter 3: Ionization of Drugs
      • Electrolytes and Nonelectrolytes
      • Importance of Ionization of Weak Electrolytes
      • Water as a Solvent
      • Strong Acids and Bases
      • Weak Acids and Bases
      • Salts of Weak Acids and Bases
      • Ionization and pH
      • Ionization in Unbuffered Solutions
      • Compounds with Multiple Ionizable Groups
      • Key Concepts
      • Review Questions
      • Practice Problems
      • Additional Readings
    • Chapter 4: Solubility and Lipophilicity
      • Solubility Principles
      • The Solvent
      • Water Solubility
      • Lipophilicity
      • Amphiphilicity
      • Key Concepts
      • Review Questions
      • Practice Problems
      • Additional Readings
  • Part II: Drug Delivery
    • Chapter 5: Transport Across Biological Barriers
      • Transport Across the Cell Membrane
      • Transport Across a Tissue
      • Multiple Transport Pathways
      • Key Concepts
      • Review Questions
      • Additional Readings
    • Chapter 6: Drug Absorption
      • Systemic Administration
      • Systemic Absorption of Macromolecular Drugs
      • Local Administration
      • Key Concepts
      • Review Questions
      • Additional Readings
    • Chapter 7: Drug Delivery Systems
      • Dosage Forms
      • Drug Release and Dissolution
      • Approaches to Drug Delivery
      • Drug Stability
      • Delivery of Macromolecular Drugs
      • Key Concepts
      • Review Questions
      • Additional Readings
  • Part III: Drug Disposition
    • Chapter 8: Drug Distribution
      • The Circulatory System
      • Drug Distribution Processes
      • Volume of Distribution
      • Key Concepts
      • Review Questions
      • Practice Problems
      • Additional Readings
    • Chapter 9: Drug Excretion
      • Excretion by the Kidneys
      • Excretion by the Liver
      • Excretion by Other Organs
      • Key Concepts
      • Review Questions
      • Practice Problems
      • Additional Readings
    • Chapter 10: Drug Metabolism
      • Excretion or Metabolism?
      • Drugs, Metabolites, and Enzymes
      • Kinetics of Drug Metabolism
      • Types of Drug Metabolism Reactions
      • Sites of Metabolism
      • Total Body Clearance
      • Factors Altering Drug Metabolism
      • Key Concepts
      • Review Questions
      • Practice Problems
      • Additional Readings
    • Chapter 11: Pharmacokinetic Concepts
      • Pharmacokinetics and Pharmacodynamics
      • Drug Concentrations in Body Fluids
      • Plasma Level Curves
      • Pharmacokinetic Features of a Plasma Level Curve
      • Relationship Between Pharmacokinetics and Pharmacodynamics
      • Pharmacological Features of a Plasma Level Curve
      • Multiple Dosing
      • Key Concepts
      • Review Questions
      • Practice Problems
      • Additional Readings
  • Part IV: Drug Action
    • Chapter 12: Ligands and Receptors
      • The Signaling Process
      • Endogenous Ligands
      • Specificity of Actions
      • Receptors
      • Receptor Structure and Classification
      • Modulation of Ligand–Receptor Interactions
      • Key Concepts
      • Review Questions
      • Additional Readings
    • Chapter 13: Mechanisms of Drug Action
      • Theory of Drug Action
      • Quantitation of Drug–Receptor Interactions
      • Mechanisms of Antagonism
      • Stereoselectivity in Drug Action
      • Interaction of Drugs with Enzymes
      • Nonreceptor-Based Drug Action
      • Key Concepts
      • Review Questions
      • Additional Readings
    • Chapter 14: Dose–Response Relationships
      • Concentration–Response Relationships
      • Dose–Response Relationships
      • Dose-Related Selectivity and Toxicity
      • Key Concepts
      • Review Questions
      • Additional Readings
  • Part V: Drug Therapy
    • Chapter 15: Therapeutic Variability
      • Types of Therapeutic Variability
      • Drug Compliance
      • Individualization of Therapy
      • Key Concepts
      • Review Questions
      • Additional Readings
    • Chapter 16: Drug Interactions
      • Drug–Drug Interactions
      • Food–Drug Interactions
      • Drug–Herbal Interactions
      • Dealing with Interactions
      • Key Concepts
      • Review Questions
      • Additional Readings
    • Chapter 17: Pharmacogenomics
      • Review of Genetics
      • Genetic Variation and Disease
      • Genetic Variation and Response to Drugs
      • Clinical Applications of Pharmacogenomics
      • Proteomics
      • Promise of Pharmacogenomics
      • Key Concepts
      • Review Questions
      • Additional Readings
  • Part VI: Special Topics
    • Chapter 18: Biopharmaceutical Drugs
      • Biotechnology and Genetic Engineering
      • Advantages of the Biopharmaceutical Approach
      • Types of Biopharmaceutical Drugs
      • Formulation of Biopharmaceutical Drugs
      • Stability of Biopharmaceutical Products
      • ADME of Biopharmaceutical Drugs
      • Pharmacological Considerations of Biopharmaceutical Drugs
      • Opportunities and Limitations of Biopharmaceuticals
      • Nucleic Acid-Based Therapeutics
      • Gene Therapy
      • Key Concepts
      • Review Questions
      • Additional Readings
    • Chapter 19: Drug Discovery and Approval
      • The FDA
      • New Drug Development
      • Generic Drug Development and Approval
      • Pharmacogenomics in Drug Development
      • Over-the-Counter Drugs
      • Key Concepts
      • Review Questions
      • Additional Readings
  • Index

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Vörumerki: Lippincott
Vörunúmer: 9781451167504
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