1. Bækur og afþreying
  2. Bækur og kort
  3. Rafbækur
  4. Heilbrigðisvísindi
  5. Læknisfræði

Aulton's Pharmaceutics E-Book

Veldu vöru

Rafræn bók. Uppl. sendar á netfangið þitt eftir kaup
Rafbók til leigu í 1 ár. Útgáfa: 5
Fá vöru senda með tölvupósti

Efnisyfirlit

  • Cover image
  • Title Page
  • Table of Contents
  • Copyright
  • Preface
  • Contributors
  • Acknowledgements
  • What is ‘pharmaceutics’?
  • 1 Design of dosage forms
    • Principles of dosage form design
    • Biopharmaceutical aspects of dosage form design
    • Drug factors in dosage form design
    • Therapeutic considerations in dosage form design
    • Summary
    • Bibliography
  • Part 1 Scientific principles of dosage form design
    • 2 Dissolution and solubility
      • Introduction
      • Definition of terms
      • Process of dissolution
      • Dissolution rates of solids in liquids
      • Solubility
      • Summary
      • Reference
      • Bibliography
    • 3 Properties of solutions
      • Introduction
      • Types of solution
      • Ionization of solutes
      • Colligative properties
      • Diffusion in solution
      • Summary
      • Bibliography
    • 4 Surfaces and interfaces
      • Introduction
      • Surface tension
      • Solid wettability
      • Adsorption at interfaces
      • Solid–vapour adsorption isotherms
      • Interactions between powders and water vapour
      • Inverse phase gas chromatography (IGC)
      • References
    • 5 Disperse systems
      • Introduction
      • Colloids
      • Gels
      • Surface-active agents
      • Coarse disperse systems
      • References
      • Bibliography
    • 6 Rheology
      • Viscosity, rheology and the flow of fluids
      • Newtonian fluids
      • Non-Newtonian fluids
      • The applications of rheology in pharmaceutical formulation
      • References
      • Bibliography
    • 7 Kinetics
      • Introduction
      • Rate laws and order of reaction
      • Complex reactions
      • The Michaelis–Menten equation
      • Effect of temperature on reaction rate
      • Summary
      • Bibliography
  • Part 2 Particle science and powder technology
    • 8 Solid-state properties
      • Solid state
      • Crystallization
      • Polymorphism
      • Hydrates and solvates
      • Amorphous state
      • Crystal habit
      • Surface nature of particles
      • References
      • Bibliography
    • 9 Particle size analysis
      • Introduction
      • Particle size
      • Particle size analysis methods
      • Selection of a particle size analysis method
      • Reference
      • Bibliography
    • 10 Particle size reduction and size separation
      • Introduction to size reduction
      • Influence of material properties on size reduction
      • Influence of size reduction on size distribution
      • Size reduction methods
      • Selection of the particle size reduction method
      • Introduction to size separation
      • Size separation methods
      • Selection of a size separation process
      • Bibliography
    • 11 Mixing
      • Mixing principles
      • Mechanisms of mixing and demixing
      • Mixing of powders
      • Mixing of miscible liquids and suspensions
      • Mixing of semisolids
      • References
      • Bibliography
    • 12 Powder flow
      • Introduction
      • Particle properties
      • Process conditions: hopper design
      • Characterization of powder flow
      • Improvement of powder flowability
      • Summary
      • Bibliography
  • Part 3 Pharmaceutical microbiology and sterilization
    • 13 Fundamentals of microbiology
      • Introduction
      • Viruses
      • Archaea
      • Eubacteria
      • Fungi
      • Bibliography
    • 14 Pharmaceutical applications of microbiological techniques
      • Introduction
      • Measurement of antimicrobial activity
      • Microbiological quality of pharmaceutical materials
      • References
    • 15 Action of physical and chemical agents on microorganisms
      • Introduction
      • Kinetics of cell inactivation
      • Antimicrobial effects of moist and dry heat
      • Ionizing radiation
      • Ultraviolet radiation
      • Gases
      • Antimicrobial effects of chemical agents
      • References
    • 16 Principles of sterilization
      • Introduction
      • Need for sterility
      • Sterilization parameters
      • Principles of sterilization processes
      • New technologies
      • Summary
      • References
      • Bibliography
    • 17 Sterilization in practice
      • Sterile products
      • Determination of sterilization protocols
      • Recommended pharmacopoeial sterilization processes
      • High-level disinfection
      • Statistical considerations of sterility testing and sterility assurance level
      • Test for sterility of the product
      • Validation of a sterilization process
      • Limitations of sterilization methods
      • Summary
      • References
      • Bibliography
  • Part 4 Biopharmaceutical principles of drug delivery
    • 18 Introduction to biopharmaceutics
      • What is biopharmaceutics?
      • Concept of bioavailability
      • Concept of biopharmaceutics
      • Summary
      • Bibliography
    • 19 Gastrointestinal tract – physiology and drug absorption
      • Introduction
      • Physiological factors influencing oral drug absorption
      • Physiology of the gastrointestinal tract
      • Transit of pharmaceuticals in the gastrointestinal tract
      • Barriers to drug absorption
      • Summary
      • References
      • Bibliography
    • 20 Bioavailability – physicochemical and dosage form factors
      • Introduction
      • Physicochemical factors influencing bioavailability
      • Dosage form factors influencing bioavailability
      • Reference
      • Bibliography
    • 21 Assessment of biopharmaceutical properties
      • Introduction
      • Measurement of key biopharmaceutical properties
      • Assessment of bioavailability
      • Assessment of site of release in vivo
      • Biopharmaceutics classification system
      • Summary
      • References
      • Bibliography
    • 22 Dosage regimens
      • Dosage regimens: influence on the plasma concentration-time profile of a drug in the body
      • One-compartment open model of drug disposition in the body
      • Important factors influencing steady-state plasma concentrations of a drug
      • Summary
      • Bibliography
  • Part 5 Dosage form design and manufacture
    • 23 Pharmaceutical preformulation
      • The concept of preformulation
      • Assay development
      • Solubility
      • Molecular dissociation
      • Partitioning
      • Dissolution rate
      • Salt selection
      • Hygroscopicity
      • Physical form
      • Powder properties
      • Compaction properties
      • Summary
      • References
      • Bibliography
    • 24 Solutions
      • Introduction
      • Pharmaceutical solutions
      • Solution stability
      • Enhancement of drug solubility
      • Bibliography
    • 25 Clarification
      • Introduction
      • Filtration
      • Filtration equipment
      • Centrifugation
      • Bibliography
    • 26 Suspensions
      • Introduction
      • Definition of a suspension
      • Solid particle–liquid vehicle interactions
      • Particle movement in suspensions
      • Dispersibility issues – surface wetting
      • Dissolution issues
      • Ostwald ripening
      • General suspension formulation 1considerations
      • Stability considerations for suspensions
      • Manufacturing considerations
      • Summary
      • Bibliography
    • 27 Emulsions and creams
      • Introduction
      • Emulsions in pharmacy
      • Formulation of emulsions
      • Emulsifying agents (emulsifiers)
      • Creams
      • Manufacture and processing of emulsions and creams
      • Emulsion properties
      • Emulsion stability
      • Stability testing
      • Bibliography
    • 28 Powders, granules and granulation
      • Introduction to powders and granules
      • Powdered and granulated products as dosage forms
      • Granules used as an intermediate in tablet manufacture
      • Pharmaceutical technology of granule production
      • Granulation mechanisms
      • Pharmaceutical granulation equipment and processes
      • Bibliography
    • 29 Drying
      • Introduction
      • Drying of wet solids
      • Types of drying method
      • Convective drying of wet solids
      • Conductive drying of wet solids
      • Radiation drying of wet solids
      • Drying of solutions and suspensions
      • Freeze-drying (lyophilization)
      • Solute migration during drying
      • Bibliography
    • 30 Tablets and compaction
      • Introduction
      • Quality attributes of tablets
      • Tablet manufacturing
      • Tablet excipients
      • Tablet types
      • Tablet testing
      • Fundamental aspects of the compression of powders
      • Fundamental aspects of the compaction of powders
      • Relationships between material properties and tablet strength
      • References
      • Bibliography
    • 31 Modified-release oral drug delivery
      • Modified-release oral drug delivery
      • Designing a modified-release formulation: factors to consider
      • Conclusions
      • References
      • Bibliography
    • 32 Coating of tablets and multiparticulates
      • Introduction
      • Film coating
      • Sugar coating
      • Compression coating
      • Coating of tablets
      • Coating of multiparticulates
      • References
      • Bibliography
    • 33 Hard capsules
      • Introduction
      • Raw materials
      • Manufacture
      • Formulation
      • References
      • Bibliography
    • 34 Soft capsules
      • Introduction
      • Description of the soft gelatin capsule dosage form (softgels)
      • Rationale for the selection of softgels as a dosage form
      • Manufacture of softgels
      • Formulation of softgels
      • Product quality considerations
      • References
    • 35 Dissolution testing of solid dosage forms
      • The relevance of drug dissolution and dissolution testing
      • Dissolution testing
      • Dissolution testing for quality control
      • Predictive dissolution testing
      • Conclusions
      • References
      • Bibliography
    • 36 Parenteral drug delivery
      • Introduction
      • Routes of parenteral administration
      • Pharmacopoeial requirements
      • Absorption from injection sites
      • Excipients
      • Containers
      • Bibliography
    • 37 Pulmonary drug delivery
      • Inhaled drug delivery
      • Formulating and delivering therapeutic inhalation aerosols
      • Methods of aerosol size analysis
      • Reference
      • Bibliography
    • 38 Nasal drug delivery
      • Introduction
      • Anatomy and physiology
      • Drug delivery
      • Nasal delivery systems
      • Summary
      • Bibliography
    • 39 Ocular drug delivery
      • Introduction
      • Anatomy and physiology of the eye
      • Some common ocular conditions and pharmacological interventions
      • Topical ophthalmic preparations
      • Formulating ophthalmic preparations
      • Topical, liquid ophthalmic preparations
      • Barriers to topical ocular drug absorption
      • Increasing drug solubility and absorption in topical ophthalmic preparations
      • Sterility of ophthalmic preparations
      • Ocular drug pharmacokinetics
      • Targeting the posterior segment of the eye
      • Problems with traditional and new ocular drug delivery systems
      • Patient adherence and instillation of eye drops
      • References
      • Bibliography
    • 40 Topical and transdermal drug delivery
      • Introduction
      • Skin structure and function
      • Transport through the skin
      • Experimental methods for studying transdermal drug delivery
      • Transdermal and topical preparations
      • Enhancement of transdermal and topical drug delivery
      • Nail delivery
      • Bibliography
    • 41 Rectal and vaginal drug delivery
      • Introduction
      • Rectal drug delivery
      • Vaginal drug delivery
      • Manufacture of rectal and vaginal dosage forms
      • Quality control of rectal and vaginal dosage forms
      • References
      • Bibliography
    • 42 The formulation and manufacture of plant medicines
      • Introduction
      • Plant-based products in medicinal use
      • Quality control of crude plant drugs
      • Production methods used to obtain plant-derived active constituents
      • Formulation and manufacture of plant-based medicines
      • Summary
      • References
      • Bibliography
    • 43 Delivery of biopharmaceuticals
      • Introduction
      • Protein and peptide drugs
      • Vaccines
      • Nucleic acid drugs
      • Summary
      • References
      • Bibliography
    • 44 Pharmaceutical nanotechnology and nanomedicines
      • Introduction
      • Applications of pharmaceutical nanotechnology
      • Polymer–drug conjugates
      • Antibodies and antibody-drug conjugates
      • Dendrimers
      • Micelle systems
      • Solid nanoparticles
      • Liposomes and bilayer vesicles
      • Microcapsules and microspheres
      • Ongoing developments
      • Bibliography
    • 45 Design and administration of medicines for paediatric and geriatric patients
      • Human development, ageing and drug administration
      • Formulation design for paediatric and geriatric patients
      • Adaptation of existing dosage forms
      • Future developments in the formulation of paediatric and geriatric medicines
      • Summary
      • References
      • Bibliography
  • Part 6 Packaging and stability of pharmaceutical products
    • 46 Packaging
      • Introduction
      • The pharmaceutical pack
      • Packaging materials
      • Packaging and regulatory bodies
      • Repackaging
      • References
      • Bibliography
    • 47 Chemical stability in dosage forms
      • Introduction
      • Chemical degradation reactions
      • Stability of proteins and peptides
      • Bibliography
    • 48 Microbial contamination, spoilage and preservation of medicines
      • The need to protect medicines against microbial spoilage
      • Products and materials vulnerable to spoilage
      • Sources and control of microbial contamination
      • Selection and use of preservatives
      • Preservative interactions with formulation components and containers
      • References
    • 49 Product stability and stability testing
      • Introduction
      • Mechanisms of degradation
      • Stability testing of pharmaceutical products
      • Concluding comments
      • References
      • Bibliography
  • Index

UM RAFBÆKUR Á HEIMKAUP.IS

Bókahillan þín er þitt svæði og þar eru bækurnar þínar geymdar. Þú kemst í bókahilluna þína hvar og hvenær sem er í tölvu eða snjalltæki. Einfalt og þægilegt!

Þú kemst í bækurnar hvar sem er
Þú getur nálgast allar raf(skóla)bækurnar þínar á einu augabragði, hvar og hvenær sem er í bókahillunni þinni. Engin taska, enginn kyndill og ekkert vesen (hvað þá yfirvigt).

Auðvelt að fletta og leita
Þú getur flakkað milli síðna og kafla eins og þér hentar best og farið beint í ákveðna kafla úr efnisyfirlitinu. Í leitinni finnur þú orð, kafla eða síður í einum smelli.

Glósur og yfirstrikanir
Þú getur auðkennt textabrot með mismunandi litum og skrifað glósur að vild í rafbókina. Þú getur jafnvel séð glósur og yfirstrikanir hjá bekkjarsystkinum og kennara ef þeir leyfa það. Allt á einum stað.

Hvað viltu sjá? / Þú ræður hvernig síðan lítur út
Þú lagar síðuna að þínum þörfum. Stækkaðu eða minnkaðu myndir og texta með multi-level zoom til að sjá síðuna eins og þér hentar best í þínu námi.



Fleiri góðir kostir
- Þú getur prentað síður úr bókinni (innan þeirra marka sem útgefandinn setur)
- Möguleiki á tengingu við annað stafrænt og gagnvirkt efni, svo sem myndbönd eða spurningar úr efninu
- Auðvelt að afrita og líma efni/texta fyrir t.d. heimaverkefni eða ritgerðir
- Styður tækni sem hjálpar nemendum með sjón- eða heyrnarskerðingu
Eiginleikar
Vörumerki: Elsevier
Vörunúmer: 9780702070013
Taka af óskalista
Setja á óskalista

Umsagnir

Engar umsagnir
Lesa fleiri umsagnir

Aulton's Pharmaceutics E-Book

Vörumerki: Elsevier
Vörunúmer: 9780702070013
Rafræn bók. Uppl. sendar á netfangið þitt eftir kaup

Veldu vöru

6.990 kr.
Fá vöru senda með tölvupósti
6.990 kr.