Nelson Textbook of Pediatrics, 2-Volume

Höfundar: Robert M. Kliegman, Joseph W. St. Geme III

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Covering every aspect of general pediatric practice , as well as details for many pediatric subspecialists, Nelson Textbook of Pediatrics, 22nd Edition , brings you fully up to date with everything from rapidly changing diagnostic and treatment protocols to new technologies to the wide range of biologic, psychologic, and social problems faced by children today. Edited and written by experts and prominent members of the pediatric medical community, this comprehensive two-volume reference covers both the science and art of pediatric practice.

It remains the reference of choice among pediatricians, pediatric residents, and others involved in the care of young patients, delivering the information you need in a concise, easy-to-use format for everyday reference and study. Features a user-friendly format with short chapters and subchapters that allow you to quickly find the information you need. Includes more than 60 new chapters on topics covering the impact of social factors on children’s health, the impact of genetic discoveries on understanding diagnosing and treating childhood diseases, updating of current evidenced based diagnostic and therapeutic approaches to childhood diseases, and more.

Offers new and expanded information on gene therapy; interferonopathies; reactive infectious mucocutaneous eruption (RIME); e-cigarette or vaping use-associated lung injury (EVALI); monkeypox; food protein-induced enterocolitis syndrome (FPIES); signaling pathway disorders; ciliopathies; very early onset inflammatory bowel disease; Epstein-Barr virus susceptibility disorders; marijuana smoke exposure; and much more.

Features hundreds of new figures and tables throughout for visual clarity and quick reference, real-time videos, and regular updates online , written exclusively for Nelson. Provides fresh perspectives from two new associate editors : Abigail M. Schuh and Cara L. Mack, both of Medical College of Wisconsin. Remains your indispensable source for definitive, evidence-based answers on every aspect of pediatric care.

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Höfundur: Robert M. Kliegman, Joseph W. St. Geme III
Útgáfa:22
Útgáfudagur: 2024-03-29
Engar takmarkanir á útprentun
Engar takmarkanir afritun
Format:ePub
ISBN 13: 9780323883061
Print ISBN: 9780323883054
ISBN 10: 0323883060

Lesa meira Minnka

Efnisyfirlit

Cover image
Title page
Table of Contents
In Memory
Copyright
Dedication
Contributors
Preface
Volume 1
- Part I. The Field of Pediatrics
  - Chapter 1. Overview of Pediatrics
    - Vital Statistics About Children’s Health Globally
    - The Changing Pediatric World
    - The New Normal: Pandemics
    - The New Morbidities
    - Chronic Illness and Children with Special Healthcare Needs
    - Systems of Care
  - Chapter 2. Child Health Disparities
    - Root Historical Causes of Structural Determinants of Health and Health Disparities
    - 2.1. Racism and Child Health
  - Chapter 3. Global Child Health
    - Global Burden and Trends in Child Health
    - The Social Determinants of Child Health and the COVID-19 Pandemic
    - Evidence-Based Interventions and Innovations to Address Child Health Inequities
    - Challenges in Global Health
  - Chapter 4. Quality and Value in Healthcare for Children
    - The Need for Improvement in Quality and Value
    - What are Quality and Value?
    - Frameworks for Quality Improvement
    - Measuring Quality
    - Analyzing Quality Data
    - Expanding Individual Quality Improvement Initiatives to Scale
    - Comparing and Reporting Quality
    - Implications of the U.S. Healthcare Reform for Quality
  - Chapter 5. Safety in Healthcare for Children
    - Error VS Harm
    - Safety Frameworks
    - Identifying and Analyzing Harm, Errors, and Latent Threats
    - Safety Culture
    - Reliability Science, Human Factors Engineering, and High-Reliability Organizations
    - Serious Harm Events and Healthcare-Associated Conditions
    - Safety Opportunities and Gaps
    - Emerging Areas of Safety Research and Improvement
  - Chapter 6. Ethics in Pediatric Care
    - Assent and Parental Permission
    - Treatment of Critically ill Children
    - Neonatal Ethics
    - Declaring Death and Organ Donation
    - Religious or Cultural Objections to Treatment
    - Pediatric Ethics Committees and Ethics Consultation
    - Newborn Screening
    - Genetics, Genomics, and Precision Medicine
    - Adolescent Healthcare
    - Research
    - Justice and Pediatric Ethics
  - Chapter 7. Complementary Therapies and Integrative Medicine
    - Dietary Supplements
    - Dietary Supplement Safety
    - Dietary Supplement Efficacy
    - Massage and Chiropractic
    - Mind-Body Therapies
    - Acupuncture
    - Cannabis
    - Internet Resources
  - Chapter 8. Pediatric Palliative Care
    - Goals of Care and Decision-Making
    - Advance Care Planning
    - Care Settings
    - Communication and Anticipatory Guidance
  - Chapter 9. Domestic and International Adoption
    - Domestic Adoption
    - Intercountry Adoption
    - Role of Pediatricians
  - Chapter 10. Foster and Kinship Care
    - Epidemiology
    - Legislation in the United States
    - Early Childhood Trauma Leads to Poor Health Outcomes
    - Health Issues
    - Healthcare for Children and Adolescents in Foster Care
  - Chapter 11. Medical Evaluation of the Foreign-Born Child
    - Commonly Encountered Infections
    - Immunizations
  - Chapter 12. Cultural Issues in Pediatric Care
    - What is Culture?
    - Culturally Informed Care
  - Chapter 13. Maximizing Children’s Health: Screening, Anticipatory Guidance, and Counseling
    - The Periodicity Schedule and Guidelines
    - Tasks of Well-Child Care
    - Infancy and Early Childhood
    - Middle Childhood and Adolescence
    - Office Intervention for Behavioral and Mental Health Issues
    - Evidence
    - Caring for the Child and Youth in the Context of the Family and Community
  - Chapter 14. Injury Control
    - Scope of the Problem
    - Principles of Injury Control
    - Risk Factors for Childhood Injuries
    - Mechanisms of Injury
    - Psychosocial Consequences of Injuries
  - Chapter 15. Impact of Violence Exposure on Children
    - Impacts of Violence
    - 15.1. Bullying, Cyberbullying, and School Violence
    - 15.2. Media Violence
    - 15.3. Effects of War on Children
  - Chapter 16. Child Trafficking for Sex and Labor
    - Clinical Presentation
    - Approach to the Patient at Risk for Trafficking
    - Examination and Diagnostic Testing
    - Referrals and Resources
  - Chapter 17. Abused and Neglected Children
    - Definitions
    - 17.1. Sexual Abuse
    - 17.2. Factitious Disorder Imposed on Another: Medical Child Abuse (Munchausen Syndrome by Proxy)
  - Chapter 18. Strategies for Health Behavior Change
    - Unified Theory of Behavior Change
    - Transtheoretical Model of Health Behavior Change
    - Common Factors Approach
    - Motivational Interviewing
    - Shared Decision-Making
- Part II. Growth, Development, and Behavior
  - Chapter 19. Developmental and Behavioral Theories
    - BIOPSYCHOSOCIAL MODEL AND ECOBIODEVELOPMENTAL FRAMEWORK: MODELS OF DEVELOPMENT
  - Chapter 20. Positive Parenting and Support
    - THE IMPORTANCE OF PARENTING
    - THE ROLE OF THE FAMILY
    - PARENTING STYLES
    - CHILD TEMPERAMENT
    - CHILD BEHAVIORAL PROBLEMS
    - DEFINING POSITIVE PARENTING
    - PARENTING AS AN INTERVENTION
    - THE ROLE OF THE PEDIATRICIAN
    - DISCIPLINE/PUNISHMENT
  - Chapter 21. Assessment of Fetal Growth and Development
    - SOMATIC DEVELOPMENT
    - NEUROLOGIC DEVELOPMENT
    - BEHAVIORAL DEVELOPMENT
    - PSYCHOLOGIC CHANGES IN PARENTS
    - THREATS TO FETAL DEVELOPMENT
  - Chapter 22. The Newborn
    - PARENTAL ROLE IN PARENT–INFANT ATTACHMENT
    - THE INFANT’S ROLE IN PARENT–INFANT ATTACHMENT
    - IMPLICATIONS FOR THE PEDIATRICIAN
  - Chapter 23. The First Year
    - Age 0-2 Months
    - 23.1. Infant Crying and Colic
  - Chapter 24. The Second Year
    - Age 12–18 Months
    - Age 18–24 Months
  - Chapter 25. The Preschool Years
    - Structural Development of the Brain
    - Physical Development
    - Language, Cognition, and Play
  - Chapter 26. Middle Childhood
    - Physical Development
    - Cognitive Development
    - Social, Emotional, and Moral Development
  - Chapter 27. Assessment of Growth
    - Techniques to Measure Growth
    - Growth Curves
    - Other Growth Considerations
  - Chapter 28. Developmental and Behavioral Surveillance and Screening
    - Developmental and Behavioral Surveillance
    - Developmental and Behavioral Screening
    - Beyond Surveillance and Screening
  - Chapter 29. Child Care
    - Quality, Provision, Regulation, and Access
    - Screening and Support for Child Development and Health
    - Role of Pediatric Providers
  - Chapter 30. Loss, Separation, and Bereavement
    - Separation and Loss
    - Divorce
    - Move/Family Relocation
    - Separation Because of Hospitalization
    - Military Families
    - Parental/Sibling Death
    - Grief and Bereavement
    - Developmental Perspective
    - Role of the Pediatric Healthcare Provider in Grief
    - Treatment
    - Spiritual Issues
  - Chapter 31. Sleep Medicine
    - Basics of Sleep and Chronobiology
    - Developmental Changes in Sleep
    - Common Sleep Disorders
    - Sleep Health Supervision
    - Evaluation of Pediatric Sleep Problems
- Part III. Behavioral and Psychiatric Disorders
  - Chapter 32. Psychosocial Assessment and Psychiatric Diagnostic Evaluation
    - AIMS OF PSYCHOSOCIAL ASSESSMENT IN THE PEDIATRIC SETTING
    - PRESENTING PROBLEMS
    - GENERAL PRINCIPLES OF THE PSYCHOSOCIAL INTERVIEW
    - DIAGNOSIS
    - PSYCHIATRIC DIAGNOSTIC EVALUATION
    - SPECIAL CONSIDERATIONS IN THE DIAGNOSTIC EVALUATION OF INFANTS AND YOUNG CHILDREN
  - Chapter 33. Psychopharmacology
    - Stimulants and Other ADHD Medications
    - Antidepressants
    - Antipsychotics
    - Mood Stabilizers
    - Medication Use in Physical Illness
  - Chapter 34. Psychotherapy
    - Psychotherapy
  - Chapter 35. Somatic Symptom and Related Disorders
    - SOMATIZATION
    - RISK FACTORS FOR SOMATIZATION
    - ASSESSMENT
    - MANAGEMENT
  - Chapter 36. Rumination and Pica
    - 36.1. Rumination Disorder
    - 36.2. Pica
  - Chapter 37. Motor Disorders and Habits
    - 37.1. Tic Disorders
    - 37.2. Stereotypic Movement Disorder
  - Chapter 38. Anxiety Disorders, Obsessive-Compulsive Disorder, and Posttraumatic Stress Disorder
    - ASSESSMENT
    - DIFFERENTIAL DIAGNOSIS AND COMORBIDITIES
    - Treatment of Anxiety
    - Obsessive-Compulsive Disorder and Pediatric Acute-Onset Neuropsychiatric Syndrome
    - SPECIFIC PHOBIAS
  - Chapter 39. Mood Disorders
    - 39.1. Depressive Disorders
    - 39.2. Bipolar Disorders
  - Chapter 40. Suicide and Attempted Suicide
    - Epidemiology
    - Risk Factors
    - Assessment and Intervention
    - Prevention
    - Screening and Early Treatment
    - School Resources
  - Chapter 41. Eating Disorders
    - DEFINITIONS
    - EPIDEMIOLOGY
    - PATHOLOGY AND PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - DIFFERENTIAL DIAGNOSIS
    - LABORATORY FINDINGS
    - COMPLICATIONS
    - TREATMENT
    - PROGNOSIS
    - PREVENTION
  - Chapter 42. Disruptive, Impulse-Control, and Conduct Disorders
    - DESCRIPTION
    - EPIDEMIOLOGY
    - CLINICAL COURSE
    - DIFFERENTIAL DIAGNOSIS
    - COMORBIDITY
    - SEQUELAE
    - ETIOLOGY AND RISK FACTORS
    - PREVENTION
    - SCREENING/CASE FINDING
    - EARLY INTERVENTION
    - TREATMENT
    - LEVEL OF CARE
  - Chapter 43. Tantrums and Breath-Holding Spells
  - Chapter 44. Lying, Stealing, and Truancy
    - STEALING
    - TRUANCY
  - Chapter 45. Aggression
  - Chapter 46. Self-Injurious Behavior
  - Chapter 47. Childhood Psychoses
    - 47.1. Schizophrenia Spectrum Disorders
    - 47.2. Non-Schizophrenia Spectrum Psychotic Disorders
    - 47.3. Catatonia in Children and Adolescents
    - 47.4. Hallucinations of Childhood
  - Chapter 48. Delirium
    - DIAGNOSIS
    - EPIDEMIOLOGY
    - ETIOLOGY
    - ASSESSMENT
    - RATING SCALES
    - MEDICAL EVALUATION
    - DIFFERENTIAL DIAGNOSIS
    - TREATMENT
- Part IV. Learning and Developmental Disorders
  - Chapter 49. Neurodevelopmental and Executive Function and Dysfunction
    - TERMINOLOGY AND EPIDEMIOLOGY
    - ETIOLOGY AND PATHOGENESIS
    - CORE NEURODEVELOPMENTAL FUNCTIONS
    - CLINICAL MANIFESTATIONS
    - ASSESSMENT AND DIAGNOSIS
    - TREATMENT
    - COUNSELING AND PARENT TRAINING PROGRAMS
  - Chapter 50. Attention-Deficit/Hyperactivity Disorder
    - EPIDEMIOLOGY
    - ETIOLOGY
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - TREATMENT
    - PROGNOSIS
    - SECONDARY PREVENTION
  - Chapter 51. Dyslexia
    - DEFINITION
    - EPIDEMIOLOGY
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - IS FAMILY HISTORY HELPFUL IN DIAGNOSING DYSLEXIA?
    - MANAGEMENT
    - Prognosis
  - Chapter 52. Math and Writing Disabilities
    - 52.1. Math Disabilities
    - 52.2. Writing Disabilities
  - Chapter 53. Language Development and Communication Disorders
    - TYPICAL DEVELOPMENT
    - 53.1. Childhood-Onset Fluency Disorder
  - Chapter 54. Augmentative and Alternative Communication
    - DEFINITIONS
  - Chapter 55. Outcomes Among Infants and Children Who Are Deaf/Hard of Hearing
    - DEAF CULTURE
    - EARLY DETECTION AND LANGUAGE DEVELOPMENT
    - INTERVENTIONS
    - LANGUAGE LEARNING
    - ACADEMIC CONSIDERATIONS
    - PSYCHOSOCIAL WELL-BEING
    - DEAF PLUS
    - FAMILY JOURNEY
    - Acknowledgments
  - Chapter 56. Developmental Delay and Intellectual Disability
    - DEFINITION
    - ETIOLOGY
    - EPIDEMIOLOGY
    - PATHOLOGY AND PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - ETIOLOGIC EVALUATION
    - DIFFERENTIAL DIAGNOSIS
    - DIAGNOSTIC PSYCHOLOGIC TESTING
    - COMPLICATIONS AND ASSOCIATED CONDITIONS
    - PREVENTION
    - TREATMENT
    - PRIMARY CARE, SUPPORTIVE CARE, AND MANAGEMENT
    - OUTCOMES
  - Chapter 57. Down Syndrome and Other Abnormalities of Chromosome Number
    - PRINCIPLES OF CARING FOR CHILDREN WITH COMPLEX GENETIC DISORDERS
    - CLINICAL CHARACTERISTICS
    - DEVELOPMENTAL AND BEHAVIORAL CHARACTERISTICS
  - Chapter 58. Autism Spectrum Disorder
    - DEFINITION
    - DIAGNOSTIC CRITERIA AND SYMPTOMS
    - EPIDEMIOLOGY
    - ETIOLOGY
    - DIFFERENTIAL DIAGNOSIS
    - CO-OCCURRING CONDITIONS
    - SCREENING
    - ASSESSMENT
    - TREATMENT AND MANAGEMENT
    - OUTCOME
  - Chapter 59. Fragile X Syndromes
    - EVALUATION AND DIAGNOSIS
    - MANAGEMENT OF FRAGILE X SYNDROME
- Part V. Nutrition
  - Chapter 60. Nutritional Requirements
    - DIETARY REFERENCE INTAKES
    - ENERGY
    - FAT
    - PROTEIN
    - CARBOHYDRATES
    - FIBER
    - MICRONUTRIENTS
    - WATER
    - MEASURING NUTRITIONAL ADEQUACY
  - Chapter 61. Feeding Healthy Infants, Children, and Adolescents
    - FEEDING DURING THE FIRST YEAR OF LIFE
    - COW’S MILK PROTEIN–BASED FORMULAS
    - SOY PROTEIN–BASED FORMULAS
    - PROTEIN HYDROLYSATE FORMULAS
    - AMINO ACID FORMULAS
    - OTHER FLUIDS IN INFANTS AND TODDLERS
    - COMPLEMENTARY FEEDING
    - TRANSITION TO MILK
    - RESPONSIVE FEEDING
    - FEEDING TODDLERS AND PRESCHOOL-AGED CHILDREN
    - FEEDING SCHOOL-AGED CHILDREN AND ADOLESCENTS
    - NUTRITION ISSUES OF IMPORTANCE ACROSS PEDIATRIC AGES
  - Chapter 62. Nutrition, Food Security, and Health
    - MALNUTRITION AS THE INTERSECTION OF FOOD INSECURITY AND HEALTH INSECURITY
    - FOOD SECURITY
    - UNDERNUTRITION
    - SEVERE ACUTE MALNUTRITION
  - Chapter 63. Refeeding Syndrome
  - Chapter 64. Malnutrition in High-Resource Settings
    - CLINICAL MANIFESTATIONS
    - ETIOLOGY AND DIAGNOSIS
    - TREATMENT
    - PROGNOSIS
  - Chapter 65. Overweight and Obesity
    - EPIDEMIOLOGY
    - BODY MASS INDEX
    - ETIOLOGY
    - COMORBIDITIES
    - IDENTIFICATION
    - EVALUATION
    - INTERVENTION
    - PREVENTION
  - Chapter 66. Vitamin A Deficiencies and Excess
    - OVERVIEW OF VITAMIN A
    - METABOLISM OF VITAMIN A
    - FUNCTIONS OF VITAMIN A AND MECHANISMS OF ACTION
    - VITAMIN A DEFICIENCY
    - HYPERVITAMINOSIS A
  - Chapter 67. Vitamin B Complex Deficiencies and Excess
    - 67.1. Thiamine (Vitamin B1)
    - 67.2. Riboflavin (Vitamin B2)
    - 67.3. Niacin (Vitamin B3)
    - 67.4. Vitamin B6 (Pyridoxine)
    - 67.5. Biotin
    - 67.6. Folate
    - 67.7. Vitamin B12 (Cobalamin)
  - Chapter 68. Vitamin C (Ascorbic Acid) Deficiency and Excess
    - DIETARY NEEDS AND SOURCES OF VITAMIN C
    - VITAMIN C DEFICIENCY
    - VITAMIN C TOXICITY
  - Chapter 69. Vitamin D Deficiency (Rickets) and Excess
    - RICKETS
    - VITAMIN D DISORDERS
    - CALCIUM DEFICIENCY
    - PHOSPHORUS DEFICIENCY
    - RICKETS OF PREMATURITY
    - DISTAL RENAL TUBULAR ACIDOSIS
    - HYPERVITAMINOSIS D
  - Chapter 70. Vitamin E Deficiency
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - LABORATORY FINDINGS
    - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
    - TREATMENT
    - PROGNOSIS
    - PREVENTION
  - Chapter 71. Vitamin K Deficiency
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
    - TREATMENT
    - PREVENTION
  - Chapter 72. Micronutrient Mineral Deficiencies
- Part VI. Fluid and Electrolyte Disorders
  - Chapter 73. Electrolyte and Acid-Base Disorders
    - 73.1. Composition of Body Fluids
    - 73.2. Regulation of Osmolality and Volume
    - 73.3. Sodium
    - 73.4. Potassium
    - 73.5. Magnesium
    - 73.6. Phosphorus
    - 73.7. Acid-Base Balance
  - Chapter 74. Maintenance and Replacement Therapy
    - MAINTENANCE THERAPY
    - MAINTENANCE WATER
    - INTRAVENOUS SOLUTIONS
    - GLUCOSE
    - SELECTION OF MAINTENANCE FLUIDS
    - VARIATIONS IN MAINTENANCE WATER AND ELECTROLYTES
    - REPLACEMENT FLUIDS
  - Chapter 75. Deficit Therapy
    - CLINICAL MANIFESTATIONS
    - LABORATORY FINDINGS
    - CALCULATION OF THE FLUID DEFICIT
    - APPROACH TO SEVERE DEHYDRATION
    - MONITORING AND ADJUSTING THERAPY
    - HYPONATREMIC DEHYDRATION
    - HYPERNATREMIC DEHYDRATION
  - Chapter 76. Fluid and Electrolyte Treatment of Specific Disorders
    - ACUTE DIARRHEA
    - PYLORIC STENOSIS
    - PERIOPERATIVE FLUIDS
- Part VII. Emergency Medicine, Critical Care, and Anesthesia
  - Chapter 77. Emergency Medical Services for Children
    - PRIMARY CARE PHYSICIAN AND OFFICE PREPAREDNESS
    - 77.1. Interfacility Transport of the Seriously Ill or Injured Pediatric Patient
    - 77.2. Risk Adjustment and Outcomes Measurement of Pediatric Emergency Medical Services
    - 77.3. Principles Applicable to the Developing World
  - Chapter 78. Triage of the Acutely Ill Child
    - ASSESSMENT OF VITAL SIGNS
    - HISTORY
    - PHYSICAL EXAMINATION
    - MANAGEMENT
    - DISPOSITION
  - Chapter 79. Pediatric Cardiorespiratory Emergencies and Resuscitation
    - ASSESSMENT AND EVALUATION OF CHILDREN WITH CARDIORESPIRATORY EMERGENCIES
    - RECOGNITION AND TREATMENT OF RESPIRATORY DISTRESS AND FAILURE
    - RECOGNITION AND MANAGEMENT OF SHOCK
    - RECOGNITION AND TREATMENT OF ARRHYTHMIAS
    - CARDIAC ARREST AND CARDIOPULMONARY RESUSCITATION
    - PROCEDURES
    - NONVASCULAR EMERGENCY PROCEDURES
  - Chapter 80. Acute Care of Multiple Trauma
    - EPIDEMIOLOGY
    - REGIONALIZATION AND TRAUMA TEAMS
    - ATLS: SYSTEMATIC EVALUATION OF THEINJURED PATIENT
    - PRIMARY SURVEY
    - SECONDARY SURVEY
    - DISPOSITION
    - PSYCHOLOGIC AND SOCIAL SUPPORT
  - Chapter 81. Spinal Cord Injuries in Children
    - CLINICAL MANIFESTATIONS
    - CLEARING THE CERVICAL SPINE IN CHILDREN
    - TREATMENT
    - PREVENTION
  - Chapter 82. Neurologic Emergencies and Stabilization
    - NEUROCRITICAL CARE PRINCIPLES
    - TRAUMATIC BRAIN INJURY
  - Chapter 83. Brain Death: Death by Neurologic Criteria
    - EPIDEMIOLOGY
    - CLINICAL EVALUATION AND DIAGNOSIS
    - OBSERVATION PERIODS
    - ANCILLARY STUDIES
    - DOCUMENTATION
    - AFTER DECLARATION OF BRAIN DEATH
    - OBJECTIONS TO THE CONCEPT OF BRAIN DEATH
  - Chapter 84. Syncope
    - MECHANISMS
    - 84.1. Postural Tachycardia Syndrome
  - Chapter 85. Shock
    - EPIDEMIOLOGY
    - TYPES OF SHOCK
    - PATHOPHYSIOLOGY
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - LABORATORY FINDINGS
    - TREATMENT
    - PROGNOSIS
  - Chapter 86. Acute Care of Respiratory Distress and Failure
    - RESPIRATORY DISTRESS
    - 86.1. Mechanical Ventilation
  - Chapter 87. Altitude-Associated Illness in Children
    - ETIOLOGY
    - ACUTE MOUNTAIN SICKNESS
    - HIGH-ALTITUDE CEREBRAL EDEMA
    - HIGH-ALTITUDE PULMONARY EDEMA
    - SPECIAL CONSIDERATIONS
    - Acknowledgments
  - Chapter 88. Drowning and Submersion Injury
    - ETIOLOGY
    - EPIDEMIOLOGY
    - PATHOPHYSIOLOGY
    - MANAGEMENT
    - PROGNOSIS
    - PREVENTION
  - Chapter 89. Burn Injuries
    - EPIDEMIOLOGY
    - 89.1. Lightning Burns
  - Chapter 90. Cold Injuries
    - MECHANISMS OF HEAT TRANSFER
    - 90.1. Cold-Induced Autoinflammatory and Other Genetic Disorders
  - Chapter 91. Anesthesia and Perioperative Care
    - PREANESTHETIC EVALUATION
    - 91.1. Anesthetic Neurotoxicity
  - Chapter 92. Procedural Sedation
  - Chapter 93. Pediatric Pain Management
    - DEFINITION AND CATEGORIES OF PAIN
    - ASSESSMENT AND MEASUREMENT OF PAIN IN CHILDREN
    - CONCEPTUAL FRAMEWORK FOR TREATMENT OF PEDIATRIC PAIN
    - UNCONVENTIONAL MEDICATIONS IN PEDIATRIC PAIN
    - NONPHARMACOLOGIC TREATMENT OF PAIN
    - INVASIVE INTERVENTIONS FOR TREATING PAIN
    - INTRATHECAL ANALGESIA
    - NERVE ABLATION AND DESTRUCTION
    - CONSIDERATIONS FOR SPECIAL PEDIATRIC POPULATIONS
    - CHRONIC AND RECURRENT PAIN SYNDROMES
    - MANAGING COMPLEX CHRONIC PAIN PROBLEMS
  - Chapter 94. Poisoning
    - PREVENTION
    - APPROACH TO THE POISONED PATIENT
    - PRINCIPLES OF MANAGEMENT
    - SELECT COMPOUNDS IN PEDIATRIC POISONING
- Part VIII. Human Genetics
  - Chapter 95. Genetics in Pediatric Medicine
    - THE BURDEN OF GENETIC DISORDERS IN CHILDHOOD
    - THE CHANGING PARADIGM OF GENETICS IN MEDICINE
    - DIRECT-TO-CONSUMER GENETIC TESTING
    - ETHICS ISSUES
  - Chapter 96. Principles of Human Genetics
    - THE HUMAN GENOME
    - FUNDAMENTALS OF MOLECULAR GENETICS
    - GENETIC VARIATION
    - GENOTYPE-PHENOTYPE CORRELATIONS IN GENETIC DISEASE
    - HUMAN GENOME PROJECT
  - Chapter 97. Patterns of Genetic Transmission
    - FAMILY HISTORY AND PEDIGREE NOTATION
    - MENDELIAN INHERITANCE
    - Y-LINKED INHERITANCE
    - INHERITANCE ASSOCIATED WITH PSEUDOAUTOSOMAL REGIONS
    - DIGENIC INHERITANCE
    - PSEUDOGENETIC INHERITANCE AND FAMILIAL CLUSTERING
    - NONTRADITIONAL INHERITANCE
    - MULTIFACTORIAL AND POLYGENIC INHERITANCE
  - Chapter 98. Integration of Genetics into Pediatric Practice
    - DIAGNOSTIC TESTING
    - PHARMACOGENETICS
    - 98.1. Genetic Counseling
    - 98.2. Principles of Management and Treatment of Genetic Disorders
  - Chapter 99. Chromosome Disorders
    - 99.1. Methods of Chromosome Analysis
    - 99.2. Abnormalities of Chromosome Number
    - 99.3. Abnormalities of Chromosome Structure
    - 99.4. Sex Chromosome Aneuploidy
    - 99.5. Mosaicism
    - 99.6. Chromosome Instability Syndromes
    - 99.7. Uniparental Disomy and Imprinting
  - Chapter 100. Dysmorphology, Phenotyping, and Sequences
    - CLASSIFICATION OF BIRTH DEFECTS
    - MOLECULAR MECHANISMS OF MALFORMATIONS
    - APPROACH TO THE CHILD WITH FACIAL ANOMALIES
  - Chapter 101. Signaling Pathway Disorders
    - 101.1. RAS/MAPK Pathway
    - 101.2. Sonic Hedgehog Pathway
    - 101.3. Ciliopathies
    - 101.4. Craniosynostoses
  - Chapter 102. Chromatin Regulatory Disorders
    - KABUKI SYNDROME
    - RUBINSTEIN-TAYBI SYNDROME
    - CORNELIA DE LANGE SYNDROME
    - COFFIN-SIRIS SYNDROME
    - OTHER CHROMATIN DISORDERS
  - Chapter 103. Genetics of Common Disorders
    - 103.1. Major Genetic Approaches to the Study of Common Pediatric Disorders
- Part IX. Metabolic Disorders
  - Chapter 104. An Approach to Inborn Errors of Metabolism
    - NEWBORN SCREENING
    - CLINICAL MANIFESTATIONS OF GENETIC METABOLIC DISEASES
    - TREATMENT
  - Chapter 105. Defects in Metabolism of Amino Acids
    - 105.1. Phenylalanine
    - 105.2. Tyrosine
    - 105.3. Methionine
    - 105.4. Cysteine and Cystine
    - 105.5. Tryptophan
    - 105.6. Isoleucine, Leucine, Valine, and Related Organic Acidemias
    - 105.7. Glycine
    - 105.8. Serine Deficiency Disorders (Serine Biosynthesis and Transport Defects)
    - 105.9. Proline
    - 105.10. Glutamic Acid
    - 105.11. Disorders of Neurotransmitter Metabolism
    - 105.12. Urea Cycle and Hyperammonemia (Arginine, Citrulline, Ornithine)
    - 105.13. Histidine
    - 105.14. Lysine
    - 105.15. N-Acetylaspartic Acid (Canavan Disease)
  - Chapter 106. Defects in Metabolism of Lipids
    - 106.1. Disorders of Mitochondrial Fatty Acid β-Oxidation
    - 106.2. Disorders of Very Long Chain Fatty Acids and Other Peroxisomal Functions
    - 106.3. Disorders of Lipoprotein Metabolism and Transport
    - 106.4. Lipidoses (Lysosomal Storage Disorders)
    - 106.5. Mucolipidoses
  - Chapter 107. Defects in Metabolism of Carbohydrates
    - 107.1. Glycogen Storage Diseases
    - 107.2. Defects in Galactose Metabolism
    - 107.3. Defects in Fructose Metabolism
    - 107.4. Defects in Intermediary Carbohydrate Metabolism Associated with Lactic Acidosis
    - 107.5. Defects in Pentose Metabolism
    - 107.6. Disorders of Glycoprotein Degradation and Structure
    - 107.7. Congenital Disorders of Glycosylation
  - Chapter 108. Mitochondrial Disease Diagnosis
    - WHEN TO SUSPECT MITOCHONDRIAL DISEASE
    - MITOCHONDRIAL DISEASE INHERITANCE
    - DIAGNOSTIC TESTING FOR MITOCHONDRIAL DISEASE
    - TREATMENT PRINCIPLES FOR MITOCHONDRIAL DISEASE
  - Chapter 109. Mucopolysaccharidoses
    - CLINICAL ENTITIES
    - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
    - TREATMENT
  - Chapter 110. Disorders of Purine and Pyrimidine Metabolism
    - PURINES
    - PYRIMIDINES
    - DISORDERS OF PURINE METABOLISM
    - THE HEREDITARY XANTHINURIAS
    - HPRT1-ASSOCIATED DISORDERS
    - APRT-ASSOCIATED DISORDERS
    - DISORDERS ASSOCIATED WITH AMP-DEAMINASE
    - ADSL-ASSOCIATED DISORDERS
    - OTHER INHERITED PURINE DISORDERS
    - DISORDERS OF PYRIMIDINE METABOLISM
    - DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY
    - DISORDERS ASSOCIATED WITH THYMIDINE KINASE
    - COMBINED DISORDERS OF BOTH PURINES AND PYRIMIDINES
    - DISORDERS ASSOCIATED WITH RIBONUCLEOTIDE REDUCTASE
  - Chapter 111. Hutchinson-Gilford Progeria Syndrome (Progeria)
    - CLINICAL MANIFESTATIONS
    - LABORATORY FINDINGS
    - MOLECULAR PATHOGENESIS
    - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
    - TREATMENT
    - PROGNOSIS
    - PATIENT RESOURCES
  - Chapter 112. The Porphyrias
    - THE HEME BIOSYNTHETIC PATHWAY
    - CLASSIFICATION AND DIAGNOSIS OF PORPHYRIAS
    - δ-AMINOLEVULINIC ACID DEHYDRATASE–DEFICIENT PORPHYRIA
    - ACUTE INTERMITTENT PORPHYRIA
    - CONGENITAL ERYTHROPOIETIC PORPHYRIA
    - PORPHYRIA CUTANEA TARDA
    - HEPATOERYTHROPOIETIC PORPHYRIA
    - HEREDITARY COPROPORPHYRIA
    - VARIEGATE PORPHYRIA
    - ERYTHROPOIETIC PROTOPORPHYRIA AND X-LINKED PROTOPORPHYRIA
    - DUAL PORPHYRIA
    - PORPHYRIA RESULTING FROM TUMORS
  - Chapter 113. Hypoglycemia
    - DEFINITION
    - SIGNIFICANCE AND SEQUELAE
    - PHYSIOLOGIC MECHANISMS OF GLUCOSE HOMEOSTASIS
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - MANAGEMENT
    - DISORDERS OF HYPOGLYCEMIA
    - KETOTIC HYPOGLYCEMIC DISORDERS
    - OTHER CAUSES OF HYPOGLYCEMIA
- Part X. The Fetus and the Neonatal Infant
  - Chapter 114. Overview of Morbidity and Mortality
    - INFANT MORTALITY
    - 114.1. Race, Class, and Birth Outcomes
  - Chapter 115. The Newborn Infant
    - 115.1. Focused Peripartum History
    - 115.2. Physical Examination of the Newborn Infant
    - 115.3. Routine Newborn Care
    - 115.4. Male Circumcision
    - 115.5. Parent–Infant Bonding
  - Chapter 116. High-Risk Pregnancies
    - PRENATAL CARE
    - HIGH-RISK PREGNANCY IDENTIFIED BY ULTRASOUND
    - LABOR AND DELIVERY
  - Chapter 117. The Fetus
    - 117.1. Fetal Growth and Maturity
    - 117.2. Fetal Distress
    - 117.3. Maternal Disease and the Fetus
    - 117.4. Medications and Teratogenic Exposures
    - 117.5. Radiation
    - 117.6. Intrauterine Diagnosis of Fetal Disease
    - 117.7. Treatment and Prevention of Fetal Disease
  - Chapter 118. Fetal Intervention and Surgery
    - FETAL THERAPY ETHICS
    - OBSTRUCTIVE UROPATHY
    - NONOBSTRUCTIVE RENAL DISEASE
    - CONGENITAL DIAPHRAGMATIC HERNIA
    - CONGENITAL PULMONARY AIRWAY MALFORMATION
    - CONGENITAL HIGH AIRWAY OBSTRUCTION SYNDROME
    - SACROCOCCYGEAL TERATOMA
    - MYELOMENINGOCELE
    - TWIN-TO-TWIN TRANSFUSION SYNDROME
    - OTHER INDICATIONS
    - FETAL CENTERS
  - Chapter 119. The High-Risk Infant
    - 119.1. Multiple-Gestation Pregnancies
    - 119.2. Extremely and Very Preterm Infants
    - 119.3. Moderate and Late Preterm Infants
    - 119.4. Term and Postterm Infants
    - 119.5. Follow-Up of High-Risk Infants After Discharge
  - Chapter 120. Transport of the Critically Ill Newborn
    - REGIONALIZED CARE OF NEWBORNS
    - LEVELS OF NEONATAL CARE
    - TRANSPORT OF THE CRITICALLY ILL NEONATE
  - Chapter 121. Clinical Manifestations of Diseases in the Newborn Period
    - ABNORMAL MOVEMENTS
    - 121.1. Hyperthermia
    - 121.2. Hypothermia and Cold Stress
    - 121.3. Edema
    - 121.4. Hypocalcemia
    - 121.5. Hypermagnesemia
  - Chapter 122. Nervous System Disorders
    - 122.1. The Cranium
    - 122.2. Neonatal Traumatic Head Injuries
    - 122.3. Intracranial-Intraventricular Hemorrhage and Periventricular Leukomalacia
    - 122.4. Hypoxic-Ischemic Encephalopathy
    - 122.5. Spine and Spinal Cord
    - 122.6. Peripheral Nerve Injuries
  - Chapter 123. Neonatal Resuscitation and Delivery Room Emergencies
    - NEONATAL RESUSCITATION
    - RESUSCITATION OF THE PRETERM INFANT
    - SPECIAL CIRCUMSTANCES IN THE DELIVERY ROOM
    - INJURY DURING DELIVERY
    - ONGOING CARE AFTER RESUSCITATION
  - Chapter 124. Transition to Newborn Pulmonary Respiration
    - CLEARANCE OF FETAL LUNG FLUID
    - ESTABLISHMENT OF A FUNCTIONAL RESIDUAL CAPACITY
    - INCREASED PULMONARY BLOOD FLOW
    - BREATHING PATTERNS IN NEWBORNS
    - DISORDERED TRANSITION TO PULMONARY RESPIRATION
  - Chapter 125. Apnea
    - OBSTRUCTIVE APNEA
    - CENTRAL APNEA
    - APNEA OF PREMATURITY
    - TREATMENT
    - PROGNOSIS
  - Chapter 126. Respiratory Distress Syndrome (Hyaline Membrane Disease)
    - INCIDENCE
    - 126.1. Patent Ductus Arteriosus
  - Chapter 127. Bronchopulmonary Dysplasia
    - INCIDENCE
    - ETIOLOGY AND PATHOPHYSIOLOGY
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - PREVENTION
    - TREATMENT
    - PROGNOSIS
  - Chapter 128. Transient Tachypnea of the Newborn
    - INCIDENCE
    - ETIOLOGY AND PATHOPHYSIOLOGY
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - PREVENTION
    - TREATMENT
  - Chapter 129. Aspiration of Foreign Material (Meconium Aspiration Syndrome, Aspiration Pneumonia)
    - INTRAPARTUM ASPIRATION
    - POSTPARTUM ASPIRATION
  - Chapter 130. Persistent Pulmonary Hypertension of the Newborn (Persistent Fetal Circulation)
    - PATHOPHYSIOLOGY
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - TREATMENT
    - PROGNOSIS
  - Chapter 131. Diaphragmatic Hernia
    - CONGENITAL DIAPHRAGMATIC HERNIA (BOCHDALEK)
    - 131.1. Foramen of Morgagni Hernia
    - 131.2. Paraesophageal Hernia
    - 131.3. Eventration
  - Chapter 132. Pulmonary Air Leaks: Pneumothorax, Pneumomediastinum, Pulmonary Interstitial Emphysema, Pneumopericardium
    - ETIOLOGY AND PATHOPHYSIOLOGY
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - PREVENTION
    - TREATMENT
  - Chapter 133. Pulmonary Hemorrhage
  - Chapter 134. Digestive System Disorders
  - Chapter 135. Meconium Ileus, Peritonitis, Intestinal Obstruction, and Gastroschisis
    - MECONIUM PLUGS
    - MECONIUM ILEUS
    - MECONIUM PERITONITIS
    - GASTROSCHISIS
  - Chapter 136. Necrotizing Enterocolitis
    - DEFINITION
    - EPIDEMIOLOGY
    - PATHOLOGY AND PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - TREATMENT
    - PROGNOSIS
    - PREVENTION
  - Chapter 137. Jaundice and Hyperbilirubinemia in the Newborn
    - ETIOLOGY
    - 137.1. Kernicterus and Therapy of Hyperbilirubinemia
  - Chapter 138. Blood Disorders
    - NORMAL ERYTHROPOIESIS AND HEMOGLOBIN FUNCTIONS
    - NORMAL RED BLOOD CELL INDICES IN NEONATES AND INFANTS
    - NEUTROPENIA
  - Chapter 139. Anemia in the Newborn Infant
    - THE PHYSIOLOGIC NADIR DURING INFANCY
    - ANEMIA CLASSIFICATIONS AND KEY DIAGNOSTIC MODALITIES
    - HEMOGLOBINOPATHIES
    - ANEMIA MANAGEMENT PRINCIPALS
  - Chapter 140. Hemolytic Disease of the Fetus and Newborn
    - HDFN CAUSED BY Rh INCOMPATIBILITY
    - HDFN CAUSED BY ABO INCOMPATIBILITY
    - OTHER ETIOLOGIES OF HDFN
  - Chapter 141. Neonatal Polycythemia
  - Chapter 142. Hemorrhage in the Newborn Infant
    - HEMORRHAGIC DISEASE OF THE NEWBORN
    - DISSEMINATED INTRAVASCULAR COAGULOPATHY
  - Chapter 143. Nonimmune Hydrops
    - INCIDENCE AND ETIOLOGY
    - PRENATAL DIAGNOSIS AND TREATMENT
    - POSTNATAL DIAGNOSIS AND TREATMENT
    - OUTCOMES
  - Chapter 144. The Umbilicus
    - UMBILICAL HEMORRHAGE
    - UMBILICAL GRANULOMA
    - UMBILICAL INFECTIONS
    - UMBILICAL HERNIA
    - CONGENITAL OMPHALOCELE
    - UMBILICAL TUMORS
  - Chapter 145. Neonatal Abstinence Syndrome
    - TREATMENT AND SETTING
  - Chapter 146. Fetal Alcohol Spectrum Disorder
    - EPIDEMIOLOGY
    - PREVALENCE
    - DIAGNOSTIC SYSTEMS
    - DIAGNOSTIC CRITERIA
    - DIFFERENTIAL DIAGNOSIS
    - OUTCOMES
    - INTERVENTIONS AND TREATMENTS
    - THE PEDIATRICIAN/PRIMARY CARE PROVIDER’S ROLE
  - Chapter 147. Infants of Diabetic Mothers
    - PATHOPHYSIOLOGY
    - CLINICAL MANIFESTATIONS
    - TREATMENT
    - PROGNOSIS
  - Chapter 148. Epidemiology of Infections
    - INCIDENCE
    - MICROBIOLOGY
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - LABORATORY FINDINGS
    - GENERAL APPROACH TO MANAGEMENT
    - PREVENTION
  - Chapter 149. Congenital and Perinatal Infections
    - 149.1. Congenital Infections
    - 149.2. Perinatal Infections
- Part XI. Adolescent Medicine
  - Chapter 150. Adolescent Physical and Social Development
    - PHYSICAL DEVELOPMENT
    - NEUROLOGIC, COGNITIVE, AND MORAL DEVELOPMENT
    - PSYCHOSOCIAL DEVELOPMENT
    - IMPLICATIONS FOR PROVIDERS, PARENTS, AND POLICYMAKERS
  - Chapter 151. Delivery of Healthcare to Adolescents
    - Introduction
    - 151.1. Legal Issues
    - 151.2. Screening Procedures
  - Chapter 152. Transitioning to Adult Care
  - Chapter 153. Gender Identity and Transgender Care
    - TERMINOLOGY
    - EPIDEMIOLOGY
    - MENTAL HEALTH CONSIDERATIONS
    - PUBERTY BLOCKERS
    - GENDER-AFFIRMING SEX HORMONE THERAPY
    - THERAPY FOR NONBINARY YOUTH
  - Chapter 154. Gay, Lesbian, and Bisexual Adolescents
    - PREVALENCE OF HOMOSEXUALITY AND BISEXUALITY IN YOUTH
    - DEVELOPMENT OF SEXUAL ORIENTATION IN CHILDHOOD AND ADOLESCENCE
    - STIGMA, RISK, AND RESILIENCE
    - HEALTH
    - RECOMMENDATIONS FOR CARE
  - Chapter 155. The Epidemiology of Adolescent Health Problems
    - ACCESS TO HEALTHCARE
  - Chapter 156. Violent Behavior
    - EPIDEMIOLOGY
    - ETIOLOGY
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - TREATMENT
    - PREVENTION
  - Chapter 157. Substance Use Disorder
    - ETIOLOGY
    - 157.1. Alcohol
    - 157.2. Tobacco, E-Cigarettes, and Other Tobacco Products
    - 157.3. Marijuana
    - 157.4. Inhalants
    - 157.5. EVALI
    - 157.6. Hallucinogens
    - 157.7. Cocaine
    - 157.8. Amphetamines
    - 157.9. Stimulant Use and Diversion
    - 157.10. Opiates/Opioids
    - 157.11. Synthetic Cannabinoids
  - Chapter 158. The Breast
    - FEMALE DISORDERS
    - MALE DISORDERS
  - Chapter 159. Menstruation-Related Disorders
    - NORMAL MENSTRUATION
    - 159.1. Amenorrhea
    - 159.2. Abnormal Uterine Bleeding
    - 159.3. Dysmenorrhea
    - 159.4. Premenstrual Syndrome and Premenstrual Dysphoric Disorder
  - Chapter 160. Contraception
    - CONTRACEPTIVE EFFECTIVENESS
    - 160.1. Contraceptive Use
    - 160.2. Contraceptive Counseling
    - 160.3. Long-Acting Reversible Contraception
    - 160.4. Other Progestin-Only Methods
    - 160.5. Combined Hormonal Contraceptives
    - 160.6. Emergency Contraception
    - 160.7. Condoms
    - 160.8. Other Barrier Methods
    - 160.9. Other Contraceptive Methods
  - Chapter 161. Adolescent Pregnancy
    - EPIDEMIOLOGY
    - 161.1. Abortion
  - Chapter 162. Adolescent Sexual Assault
    - EPIDEMIOLOGY
    - TERMINOLOGY
    - TYPES OF SEXUAL VIOLENCE
    - CLINICAL MANIFESTATIONS
    - INTERVIEW AND PHYSICAL EXAMINATION
    - LABORATORY DATA
    - TREATMENT
    - FOLLOW-UP
    - PREVENTION
  - Chapter 163. Sexually Transmitted Infections
    - ETIOLOGY
    - EPIDEMIOLOGY
    - PATHOGENESIS
    - SCREENING
    - COMMON INFECTIONS AND CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - TREATMENT
    - PREVENTION
- Immunology
  - Section 1. Evaluation of the Immune System
    - Chapter 164. Orientation to the Consideration of Inborn Errors of Immunity
      - INFECTION RED FLAGS
      - SCHEMA FOR DIAGNOSIS
      - NONINFECTIOUS PRESENTATIONS SUGGESTING PIDD
  - Section 2. The T-, B-, and NK-Cell Systems
    - Chapter 165. T-Cell and Combined Deficiencies
      - T-CELL AND COMBINED DEFICIENCIES
      - 165.1. Severe Combined Immunodeficiencies
      - 165.2. Combined Immunodeficiencies
      - 165.3. Thymic Disorders
      - 165.4. Inborn Errors of Immunity with a Strong Atopic Diathesis
    - Chapter 166. B-Cell and Antibody Deficiencies
      - 166.1. Agammaglobulinemia
      - 166.2. Hypogammaglobulinemia, Transient Hypogammaglobulinemia of Infancy, Specific Antibody Deficiency, and Common Variable Immunodeficiency
      - 166.3. Class Switch Defects
      - 166.4. Isotype Defects
      - 166.5. Transient Hypogammaglobulinemia of Infancy
    - Chapter 167. Natural Killer Cells
      - NK CELL MARKERS, SUBSETS, AND MATURATION
      - NK CELL SPONTANEOUS CYTOTOXICITY
      - NK CELL ANTIBODY-DEPENDENT KILLING
      - FUNCTIONAL NK CELL DEFICIENCY (FNKCD)
      - FUNCTIONAL ASSAYS AVAILABLE FOR CLINICAL EVALUATION
      - NK CELL DEFICIENCY TREATMENT
  - Section 3. The Phagocytic System
    - Chapter 168. Neutrophils
      - THE PHAGOCYTIC INFLAMMATORY RESPONSE
      - HEMATOPOIESIS
      - NEUTROPHIL MATURATION AND KINETICS
      - NEUTROPHIL FUNCTION
    - Chapter 169. Eosinophils
      - DISEASES ASSOCIATED WITH EOSINOPHILIA
    - Chapter 170. Disorders of Phagocyte Function
      - LEUKOCYTE ADHESION DEFICIENCY
      - CHÉDIAK-HIGASHI SYNDROME
      - MYELOPEROXIDASE DEFICIENCY
      - CHRONIC GRANULOMATOUS DISEASE
    - Chapter 171. Leukopenia
      - NEUTROPENIA
      - LYMPHOPENIA
    - Chapter 172. Leukocytosis
      - NEUTROPHILIA
      - ADDITIONAL FORMS OF LEUKOCYTOSIS
  - Section 4. Complement System
    - Chapter 173. Complement System
      - 173.1. Complement Components, Pathways, and Evaluation
      - 173.2. Complement Pathway Deficiencies
  - Section 5. Immune Dysregulation
    - Chapter 174. Immune Dysregulation
      - 174.1. Tregopathies
      - 174.2. Hemophagocytic Lymphohistiocytosis
      - 174.3. Epstein-Barr Virus Susceptibility Disorders
      - 174.4. Chronic Active Epstein-Barr Virus
      - 174.5. Very Early Onset Inflammatory Bowel Disease
      - 174.6. Autoimmune Cytopenias
      - 174.7. Autoimmune Lymphoproliferative Syndrome
      - 174.8. Nuclear Factor-κB Pathway Defects
    - Chapter 175. Defects of Innate Immunity
      - 175.1. Predisposition to Fungal Infections
      - 175.2. Innate Immunity Defects with Predominant Susceptibility to Viral Infections
      - 175.3. Susceptibility to Invasive Bacterial Infections
      - 175.4. Mendelian Susceptibility to Mycobacterial Diseases
    - Chapter 176. Approaches to Treatment of Primary Immune Deficiency Diseases
      - GENERAL INFECTION PREVENTION AND MANAGEMENT STRATEGIES
      - IMMUNIZATIONS
      - GUIDANCE FOR CLOSE CONTACTS
      - COVID-19 VACCINE
      - PROPHYLAXIS
      - IMMUNODEFICIENCIES AFFECTING CELLULAR AND HUMORAL IMMUNITY
      - HYPER-IgM/CD40LG DEFICIENCY
      - COMBINED IMMUNODEFICIENCIES WITH ASSOCIATED OR SYNDROME FEATURES
      - STAT3 HYPER-IgE SYNDROME (JOB SYNDROME)
      - NF-κB ESSENTIAL MODULATOR (NEMO) DEFICIENCY
      - PREDOMINANTLY ANTIBODY DEFICIENCIES
      - CONGENITAL PHAGOCYTE DEFECTS
      - DEFECTS IN INTRINSIC AND INNATE IMMUNITY
      - COMPLEMENT DEFICIENCIES
      - IMMUNOGLOBULIN G REPLACEMENT THERAPY
      - INDICATIONS FOR IgRT
      - NORMAL IMMUNOGLOBULIN LEVELS WITH IMPAIRED SPECIFIC ANTIBODY PRODUCTION
      - INDIVIDUALIZING IgRT
      - CONSIDERATIONS FOR PRODUCT SELECTIONS
      - DOSING CONSIDERATIONS
      - ADMINISTRATION DETAILS
      - VACCINATION WHILE ON IgRT
  - Section 6. Hematopoietic Stem Cell Transplantation
    - Chapter 177. Principles and Clinical Indications of Hematopoietic Stem Cell Transplantation
      - HSCT FROM AN HLA–IDENTICAL SIBLING DONOR
      - ACUTE LYMPHOBLASTIC LEUKEMIA
      - ACUTE MYELOID LEUKEMIA
      - CHRONIC MYELOGENOUS LEUKEMIA
      - JUVENILE MYELOMONOCYTIC LEUKEMIA
      - MYELODYSPLASTIC SYNDROMES OTHER THAN JUVENILE MYELOMONOCYTIC LEUKEMIA
      - NON-HODGKIN LYMPHOMA AND HODGKIN DISEASE
      - ACQUIRED APLASTIC ANEMIA
      - INHERITED BONE MARROW FAILURE SYNDROMES
      - THALASSEMIA
      - SICKLE CELL DISEASE
      - IMMUNODEFICIENCY DISORDERS
      - INHERITED METABOLIC DISEASES
    - Chapter 178. Hematopoietic Stem Cell Transplantation from Alternative Sources and Donors
      - UNRELATED DONOR TRANSPLANTS
      - UMBILICAL CORD BLOOD TRANSPLANTS
      - HAPLOIDENTICAL TRANSPLANTS
      - DONOR VERSUS RECIPIENT NK CELL ALLOREACTIVITY
      - AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION
    - Chapter 179. Graft-Versus-Host Disease, Rejection, and Venoocclusive Disease
      - ACUTE GRAFT-VERSUS-HOST DISEASE
      - CHRONIC GRAFT-VERSUS-HOST DISEASE
      - GRAFT FAILURE
      - VENOOCCLUSIVE DISEASE
    - Chapter 180. Infectious Complications of Hematopoietic Stem Cell Transplantation
    - Chapter 181. Late Effects of Hematopoietic Stem Cell Transplantation
      - ENDOCRINE EFFECTS
      - CARDIOVASCULAR EFFECTS
      - SECONDARY MALIGNANCY
      - GRAFT-VERSUS-HOST DISEASE
      - OTHER EFFECTS
      - SPECIAL CONSIDERATIONS
- Part XIII. Allergic Disorders
  - Chapter 182. Allergy and the Immunologic Basis of Atopic Disease
    - HYGIENE HYPOTHESIS
    - Biodiversity Hypothesis
    - Epithelial Barrier Hypothesis
    - KEY ELEMENTS OF ALLERGIC DISEASES
    - MECHANISMS OF ALLERGIC TISSUE INFLAMMATION
    - GENETIC BASIS OF ATOPY
  - Chapter 183. Diagnosis of Allergic Disease
    - ALLERGY HISTORY
    - PHYSICAL EXAMINATION
    - DIAGNOSTIC TESTING
  - Chapter 184. Allergic Rhinitis
    - ETIOLOGY AND CLASSIFICATION
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - DIFFERENTIAL DIAGNOSIS
    - COMPLICATIONS
    - LABORATORY FINDINGS
    - TREATMENT
    - PROGNOSIS
  - Chapter 185. Childhood Asthma
    - ETIOLOGY
    - EPIDEMIOLOGY
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS AND DIAGNOSIS
    - DIFFERENTIAL DIAGNOSIS
    - LABORATORY FINDINGS
    - TREATMENT
    - PROGNOSIS
    - PREVENTION
  - Chapter 186. Atopic Dermatitis (Atopic Eczema)
    - ETIOLOGY
    - PATHOLOGY
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - LABORATORY FINDINGS
    - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
    - TREATMENT
    - AVOIDING TRIGGERS
    - COMPLICATIONS
    - PROGNOSIS
    - PREVENTION
  - Chapter 187. Insect Allergy
    - ETIOLOGY
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - TREATMENT
    - PREVENTION
  - Chapter 188. Ocular Allergies
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - TREATMENT
  - Chapter 189. Urticaria (Hives) and Angioedema
    - ETIOLOGY AND PATHOGENESIS
    - 189.1. Hereditary Angioedema
  - Chapter 190. Anaphylaxis
    - ETIOLOGY
    - EPIDEMIOLOGY
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - LABORATORY FINDINGS
    - DIAGNOSIS
    - TREATMENT
    - PREVENTION
  - Chapter 191. Serum Sickness
    - ETIOLOGY
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - DIFFERENTIAL DIAGNOSIS
    - DIAGNOSIS
    - TREATMENT
    - PREVENTION
  - Chapter 192. Food Allergy and Adverse Reactions to Foods
    - GENETIC AND ENVIRONMENTAL RISK FACTORS
    - 192.1. Non-IgE Gastrointestinal Food Allergy Disorders
  - Chapter 193. Adverse and Allergic Reactions to Drugs
    - EPIDEMIOLOGY
    - PATHOGENESIS AND CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - TREATMENT
- Part XIV. Rheumatic Diseases of Childhood (Connective Tissue Disease, Collagen Vascular Diseases)
  - Chapter 194. Evaluation of Suspected Rheumatic Disease
    - SYMPTOMS SUGGESTIVE OF RHEUMATIC DISEASE
    - SIGNS SUGGESTIVE OF RHEUMATIC DISEASE
    - LABORATORY TESTING
    - IMAGING STUDIES
  - Chapter 195. Treatment of Rheumatic Diseases
    - PEDIATRIC RHEUMATOLOGY TEAMS AND PRIMARY CARE PHYSICIANS
    - THERAPEUTICS
    - JANUS KINASE INHIBITORS
  - Chapter 196. Juvenile Idiopathic Arthritis
    - EPIDEMIOLOGY
    - ETIOLOGY
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - DIFFERENTIAL DIAGNOSIS
    - LABORATORY FINDINGS
    - TREATMENT
    - PROGNOSIS
  - Chapter 197. Ankylosing Spondylitis and Other Spondyloarthritides
    - EPIDEMIOLOGY
    - ETIOLOGY AND PATHOGENESIS
    - CLINICAL MANIFESTATIONS AND DIAGNOSIS
    - LABORATORY FINDINGS
    - DIFFERENTIAL DIAGNOSIS
    - TREATMENT
    - PROGNOSIS
  - Chapter 198. Reactive and Postinfectious Arthritis
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS AND DIFFERENTIAL DIAGNOSIS
    - DIAGNOSIS
    - TREATMENT
    - COMPLICATIONS AND PROGNOSIS
  - Chapter 199. Systemic Lupus Erythematosus
    - ETIOLOGY
    - 199.1. Neonatal Lupus
  - Chapter 200. Juvenile Dermatomyositis
    - EPIDEMIOLOGY
    - ETIOLOGY
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - DIFFERENTIAL DIAGNOSIS
    - LABORATORY FINDINGS
    - TREATMENT
    - COMPLICATIONS
    - PROGNOSIS
  - Chapter 201. Scleroderma and Raynaud Phenomenon
    - ETIOLOGY AND PATHOGENESIS
    - CLASSIFICATION
    - EPIDEMIOLOGY
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - DIFFERENTIAL DIAGNOSIS
    - TREATMENT
    - PROGNOSIS
  - Chapter 202. Behçet Disease
    - EPIDEMIOLOGY
    - ETIOLOGY AND PATHOGENESIS
    - CLINICAL MANIFESTATIONS AND DIAGNOSIS
    - TREATMENT AND PROGNOSIS
  - Chapter 203. Sjögren Syndrome
    - EPIDEMIOLOGY
    - ETIOLOGY AND PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - DIFFERENTIAL DIAGNOSIS
    - TREATMENT
    - COMPLICATIONS AND PROGNOSIS
  - Chapter 204. Hereditary Periodic Fever Syndromes and Other Systemic Autoinflammatory Diseases
    - CLASSIFICATION OF AUTOINFLAMMATORY DISORDERS
    - AUTOINFLAMMATORY DISEASES WITH PERIODIC OR PROMINENT FEVERS
    - OTHER MENDELIAN AUTOINFLAMMATORY DISEASES
    - GENETICALLY COMPLEX AUTOINFLAMMATORY DISEASES
  - Chapter 205. Interferonopathies
    - AUTOINFLAMMATORY INTERFERONOPATHIES
    - AUTOIMMUNE INTERFERONOPATHIES
  - Chapter 206. Amyloidosis
    - ETIOLOGY
    - EPIDEMIOLOGY
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - LABORATORY FINDINGS
    - TREATMENT
    - PROGNOSIS
    - PREVENTION
  - Chapter 207. Macrophage Activation Syndrome
    - EPIDEMIOLOGY
    - PATHOPHYSIOLOGY AND OTHER HYPERINFLAMMATORY SYNDROMES
    - CLINICAL AND LABORATORY MANIFESTATIONS
    - DIAGNOSIS
    - DIFFERENTIAL DIAGNOSIS
    - TREATMENT
  - Chapter 208. Kawasaki Disease
    - ETIOLOGY
    - EPIDEMIOLOGY
    - PATHOLOGY
    - CLINICAL MANIFESTATIONS
    - LABORATORY AND RADIOLOGY FINDINGS
    - DIAGNOSIS
    - DIFFERENTIAL DIAGNOSIS
    - TREATMENT
    - COMPLICATIONS
    - PROGNOSIS
  - Chapter 209. Sarcoidosis
    - ETIOLOGY
    - EPIDEMIOLOGY
    - PATHOLOGY AND PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - LABORATORY FINDINGS
    - DIAGNOSIS
    - DIFFERENTIAL DIAGNOSIS
    - TREATMENT
    - PROGNOSIS
  - Chapter 210. Vasculitis Syndromes
    - INTRODUCTION
    - 210.1. Henoch-Schönlein Purpura (IgA Vasculitis)
    - 210.2. Takayasu Arteritis
    - 210.3. Polyarteritis Nodosa and Cutaneous Polyarteritis Nodosa
    - 210.4. Antineutrophilic Cytoplasmic Antibody–Associated Vasculitis
    - 210.5. Other Vasculitis Syndromes: Hypersensitivity, CNS, and COVID-19 Related
  - Chapter 211. Musculoskeletal Pain Syndromes
    - CLINICAL MANIFESTATIONS
    - 211.1. Growing Pains (Benign Limb Pain of Childhood)
    - 211.2. Small Fiber Polyneuropathy
    - 211.3. Diffuse Amplified Pain Syndromes
    - 211.4. Complex Regional Pain Syndrome
    - 211.5. Erythromelalgia
  - Chapter 212. Chronic Overlapping Pain Conditions
    - PREVALENCE
    - 212.1. Chronic Fatigue Syndrome
  - Chapter 213. Miscellaneous Conditions Associated with Arthritis
    - RELAPSING POLYCHONDRITIS
    - MUCHA-HABERMANN DISEASE/PITYRIASIS LICHENOIDES ET VARIOLIFORMIS ACUTA
    - SWEET SYNDROME
    - HYPERTROPHIC OSTEOARTHROPATHY
    - PLANT THORN SYNOVITIS
    - PIGMENTED VILLONODULAR SYNOVITIS
- Infectious Diseases
  - Section 1. General Considerations
    - Chapter 214. Public Health Approach to Pandemics
      - INTRODUCTION
      - DEFINITIONS
  - Section 2. Preventive Measures
    - Chapter 215. Immunization Practices
      - PASSIVE IMMUNITY
      - 215.1. International Immunization Practices
    - Chapter 216. Infection Prevention and Control
      - TRANSMISSION IN THE HEALTHCARE SETTING
      - PREVENTION STRATEGIES
      - ENVIRONMENT, DISINFECTION, AND STERILIZATION
      - VISITATION AND PATIENT AND CAREGIVER MANAGEMENT
      - OCCUPATIONAL HEALTH AND CLINICIAN EDUCATION
      - SPECIAL POPULATIONS
    - Chapter 217. Childcare and Communicable Diseases
      - EPIDEMIOLOGY
      - RESPIRATORY TRACT INFECTIONS
      - GASTROINTESTINAL TRACT INFECTIONS
      - SKIN DISEASES
      - INVASIVE ORGANISMS AND SYSTEMIC INFECTIONS
      - HERPESVIRUSES
      - BLOOD-BORNE PATHOGENS
      - ANTIBIOTIC USE AND BACTERIAL RESISTANCE
      - PREVENTION
      - STANDARDS
    - Chapter 218. Health Advice for Children Traveling Internationally
      - THE PEDIATRIC TRAVEL MEDICINE CONSULTATION
      - SAFETY AND PREVENTIVE COUNSELING TOPICS
      - ROUTINE CHILDHOOD VACCINATIONS REQUIRED FOR PEDIATRIC TRAVEL
      - SPECIALIZED PEDIATRIC TRAVEL VACCINATIONS
      - TRAVELER’S DIARRHEA
      - INSECT-BORNE INFECTIONS
      - MALARIA CHEMOPROPHYLAXIS
      - THE RETURNING TRAVELER
      - THE ADOLESCENT TRAVELER
    - Chapter 219. Fever
      - PATHOGENESIS
      - ETIOLOGY
      - CLINICAL FEATURES
      - EVALUATION
      - MANAGEMENT
    - Chapter 220. Fever Without a Focus in the Neonate and Young Infant
      - ETIOLOGY AND EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - LABORATORY DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
    - Chapter 221. Fever in the Older Child
      - DIAGNOSIS
      - GENERAL APPROACH
      - EVALUATION
      - MANAGEMENT
    - Chapter 222. Fever of Unknown Origin
      - ETIOLOGY
      - DIAGNOSIS
      - MANAGEMENT
      - PROGNOSIS
    - Chapter 223. Infections in Immunocompromised Persons
      - 223.1. Infections Occurring with Primary Immunodeficiencies
      - 223.2. Infections Occurring with Acquired Immunodeficiencies
      - 223.3. Prevention of Infection in Immunocompromised Persons
    - Chapter 224. Infection Associated with Medical Devices
      - INTRAVASCULAR ACCESS DEVICES
      - URINARY CATHETERS
      - MECHANICAL VENTILATORS
      - CEREBROSPINAL FLUID SHUNTS
      - PERITONEAL DIALYSIS CATHETERS
      - IMPLANTABLE ORTHOPEDIC DEVICES
  - Section 3. Antibiotic Therapy
    - Chapter 225. Principles of Antibacterial Therapy
      - AGE- AND RISK-SPECIFIC USE OF ANTIBIOTICS IN CHILDREN
      - ANTIBIOTICS, INCLUDING NEWER AGENTS AND THERAPIES COMMONLY USED IN PEDIATRIC PRACTICE
    - Chapter 226. Antimicrobial Stewardship
      - THE NEED FOR ANTIMICROBIAL STEWARDSHIP: HARMS FROM OVERUSE
      - DEFINING ANTIMICROBIAL STEWARDSHIP AND AN ANTIMICROBIAL STEWARDSHIP PROGRAM
      - INPATIENT ANTIMICROBIAL STEWARDSHIP STRATEGIES
      - OUTPATIENT ANTIMICROBIAL STEWARDSHIP STRATEGIES
      - TRACKING AND REPORTING ANTIMICROBIAL USE MEASURES
  - Section 4. Gram-Positive Bacterial Infections
    - Chapter 227. Staphylococcus
      - 227.1. Staphylococcus aureus
      - 227.2. Toxic Shock Syndrome
      - 227.3. Coagulase-Negative Staphylococci
    - Chapter 228. Streptococcus pneumoniae (Pneumococcus)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 229. Group A Streptococcus
      - ETIOLOGY
      - 229.1. Rheumatic Fever
    - Chapter 230. Group B Streptococcus
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - LABORATORY FINDINGS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 231. Non–Group A or B Streptococci
    - Chapter 232. Enterococcus
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - TREATMENT
      - PREVENTION
    - Chapter 233. Diphtheria (Corynebacterium diphtheriae)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - COMPLICATIONS
      - TREATMENT
      - SUPPORTIVE CARE
      - PROGNOSIS
      - PREVENTION
    - Chapter 234. Listeria monocytogenes
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
      - Acknowledgments
    - Chapter 235. Actinomyces
      - TAXONOMY AND MICROBIOLOGY
      - PATHOGENESIS AND EPIDEMIOLOGY
      - DIAGNOSIS
      - COMMON CLINICAL PRESENTATIONS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
    - Chapter 236. Nocardia
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL AND RADIOGRAPHIC MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
  - Section 5. Gram-Negative Bacterial Infections
    - Chapter 237. Neisseria meningitidis (Meningococcus)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS AND PATHOPHYSIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - COMPLICATIONS
      - PROGNOSIS
      - PREVENTION
    - Chapter 238. Neisseria gonorrhoeae (Gonococcus)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS AND PATHOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - COMPLICATIONS
      - PREVENTION
    - Chapter 239. Kingella kingae
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL DISEASE
      - SPONDYLODISCITIS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 240. Haemophilus influenzae
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - DIAGNOSIS
      - CLINICAL MANIFESTATIONS AND TREATMENT
      - PREVENTION
    - Chapter 241. Chancroid (Haemophilus ducreyi)
      - ETIOLOGY AND EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - COMPLICATIONS
    - Chapter 242. Moraxella catarrhalis
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS OF INFECTION
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 243. Pertussis (Bordetella pertussis and Bordetella parapertussis)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - COMPLICATIONS
      - PREVENTION
    - Chapter 244. Salmonella
      - 244.1. Nontyphoidal Salmonellosis
      - 244.2. Enteric Fever (Typhoid and Paratyphoid Fever)
    - Chapter 245. Shigella
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - IMMUNITY
      - CLINICAL MANIFESTATIONS AND COMPLICATIONS
      - DIFFERENTIAL DIAGNOSIS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 246. Escherichia coli
      - ENTEROTOXIGENIC ESCHERICHIA COLI
      - ENTEROINVASIVE ESCHERICHIA COLI
      - ENTEROPATHOGENIC ESCHERICHIA COLI
      - ENTEROAGGREGATIVE ESCHERICHIA COLI
      - SHIGA TOXIN–PRODUCING ESCHERICHIA COLI
      - ENTEROAGGREGATIVE HEMORRHAGIC ESCHERICHIA COLI
      - DIFFUSELY ADHERENT ESCHERICHIA COLI
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION OF ILLNESS
    - Chapter 247. Cholera
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
      - COMPLICATIONS
      - TREATMENT
      - PREVENTION
    - Chapter 248. Campylobacter
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - COMPLICATIONS
      - PROGNOSIS
      - PREVENTION
    - Chapter 249. Yersinia
      - 249.1. Yersinia enterocolitica
      - 249.2. Yersinia pseudotuberculosis
      - 249.3. Plague (Yersinia pestis)
    - Chapter 250. Aeromonas and Plesiomonas
      - 250.1. Aeromonas
      - 250.2. Plesiomonas shigelloides
    - Chapter 251. Pseudomonas, Burkholderia, and Stenotrophomonas
      - 251.1. Pseudomonas aeruginosa
      - 251.2. Burkholderia cepacia Complex
      - 251.3. Stenotrophomonas
    - Chapter 252. Tularemia (Francisella tularensis)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 253. Brucella
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 254. Legionella
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
    - Chapter 255. Bartonella
      - 255.1
      - 255.1. Cat Scratch Disease (Bartonella henselae)
      - 255.2. Bartonellosis (Bartonella bacilliformis)
      - 255.3. Trench Fever (Bartonella quintana)
      - 255.4. Bacillary Angiomatosis and Bacillary Peliosis Hepatis (Bartonella henselae and Bartonella quintana)
  - Section 6. Anaerobic Bacterial Infections
    - Chapter 256. Botulism (Clostridium botulinum)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - SUPPORTIVE CARE
      - COMPLICATIONS
      - PROGNOSIS
      - PREVENTION
    - Chapter 257. Tetanus (Clostridium tetani)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - SUPPORTIVE CARE
      - COMPLICATIONS
      - PROGNOSIS
      - PREVENTION
    - Chapter 258. Clostridioides difficile Infection
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS AND RECURRENCE
      - PREVENTION
    - Chapter 259. Other Anaerobic Infections
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - ANAEROBIC GRAM-NEGATIVE BACILLI
      - ANAEROBIC GRAM-POSITIVE ORGANISMS
  - Section 7. Mycobacterial Infections
    - Chapter 260. Principles of Antimycobacterial Therapy
      - AGENTS USED AGAINST MYCOBACTERIUM TUBERCULOSIS
      - AGENTS USED AGAINST MYCOBACTERIUM LEPRAE
      - AGENTS USED AGAINST NONTUBERCULOUS MYCOBACTERIA
    - Chapter 261. Tuberculosis (Mycobacterium tuberculosis)
      - CLINICAL STAGES
      - EPIDEMIOLOGY
      - TRANSMISSION
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - IMMUNE-BASED TESTING (“TESTS OF TUBERCULOSIS INFECTION”)
      - MYCOBACTERIAL SAMPLING, SUSCEPTIBILITY, AND CULTURE
      - TREATMENT
      - PREVENTION
    - Chapter 262. Hansen Disease (Mycobacterium leprae)
      - MICROBIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - DISEASE CLASSIFICATION
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - LONG-TERM COMPLICATIONS
      - PREVENTION
    - Chapter 263. Nontuberculous Mycobacteria
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
  - Section 8. Spirochetal Infections
    - Chapter 264. Syphilis (Treponema pallidum)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS AND LABORATORY FINDINGS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 265. Nonvenereal Treponemal Infections
      - 265.1. Yaws (Treponema pertenue)
      - 265.2. Bejel (Endemic Syphilis; Treponema pallidum endemicum)
      - 265.3. Pinta (Treponema carateum)
    - Chapter 266. Leptospira
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOLOGY AND PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 267. Relapsing Fever (Borrelia)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOLOGY AND PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 268. Lyme Disease (Borrelia burgdorferi)
      - ETIOLOGY
      - TRANSMISSION
      - EPIDEMIOLOGY
      - PATHOLOGY AND PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
  - Section 9. Mycoplasmal Infections
    - Chapter 269. Mycoplasma pneumoniae
      - THE ORGANISM
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 270. Genital Mycoplasmas (Mycoplasma hominis, Mycoplasma genitalium, and Ureaplasma urealyticum)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - TRANSMISSION
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
  - Section 10. Chlamydial Infections
    - Chapter 271. Chlamydia pneumoniae
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
    - Chapter 272. Chlamydia trachomatis
      - 272.1. Trachoma
      - 272.2. Genital Tract Infections
      - 272.3. Conjunctivitis and Pneumonia in Newborns
      - 272.4. Lymphogranuloma Venereum
    - Chapter 273. Psittacosis (Chlamydia psittaci)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
  - Section 11. Rickettsial Infections
    - Chapter 274. Spotted Fever Group Rickettsioses
      - Introduction
      - 274.1. Rocky Mountain Spotted Fever (Rickettsia rickettsii)
      - 274.2. Mediterranean Spotted Fever or Boutonneuse Fever (Rickettsia conorii)
      - 274.3. Rickettsialpox (Rickettsia akari) and Flea-Borne Spotted Fever
    - Chapter 275. Scrub Typhus (Orientia tsutsugamushi)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - TRANSMISSION
      - PATHOLOGY AND PATHOGENESIS
      - CLINICAL MANIFESTATIONS AND LABORATORY FINDINGS
      - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
      - TREATMENT AND SUPPORTIVE CARE
      - COMPLICATIONS
      - PREVENTION
    - Chapter 276. Typhus Group Rickettsioses
      - 276.1. Murine (Endemic or Flea-Borne) Typhus (Rickettsia typhi)
      - 276.2. Epidemic (Louse-Borne) Typhus (Rickettsia prowazekii)
    - Chapter 277. Ehrlichiosis and Anaplasmosis
      - ETIOLOGY
      - EPIDEMIOLOGY
      - TRANSMISSION
      - PATHOLOGY AND PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - DIAGNOSIS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - COMPLICATIONS AND PROGNOSIS
      - PREVENTION
    - Chapter 278. Q Fever (Coxiella burnetii)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - TRANSMISSION
      - PATHOLOGY AND PATHOGENESIS
      - CLINICAL MANIFESTATIONS AND COMPLICATIONS
      - LABORATORY FINDINGS
      - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - PREVENTION
  - Section 12. Fungal Infections
    - Chapter 279. Principles of Antifungal Therapy
      - POLYENES
      - PYRIMIDINE ANALOGS
      - AZOLES
      - ECHINOCANDINS
    - Chapter 280. Candida
      - 280.1. Neonatal Infections
      - 280.2. Infections in Immunocompetent Children and Adolescents
      - 280.3. Infections in Immunocompromised Children and Adolescents
    - Chapter 281. Cryptococcus neoformans and Cryptococcus gattii
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 282. Malassezia
    - Chapter 283. Aspergillus
      - 283.1. Allergic Disease (Hypersensitivity Syndromes)
      - 283.2. Saprophytic (Noninvasive) Syndromes
      - 283.3. Invasive Disease
    - Chapter 284. Histoplasmosis (Histoplasma capsulatum)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
    - Chapter 285. Blastomycosis
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
    - Chapter 286. Coccidioidomycosis (Coccidioides Species)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 287. Paracoccidioides brasiliensis
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
    - Chapter 288. Sporotrichosis (Sporothrix schenckii)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
    - Chapter 289. Mucormycosis
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
    - Chapter 290. Pneumocystis jirovecii
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - PATHOLOGY
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS AND DIAGNOSIS
      - TREATMENT
      - SUPPORTIVE CARE
      - COMPLICATIONS
      - PROGNOSIS
      - PREVENTION
    - Chapter 291. Other Pathogenic Fungi
      - PHAEOHYPHOMYCOSIS: Cladophialophora bantiana, Bipolaris spp., AND OTHERS
      - HYALOHYPHOMYCOSIS: Fusarium AND Scedosporium spp. AND OTHERS
  - Section 13. Viral Infections
    - Chapter 292. Principles of Antiviral Therapy
      - ANTIVIRALS USED FOR HERPESVIRUSES
      - ANTIVIRALS USED FOR RESPIRATORY VIRAL INFECTIONS
      - ANTIVIRALS USED FOR COVID-19
      - ANTIVIRALS USED FOR HEPATITIS
      - ANTIVIRAL IMMUNE GLOBULINS
    - Chapter 293. Measles
      - ETIOLOGY
      - EPIDEMIOLOGY
      - TRANSMISSION
      - PATHOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - MODIFIED MEASLES INFECTION
      - LABORATORY FINDINGS
      - DIAGNOSIS
      - DIFFERENTIAL DIAGNOSIS
      - COMPLICATIONS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 294. Rubella
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - DIAGNOSES
      - DIFFERENTIAL DIAGNOSES
      - COMPLICATIONS
      - TREATMENT
      - SUPPORTIVE CARE
      - PROGNOSIS
      - PREVENTION
      - VACCINATION
    - Chapter 295. Mumps
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOLOGY AND PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - DIFFERENTIAL DIAGNOSIS
      - COMPLICATIONS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 296. Polioviruses
      - ETIOLOGY
      - EPIDEMIOLOGY
      - TRANSMISSION
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - COMPLICATIONS
      - PROGNOSIS
      - PREVENTION
    - Chapter 297. Nonpolio Enteroviruses
      - ETIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - COMPLICATIONS AND PROGNOSIS
    - Chapter 298. Parvoviruses
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - COMPLICATIONS
      - PREVENTION
    - Chapter 299. Herpes Simplex Virus
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - LABORATORY FINDINGS
      - TREATMENT AND PREVENTION
      - PROGNOSIS
      - PREVENTION
    - Chapter 300. Varicella-Zoster Virus
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - COMPLICATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 301. Epstein-Barr Virus
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - COMPLICATIONS
      - ONCOGENESIS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 302. Cytomegalovirus
      - THE VIRUS AND ITS HOST INTERACTIONS
      - EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 303. Roseola (Human Herpesviruses 6 and 7)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOLOGY AND PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - DIAGNOSIS
      - COMPLICATIONS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 304. Human Herpesvirus 8
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOLOGY AND PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
    - Chapter 305. Influenza Viruses
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - COMPLICATIONS
      - LABORATORY FINDINGS
      - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - SUPPORTIVE CARE
      - PROGNOSIS
      - PREVENTION
    - Chapter 306. Parainfluenza Viruses
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - COMPLICATIONS
      - PROGNOSIS
      - PREVENTION
    - Chapter 307. Respiratory Syncytial Virus
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 308. Human Metapneumovirus
      - ETIOLOGY
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
      - COMPLICATIONS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 309. Adenoviruses
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - COMPLICATIONS
      - TREATMENT
      - PREVENTION
    - Chapter 310. Rhinoviruses
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - COMPLICATIONS
      - TREATMENT
      - PREVENTION
    - Chapter 311. Coronaviruses
      - ETIOLOGY
      - 311.1. COVID-19
    - Chapter 312. Rotaviruses, Caliciviruses, and Astroviruses
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - LABORATORY FINDINGS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 313. Human Papillomaviruses
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - COMPLICATIONS
      - PROGNOSIS
      - PREVENTION
    - Chapter 314. Arboviral Infections
      - ETIOLOGY
      - 314.1. Eastern Equine Encephalitis
      - 314.2. Western Equine Encephalitis
      - 314.3. St. Louis Encephalitis
      - 314.4. West Nile Encephalitis
      - 314.5. Powassan Encephalitis
      - 314.6. La Crosse and California Encephalitis
      - 314.7. Colorado Tick Fever
      - 314.8. Chikungunya Fever
      - 314.9. Venezuelan Equine Encephalitis
      - 314.10. Japanese Encephalitis
      - 314.11. Tick-Borne Encephalitis
      - 314.12. Zika Virus
    - Chapter 315. Dengue Fever, Dengue Hemorrhagic Fever, and Severe Dengue
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - DIFFERENTIAL DIAGNOSIS
      - LABORATORY FINDINGS
      - TREATMENT
      - COMPLICATIONS
      - PROGNOSIS
      - PREVENTION
    - Chapter 316. Yellow Fever
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - COMPLICATIONS
      - PREVENTION
    - Chapter 317. Ebola and Other Viral Hemorrhagic Fevers
      - ETIOLOGY
      - EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 318. Lymphocytic Choriomeningitis Virus
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
      - COMPLICATIONS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 319. Hantavirus Pulmonary Syndrome
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 320. Rabies
      - EPIDEMIOLOGY
      - TRANSMISSION
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIFFERENTIAL DIAGNOSIS
      - DIAGNOSIS
      - TREATMENT AND PROGNOSIS
      - PREVENTION
    - Chapter 321. Polyomaviruses
      - GENOMIC ORGANIZATION
      - PyV EPIDEMIOLOGY
      - BK PyV
      - JC PyV
    - Chapter 322. Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS AND TESTING
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
      - SUMMARY
    - Chapter 323. Human T-Cell Leukemia Viruses (1 and 2)
      - ETIOLOGY
      - EPIDEMIOLOGY AND MODES OF TRANSMISSION
      - DIAGNOSIS
      - CLINICAL MANIFESTATIONS
      - ADULT T-CELL LEUKEMIA/LYMPHOMA
      - HUMAN T-CELL LYMPHOTROPIC VIRUS-1–ASSOCIATED MYELOPATHY
      - HUMAN T-CELL LYMPHOTROPIC VIRUS-2
      - PREVENTION
    - Chapter 324. Transmissible Spongiform Encephalopathies
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS AND PATHOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - LABORATORY FINDINGS
      - TREATMENT
      - GENETIC COUNSELING
      - PROGNOSIS
      - FAMILY SUPPORT
      - PREVENTION
  - Section 14. Antiparasitic Therapy
    - Chapter 325. Principles of Antiparasitic Therapy
      - SELECTED ANTIPARASITIC DRUGS FOR PROTOZOANS
      - SELECTED ANTIPARASITIC DRUGS FOR HELMINTHS AND ECTOPARASITES
  - Section 15. Protozoan Diseases
    - Chapter 326. Primary Amebic Meningoencephalitis
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
    - Chapter 327. Amebiasis
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
      - COMPLICATIONS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 328. Giardiasis and Balantidiasis
      - 328.1. Giardia duodenalis
      - 328.2. Balantidiasis
    - Chapter 329. Cryptosporidium, Cystoisospora, Cyclospora, and Microsporidia
      - CRYPTOSPORIDIUM
      - Diagnosis
      - CYSTOISOSPORA
      - CYCLOSPORA
      - MICROSPORIDIA
    - Chapter 330. Trichomoniasis (Trichomonas vaginalis)
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - COMPLICATIONS
      - TREATMENT
      - PREVENTION
    - Chapter 331. Leishmaniasis (Leishmania)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - DIFFERENTIAL DIAGNOSIS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 332. African Trypanosomiasis (Sleeping Sickness; Trypanosoma brucei Complex)
      - ETIOLOGY
      - LIFE CYCLE
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 333. American Trypanosomiasis (Chagas Disease; Trypanosoma cruzi)
      - ETIOLOGY
      - LIFE CYCLE
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 334. Malaria (Plasmodium)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - TREATMENT OF UNCOMPLICATED MALARIA
      - TREATMENT OF SEVERE MALARIA
      - FOLLOW-UP ORAL ANTIMALARIAL THERAPY FOR SEVERE MALARIA
      - PREVENTION
    - Chapter 335. Babesiosis (Babesia)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 336. Toxoplasmosis (Toxoplasma gondii)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - SYSTEMIC SIGNS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
      - Acknowledgment
  - Section 16. Helminthic Diseases
    - Chapter 337. Ascariasis (Ascaris lumbricoides)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 338. Hookworms (Necator americanus and Ancylostoma spp.)
      - ETIOLOGY
      - 338.1. Cutaneous Larva Migrans
    - Chapter 339. Trichuriasis (Trichuris trichiura)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 340. Enterobiasis (Enterobius vermicularis)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 341. Strongyloidiasis (Strongyloides stercoralis)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 342. Lymphatic Filariasis (Brugia malayi, Brugia timori, and Wuchereria bancrofti)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
    - Chapter 343. Other Tissue Nematodes
      - ONCHOCERCIASIS (ONCHOCERCA VOLVULUS)
      - LOIASIS (LOA LOA)
      - INFECTION WITH ANIMAL FILARIAE
      - ANGIOSTRONGYLUS CANTONENSIS
      - ANGIOSTRONGYLUS COSTARICENSIS
      - DRACUNCULIASIS (DRACUNCULUS MEDINENSIS)
      - GNATHOSTOMA SPINIGERUM
    - Chapter 344. Toxocariasis (Visceral and Ocular Larva Migrans)
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 345. Trichinellosis (Trichinella spiralis)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 346. Schistosomiasis (Schistosoma)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 347. Flukes (Liver, Lung, and Intestinal)
      - LIVER FLUKES
      - LUNG FLUKES
      - INTESTINAL FLUKES
    - Chapter 348. Adult Tapeworm Infections
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - PREVENTION
      - DIPHYLLOBOTHRIASIS (DIBOTHRIOCEPHALUS SPP.)
      - HYMENOLEPIASIS (HYMENOLEPIS)
      - DIPYLIDIASIS (DIPYLIDIUM CANINUM)
    - Chapter 349. Cysticercosis
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PREVENTION
    - Chapter 350. Echinococcosis (Echinococcus granulosus sensu lato and Echinococcus multilocularis)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
Volume 2
- The Digestive System
  - Section 1. Clinical Manifestations of Gastrointestinal Disease
    - Chapter 351. Normal Digestive Tract Phenomena
    - Chapter 352. Major Symptoms and Signs of Digestive Tract Disorders
      - DYSPHAGIA
      - REGURGITATION
      - NAUSEA
      - VOMITING
      - DIARRHEA
      - CONSTIPATION
      - ANOREXIA
      - ABDOMINAL PAIN
      - GASTROINTESTINAL HEMORRHAGE
      - ABDOMINAL DISTENTION AND ABDOMINAL MASSES
      - ACKNOWLEDGMENT
  - Section 2. The Oral Cavity
    - Chapter 353. Development and Developmental Anomalies of the Teeth
      - DEVELOPMENT OF TEETH
    - Chapter 354. Disorders of the Oral Cavity Associated with Other Conditions
    - Chapter 355. Malocclusion
      - VARIATIONS IN GROWTH PATTERNS
      - CROSSBITE
      - OPEN AND CLOSED BITES
      - DENTAL CROWDING
      - DIGIT SUCKING
    - Chapter 356. Cleft Lip and Palate
      - INCIDENCE AND EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS
      - TREATMENT
      - POSTOPERATIVE MANAGEMENT
      - SEQUELAE
      - VELOPHARYNGEAL DYSFUNCTION
    - Chapter 357. Syndromes with Oral Manifestations
    - Chapter 358. Dental Caries
      - ETIOLOGY
      - EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS
      - COMPLICATIONS
      - TREATMENT
      - PREVENTION
    - Chapter 359. Periodontal Diseases
      - GINGIVITIS
      - AGGRESSIVE PERIODONTITIS IN CHILDREN (PREPUBERTAL PERIODONTITIS)
      - AGGRESSIVE PERIODONTITIS IN ADOLESCENTS
      - CYCLOSPORINE- OR PHENYTOIN-INDUCED GINGIVAL OVERGROWTH
      - ACUTE PERICORONITIS
      - NECROTIZING PERIODONTAL DISEASE (ACUTE NECROTIZING ULCERATIVE GINGIVITIS)
    - Chapter 360. Dental Trauma
      - INJURIES TO TEETH
      - INJURIES TO PERIODONTAL STRUCTURES
      - PREVENTION
      - ADDITIONAL CONSIDERATIONS
    - Chapter 361. Common Lesions of the Oral Soft Tissues
      - OROPHARYNGEAL CANDIDIASIS
      - APHTHOUS ULCERS
      - HERPETIC GINGIVOSTOMATITIS
      - RECURRENT HERPES LABIALIS
      - PARULIS
      - CHEILITIS
      - ANKYLOGLOSSIA
      - GEOGRAPHIC TONGUE
      - FISSURED TONGUE
      - DEVELOPMENTAL (NORMAL) VARIATIONS
    - Chapter 362. Diseases of the Salivary Glands and Jaws
      - PAROTITIS
      - RANULA
      - MUCOCELE
      - CONGENITAL LIP PITS
      - ERUPTION CYST
      - XEROSTOMIA
      - SALIVARY GLAND TUMORS
      - HISTIOCYTIC DISORDERS
      - TUMORS OF THE JAW
    - Chapter 363. Diagnostic Radiology in Dental Assessment
  - Section 3. The Esophagus
    - Chapter 364. Embryology, Anatomy, and Function of the Esophagus
      - EMBRYOLOGY
      - 364.1. Common Clinical Manifestations and Diagnostic Aids
    - Chapter 365. Congenital Anomalies
      - 365.1. Esophageal Atresia and Tracheoesophageal Fistula
      - 365.2. Laryngotracheoesophageal Clefts
      - 365.3. Congenital Esophageal Stenosis
    - Chapter 366. Obstructing Disorders of the Esophagus
      - EXTRINSIC
      - INTRINSIC
    - Chapter 367. Dysmotility
      - UPPER ESOPHAGEAL AND UPPER ESOPHAGEAL SPHINCTER DYSMOTILITY (STRIATED MUSCLE)
      - LOWER ESOPHAGEAL AND LOWER ESOPHAGEAL SPHINCTER DYSFUNCTION (SMOOTH MUSCLE)
    - Chapter 368. Hiatal Hernia
    - Chapter 369. Gastroesophageal Reflux Disease
      - PATHOPHYSIOLOGY
      - 369.1. Complications of Gastroesophageal Reflux Disease
    - Chapter 370. Eosinophilic Esophagitis, Pill Esophagitis, and Infective Esophagitis
      - EOSINOPHILIC ESOPHAGITIS
      - INFECTIVE ESOPHAGITIS
      - PILL ESOPHAGITIS
    - Chapter 371. Esophageal Perforation
    - Chapter 372. Esophageal Varices
    - Chapter 373. Ingestions
      - 373.1. Foreign Bodies in the Esophagus
      - 373.2. Caustic Ingestions
  - Section 4. Stomach and Intestines
    - Chapter 374. Normal Development, Structure, and Function of the Stomach and Intestines
      - DEVELOPMENT
      - DIGESTION AND ABSORPTION
      - THE GASTROINTESTINAL MICROBIOTA
    - Chapter 375. Pyloric Stenosis and Other Congenital Anomalies of the Stomach
      - 375.1. Hypertrophic Pyloric Stenosis
      - 375.2. Congenital Gastric Outlet Obstruction
      - 375.3. Gastric Duplication
      - 375.4. Gastric Volvulus
      - 375.5. Hypertrophic Gastropathy
    - Chapter 376. Intestinal Atresia, Stenosis, and Malrotation
      - 376.1. Duodenal Obstruction
      - 376.2. Jejunal and Ileal Atresia and Obstruction
      - 376.3. Malrotation
    - Chapter 377. Intestinal Duplications, Meckel Diverticulum, and Other Remnants of the Omphalomesenteric Duct
      - 377.1. Intestinal Duplication
      - 377.2. Meckel Diverticulum and Other Remnants of the Omphalomesenteric Duct
    - Chapter 378. Motility Disorders and Hirschsprung Disease
      - 378.1. Chronic Intestinal Pseudoobstruction
      - 378.2. Mitochondrial Neurogastrointestinal Encephalomyopathy
      - 378.3. Encopresis and Functional Constipation
      - 378.4. Congenital Aganglionic Megacolon (Hirschsprung Disease)
      - 378.5. Intestinal Neuronal Dysplasia
      - 378.6. Superior Mesenteric Artery Syndrome (Wilkie Syndrome, Cast Syndrome, Arteriomesenteric Duodenal Compression Syndrome)
    - Chapter 379. Ileus, Adhesions, Intussusception, and Closed-Loop Obstructions
      - 379.1. Ileus
      - 379.2. Adhesions
      - 379.3. Intussusception
      - 379.4. Closed-Loop Obstructions
    - Chapter 380. Foreign Bodies and Bezoars
      - 380.1. Foreign Bodies in the Stomach and Intestine
      - 380.2. Bezoars
    - Chapter 381. Peptic Ulcer Disease in Children
      - PATHOGENESIS
      - 381.1. Zollinger-Ellison Syndrome
    - Chapter 382. Inflammatory Bowel Disease
      - 382.1. Chronic Ulcerative Colitis
      - 382.2. Crohn Disease (Regional Enteritis, Regional Ileitis, Granulomatous Colitis)
      - 382.3. Very Early Onset Inflammatory Bowel Disease
    - Chapter 383. Eosinophilic Gastroenteritis
    - Chapter 384. Celiac Disease
      - ETIOLOGY AND EPIDEMIOLOGY
      - GENETICS AND PATHOGENESIS
      - CLINICAL PRESENTATION AND ASSOCIATED DISORDERS
      - DIAGNOSIS
      - TREATMENT
      - THE SPECTRUM OF GLUTEN-RELATED DISORDERS
    - Chapter 385. Disorders of Malabsorption
      - CLINICAL APPROACH
      - 385.1. Evaluation of Children with Suspected Intestinal Malabsorption
      - 385.2. Other Malabsorptive Syndromes
      - 385.3. Intestinal Infections and Infestations Associated with Malabsorption
      - 385.4. Immunodeficiency Disorders
      - 385.5. Immunoproliferative Small Intestinal Disease
      - 385.6. Short Bowel Syndrome
      - 385.7. Chronic Malnutrition
      - 385.8. Enzyme Deficiencies
      - 385.9. Liver and Biliary Disorders Causing Malabsorption
      - 385.10. Rare Inborn Defects Causing Malabsorption
    - Chapter 386. Intestinal Transplantation in Children with Intestinal Failure
      - INDICATIONS FOR INTESTINAL TRANSPLANT
      - TRANSPLANTATION OPERATION
      - POSTOPERATIVE MANAGEMENT
    - Chapter 387. Acute Gastroenteritis in Children
      - BURDEN OF CHILDHOOD DIARRHEA
      - 387.1. Traveler’s Diarrhea
    - Chapter 388. Chronic Diarrhea
      - PATHOPHYSIOLOGY
      - 388.1. Diarrhea from Neuroendocrine Tumors
    - Chapter 389. Disorders of Brain-Gut Interaction (Functional Gastrointestinal Disorders)
      - DISORDERS OF BRAIN-GUT INTERACTION IN INFANTS AND TODDLERS
      - DISORDERS OF BRAIN-GUT INTERACTION IN OLDER CHILDREN AND ADOLESCENTS
      - DEFECATION DISORDERS
    - Chapter 390. Cyclic Vomiting Syndrome
    - Chapter 391. Acute Appendicitis
      - EPIDEMIOLOGY
      - PATHOPHYSIOLOGY
      - APPENDICITIS RISK SCORING SYSTEMS
      - LABORATORY FINDINGS
      - IMAGING STUDIES
      - DIAGNOSIS AND TREATMENT
      - DIFFERENTIAL DIAGNOSIS
      - ANTIBIOTICS
      - SURGICAL INTERVENTION
      - PERFORATED APPENDICITIS
      - NONOPERATIVE MANAGEMENT OF UNCOMPLICATED APPENDICITIS
      - RECURRENT APPENDICITIS
      - INTERVAL APPENDECTOMY
      - INCIDENTAL APPENDICOLITHS
    - Chapter 392. Surgical Conditions of the Anus and Rectum
      - 392.1. Anorectal Malformations
      - 392.2. Anal Fissure
      - 392.3. Perianal Abscess and Fistula
      - 392.4. Hemorrhoids
      - 392.5. Rectal Mucosal Prolapse
    - Chapter 393. Tumors of the Digestive Tract
      - HAMARTOMATOUS TUMORS
      - ADENOMATOUS TUMORS
      - OTHER GASTROINTESTINAL TUMORS
    - Chapter 394. Inguinal Hernias
      - EMBRYOLOGY AND PATHOGENESIS
      - EVALUATION OF ACUTE INGUINAL-SCROTAL SWELLING
      - DIRECT INGUINAL HERNIA
      - FEMORAL HERNIA
      - COMPLICATIONS
  - Section 5. Exocrine Pancreas
    - Chapter 395. Embryology, Anatomy, and Physiology of the Pancreas
      - Introduction
      - 395.1. Pancreatic Anatomic Abnormalities
      - 395.2. Pancreatic Physiology
    - Chapter 396. Pancreatic Function Tests
      - DIRECT TESTS
    - Chapter 397. Disorders of the Exocrine Pancreas
      - DISORDERS ASSOCIATED WITH PANCREATIC INSUFFICIENCY
      - CYSTIC FIBROSIS
      - SHWACHMAN-DIAMOND SYNDROME
      - PEARSON SYNDROME
      - JOHANSON-BLIZZARD SYNDROME
      - ISOLATED ENZYME DEFICIENCIES
      - OTHER SYNDROMES ASSOCIATED WITH PANCREATIC INSUFFICIENCY
    - Chapter 398. Treatment of Pancreatic Insufficiency
    - Chapter 399. Pancreatitis
      - 399.1Acute Pancreatitis
      - 399.2Acute Recurrent and Chronic Pancreatitis
    - Chapter 400. Pancreatic Fluid Collections
      - TREATMENT OF FLUID COLLECTIONS AND NECROSIS
    - Chapter 401. Pancreatic Tumors
  - Section 6. The Liver and Biliary System
    - Chapter 402. Morphogenesis of the Liver and Biliary System
      - HEPATIC ARCHITECTURE
      - METABOLIC FUNCTIONS OF THE LIVER
    - Chapter 403. Manifestations of Liver Disease
      - PATHOLOGIC MANIFESTATIONS
      - 403.1. Evaluation of Patients with Possible Liver Dysfunction
    - Chapter 404. Cholestasis
      - 404.1. Neonatal Cholestasis
      - 404.2. Cholestasis in the Older Child
    - Chapter 405. Metabolic Diseases of the Liver
      - INTRODUCTION
      - 405.1. Inherited Deficient Conjugation of Bilirubin (Familial Nonhemolytic Unconjugated Hyperbilirubinemia)
      - 405.2. Wilson Disease
      - 405.3. Indian Childhood Cirrhosis
      - 405.4. Neonatal Hemochromatosis
      - 405.5. Miscellaneous Metabolic Diseases of the Liver
    - Chapter 406. Viral Hepatitis
      - ISSUES COMMON TO ALL FORMS OF VIRAL HEPATITIS
      - HEPATITIS A
      - HEPATITIS B
      - HEPATITIS C
      - HEPATITIS D
      - HEPATITIS E
      - APPROACH TO ACUTE OR CHRONIC HEPATITIS
    - Chapter 407. Liver Abscess
    - Chapter 408. Liver Disease Associated with Systemic Disorders
      - INFLAMMATORY BOWEL DISEASE
      - 408.1. Nonalcoholic Fatty Liver Disease
    - Chapter 409. Mitochondrial Hepatopathies
      - EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS
      - PRIMARY MITOCHONDRIAL HEPATOPATHIES
      - DIAGNOSTIC EVALUATION
      - TREATMENT OF MITOCHONDRIAL HEPATOPATHIES
    - Chapter 410. Autoimmune Hepatitis
      - ETIOLOGY
      - PATHOLOGY
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
    - Chapter 411. Drug- and Toxin-Induced Liver Injury
      - TREATMENT
      - PROGNOSIS
      - PREVENTION
    - Chapter 412. Acute Hepatic Failure
      - ETIOLOGY
      - PATHOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - TREATMENT
      - PROGNOSIS
    - Chapter 413. Cystic Diseases of the Biliary Tract and Liver
      - CHOLEDOCHAL MALFORMATIONS
      - AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE
      - AUTOSOMAL DOMINANT POLYCYSTIC LIVER DISEASE
    - Chapter 414. Diseases of the Gallbladder
      - ANOMALIES
      - ACUTE HYDROPS
      - CHOLECYSTITIS AND CHOLELITHIASIS
      - BILIARY DYSKINESIA
    - Chapter 415. Portal Hypertension and Varices
      - ETIOLOGY
      - PATHOPHYSIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
    - Chapter 416. Liver Transplantation
      - INDICATIONS
      - TECHNICAL INNOVATIONS
      - IMMUNOSUPPRESSION
      - COMPLICATIONS
      - OUTCOMES
  - Section 7. Peritoneum
    - Chapter 417. Peritoneal Malformations
    - Chapter 418. Ascites
      - 418.1. Chylous Ascites
    - Chapter 419. Peritonitis
      - 419.1. Acute Primary Peritonitis
      - 419.2. Acute Secondary Peritonitis
      - 419.3. Acute Secondary Localized Peritonitis (Peritoneal Abscess)
    - Chapter 420. Epigastric Hernia
      - CLINICAL PRESENTATION
      - 420.1. Incisional Hernia
- The Respiratory System
  - Section 1. Development and Function
    - Chapter 421. Diagnostic Approach to Respiratory Disease
      - HISTORY
      - PHYSICAL EXAMINATION
      - BLOOD GAS ANALYSIS
      - TRANSILLUMINATION OF THE CHEST
      - RADIOGRAPHIC TECHNIQUES
      - PULMONARY FUNCTION TESTING
      - MICROBIOLOGY: EXAMINATION OF LUNG SECRETIONS
      - THE MICROBIOME
      - AIRWAY VISUALIZATION AND LUNG SPECIMEN–BASED DIAGNOSTIC TESTS
    - Chapter 422. Chronic or Recurrent Respiratory Symptoms
      - JUDGING THE SERIOUSNESS OF CHRONIC RESPIRATORY COMPLAINTS
      - 422.1Extrapulmonary Diseases with Pulmonary Manifestations
    - Chapter 423. Sudden Infant Death Syndrome
      - EPIDEMIOLOGY
      - 423.1Sudden Unexpected Postnatal Collapse/Sudden Unexpected Early Neonatal Death
    - Chapter 424. Brief Resolved Unexplained Events and Other Acute Events in Infants
      - DEFINITION
      - EPIDEMIOLOGY
      - INITIAL HISTORY
  - Section 2. Disorders of the Respiratory Tract
    - Chapter 425. Congenital Disorders of the Nose
      - NORMAL NEWBORN NOSE
      - PHYSIOLOGY
      - CONGENITAL DISORDERS
      - CHOANAL ATRESIA
      - CONGENITAL DEFECTS OF THE NASAL SEPTUM
      - PYRIFORM APERTURE STENOSIS
      - CONGENITAL MIDLINE NASAL MASSES
      - DIAGNOSIS AND TREATMENT
    - Chapter 426. Acquired Disorders of the Nose
      - 426.1. Nasal Foreign Bodies
      - 426.2. Epistaxis
    - Chapter 427. Nasal Polyps
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
      - TREATMENT
    - Chapter 428. The Common Cold
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - LABORATORY FINDINGS
      - TREATMENT
      - COMPLICATIONS
      - PREVENTION
    - Chapter 429. Sinusitis
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - COMPLICATIONS
      - PREVENTION
    - Chapter 430. Acute Pharyngitis
      - INFECTIOUS ETIOLOGIES
      - DIAGNOSIS
      - TREATMENT
      - CHRONIC GROUP A STREPTOCOCCUS CARRIERS
      - RECURRENT PHARYNGITIS
      - COMPLICATIONS AND PROGNOSIS
      - PREVENTION
    - Chapter 431. Tonsils and Adenoids
      - NORMAL FUNCTION
      - PATHOLOGY
      - CLINICAL MANIFESTATIONS
      - TREATMENT
      - COMPLICATIONS
      - CHRONIC AIRWAY OBSTRUCTION
    - Chapter 432. Retropharyngeal Abscess, Lateral Pharyngeal (Parapharyngeal) Abscess, and Peritonsillar Cellulitis/Abscess
      - RETROPHARYNGEAL AND LATERAL PHARYNGEAL ABSCESS
      - PERITONSILLAR CELLULITIS AND/OR ABSCESS
    - Chapter 433. Acute Inflammatory Upper Airway Obstruction (Croup, Epiglottitis, Laryngitis, and Bacterial Tracheitis)
      - 433.1. Infectious Upper Airway Obstruction
      - 433.2. Bacterial Tracheitis
    - Chapter 434. Congenital Anomalies of the Larynx, Trachea, and Bronchi
      - Introduction
      - 434.1. Laryngomalacia
      - 434.2. Congenital Subglottic Stenosis
      - 434.3. Vocal Cord Paralysis
      - 434.4. Congenital Laryngeal Webs and Atresia
      - 434.5. Congenital Subglottic Hemangioma
      - 434.6. Laryngoceles and Saccular Cysts
      - 434.7. Posterior Laryngeal Cleft and Laryngotracheoesophageal Cleft
      - 434.8. Vascular and Cardiac Anomalies
      - 434.9. Tracheal Stenoses, Webs, and Atresia
      - 434.10. Foregut Cysts
      - 434.11. Tracheomalacia and Bronchomalacia
    - Chapter 435. Foreign Bodies in the Airway
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - 435.1. Laryngeal Foreign Bodies
      - 435.2. Tracheal Foreign Bodies
      - 435.3. Bronchial Foreign Bodies
    - Chapter 436. Laryngotracheal Stenosis and Subglottic Stenosis
      - 436.1. Congenital Subglottic Stenosis
      - 436.2. Acquired Laryngotracheal Stenosis
    - Chapter 437. Bronchomalacia and Tracheomalacia
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
    - Chapter 438. Neoplasms of the Larynx, Trachea, and Bronchi
      - 438.1. Vocal Nodules
      - 438.2. Recurrent Respiratory Papillomatosis
      - 438.3. Congenital Subglottic Hemangioma
      - 438.4. Vascular Malformations
      - 438.5. Other Laryngeal Neoplasms
      - 438.6. Tracheal Neoplasms
      - 438.7. Bronchial Tumors
    - Chapter 439. Wheezing, Bronchiolitis, and Bronchitis
      - 439.1. Wheezing in Infants: Bronchiolitis
      - 439.2. Bronchitis
    - Chapter 440. Plastic Bronchitis
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - COMPLICATIONS AND PROGNOSIS
    - Chapter 441. Emphysema and Overinflation
      - LOCALIZED OBSTRUCTIVE OVERINFLATION
      - GENERALIZED OBSTRUCTIVE OVERINFLATION
    - Chapter 442. α1-Antitrypsin Deficiency and Emphysema
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - TREATMENT
      - SUPPORTIVE THERAPY
    - Chapter 443. Other Distal Airway Diseases
      - 443.1. Bronchiolitis Obliterans
      - 443.2. Follicular Bronchitis
      - 443.3. Pulmonary Alveolar Microlithiasis
    - Chapter 444. Congenital Disorders of the Lung
      - 444.1. Pulmonary Agenesis and Aplasia
      - 444.2. Pulmonary Hypoplasia
      - 444.3. Congenital Pulmonary Airway Malformation (Congenital Cystic Adenomatoid Malformation)
      - 444.4. Pulmonary Sequestration
      - 444.5. Bronchogenic Cysts
      - 444.6. Congenital Pulmonary Lymphangiectasia
      - 444.7. Lung Hernia
      - 444.8. Other Congenital Malformations of the Lung
    - Chapter 445. Pulmonary Edema
      - PATHOPHYSIOLOGY
      - ETIOLOGY
      - CLINICAL MANIFESTATIONS
      - TREATMENT
    - Chapter 446. Acute Aspiration
      - ASPIRATION SYNDROMES
      - GASTRIC CONTENTS
      - HYDROCARBON ASPIRATION
      - ASPIRATION OF OTHER SUBSTANCES
      - PRINCIPLES OF MANAGEMENT
      - PREVENTION
      - PROGNOSIS
    - Chapter 447. Chronic Recurrent Aspiration
      - CLINICAL PRESENTATION
      - DIAGNOSIS
      - MANAGEMENT
    - Chapter 448. Immune and Inflammatory Lung Disease
      - 448.1. Hypersensitivity Pneumonia
      - 448.2. Occupational and Environmental Lung Disease
      - 448.3. Granulomatous Lung Disease
      - 448.4. Eosinophilic Lung Disease
      - 448.5. Interstitial Lung Disease
      - 448.6. Neuroendocrine Cell Hyperplasia of Infancy
      - 448.7. Fibrotic Lung Disease
    - Chapter 449. Community-Acquired Pneumonia
      - ETIOLOGY
      - 449.1. COVID-19
    - Chapter 450. E-Cigarette or Vaping Product Use–Associated Lung Injury (EVALI)
      - EPIDEMIOLOGY
      - PATHOPHYSIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
    - Chapter 451. Pleurisy, Pleural Effusions, and Empyema
      - 451.1. Dry Pleurisy
      - 451.2. Serofibrinous or Serosanguineous Pleurisy with Pleural Effusion
      - 451.3. Empyema
    - Chapter 452. Bronchiectasis
      - PATHOPHYSIOLOGY AND PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
    - Chapter 453. Pulmonary Abscess
      - PATHOLOGY AND PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
    - Chapter 454. Cystic Fibrosis
      - GENETICS
      - PATHOGENESIS
      - PATHOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS AND ASSESSMENT
      - DIAGNOSIS OF CF VIA NEWBORN SCREENING
      - DIAGNOSIS OF CYSTIC FIBROSIS OUTSIDE OF NEWBORN SCREENING
      - OTHER LABORATORY TESTING OF IMPORTANCE IN DIAGNOSIS AND MANAGEMENT
      - MANIFESTATIONS OF REDUCED CFTR FUNCTION THAT DO NOT MEET CRITERIA FOR CF
      - TREATMENT
      - TREATMENT OF PULMONARY COMPLICATIONS
      - TREATMENT OF INTESTINAL COMPLICATIONS
      - OTHER COMPLICATIONS
      - PROGNOSIS
    - Chapter 455. Primary Ciliary Dyskinesia (Immotile Cilia Syndrome, Kartagener Syndrome)
      - NORMAL CILIARY ULTRASTRUCTURE AND FUNCTION
      - GENETICS OF PRIMARY CILIARY DYSKINESIA
      - CLINICAL MANIFESTATIONS OF PRIMARY CILIARY DYSKINESIA
      - DIAGNOSIS OF PRIMARY CILIARY DYSKINESIA
      - TREATMENT
      - PROGNOSIS
    - Chapter 456. Diffuse Lung Diseases in Childhood
      - 456.1. Inherited Disorders of Surfactant Metabolism
      - 456.2. Pulmonary Alveolar Proteinosis
    - Chapter 457. Pulmonary Hemosiderosis
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOLOGY
      - PATHOPHYSIOLOGY
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS AND DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
    - Chapter 458. Pulmonary Embolism, Infarction, and Hemorrhage
      - 458.1. Pulmonary Embolus and Infarction
      - 458.2. Pulmonary Hemorrhage and Hemoptysis
    - Chapter 459. Atelectasis
      - PATHOPHYSIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
    - Chapter 460. Pulmonary Tumors
      - CLINICAL MANIFESTATIONS AND EVALUATION
    - Chapter 461. Pneumothorax
      - ETIOLOGY AND EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
      - TREATMENT
    - Chapter 462. Pneumomediastinum
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - TREATMENT
      - COMPLICATIONS
    - Chapter 463. Hydrothorax
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - TREATMENT
    - Chapter 464. Hemothorax
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
    - Chapter 465. Chylothorax
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS AND IMAGING
      - TREATMENT
      - COMPLICATIONS
    - Chapter 466. Bronchopulmonary Dysplasia
      - CLINICAL MANIFESTATIONS
      - TREATMENT
      - PROGNOSIS
    - Chapter 467. Skeletal Diseases Influencing Pulmonary Function
      - 467.1. Pectus Excavatum (Funnel Chest)
      - 467.2. Pectus Carinatum and Sternal Clefts
      - 467.3. Asphyxiating Thoracic Dystrophy (Thoracic-Pelvic-Phalangeal Dystrophy)
      - 467.4. Achondroplasia
      - 467.5. Kyphoscoliosis: Adolescent Idiopathic Scoliosis and Congenital Scoliosis
      - 467.6. Congenital Rib Anomalies
    - Chapter 468. Chronic Respiratory Insufficiency
      - 468.1. Chronic Respiratory Failure and Long-Term Mechanical Ventilation
      - 468.2. Congenital Central Hypoventilation Syndrome
      - 468.3. Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation
      - 468.4. Long-Term Ventilation and Technology Support: Indications, Principles, Decision-Making, Pragmatics, and Home Provision
- The Cardiovascular System
  - Section 1. Developmental Biology of the Cardiovascular System
    - Chapter 469. Cardiac Development
      - INTRODUCTION
      - 469.1. Early Cardiac Morphogenesis
      - 469.2. Cardiac Looping
      - 469.3. Cardiac Septation
      - 469.4. Aortic Arch Development
      - 469.5. Cardiac Differentiation
      - 469.6. Developmental Changes in Cardiac Function
    - Chapter 470. The Fetal to Neonatal Circulatory Transition
      - 470.1. The Fetal Circulation
      - 470.2. The Transitional Circulation
      - 470.3. The Neonatal Circulation
      - 470.4. Persistent Pulmonary Hypertension of the Neonate (Persistence of Fetal Circulatory Pathways)
  - Section 2. Evaluation of the Cardiovascular System and the Child With a Heart Murmur
    - Chapter 471. History and Physical Examination in Cardiac Evaluation
      - HISTORY
      - GENERAL PHYSICAL EXAMINATION
      - CARDIAC EXAMINATION
    - Chapter 472. Laboratory Cardiac Evaluation
      - 472.1. Radiologic Cardiac Assessment
      - 472.2. Electrocardiography
      - 472.3. Hematologic Data in Cardiovascular Evaluation
      - 472.4. Echocardiography
      - 472.5. Exercise Testing
      - 472.6. Cardiac Imaging Studies
      - 472.7. Diagnostic and Interventional Cardiac Catheterization
  - Section 3. Congenital Heart Disease
    - Chapter 473. Epidemiology and Genetic Basis of Congenital Heart Disease
      - ETIOLOGY
      - GENETIC COUNSELING
    - Chapter 474. Evaluation and Screening of the Infant or Child with Congenital Heart Disease
      - ACYANOTIC CONGENITAL HEART LESIONS
      - CYANOTIC CONGENITAL HEART LESIONS
    - Chapter 475. Acyanotic Congenital Heart Disease: Left-to-Right Shunt Lesions
      - 475.1. Atrial Septal Defect
      - 475.2. Ostium Secundum Defect
      - 475.3. Sinus Venosus Atrial Septal Defect
      - 475.4. Partial Anomalous Pulmonary Venous Return
      - 475.5. Atrioventricular Septal Defects (Ostium Primum and Atrioventricular Canal or Endocardial Cushion Defects)
      - 475.6. Ventricular Septal Defect
      - 475.7. Supracristal Ventricular Septal Defect with Aortic Insufficiency
      - 475.8. Patent Ductus Arteriosus
      - 475.9. Aortopulmonary Window Defect
      - 475.10. Coronary Artery Fistula
      - 475.11. Ruptured Sinus of Valsalva Aneurysm
    - Chapter 476. Acyanotic Congenital Heart Disease: Obstructive Lesions
      - 476.1. Pulmonary Valve Stenosis with Intact Ventricular Septum
      - 476.2. Infundibular Pulmonary Stenosis and Double-Chamber Right Ventricle
      - 476.3. Pulmonary Stenosis in Combination with an Intracardiac Shunt
      - 476.4. Peripheral Pulmonary Stenosis
      - 476.5. Aortic Stenosis
      - 476.6. Coarctation of the Aorta
      - 476.7. Coarctation with Ventricular Septal Defect
      - 476.8. Coarctation with Other Cardiac Anomalies and Interrupted Aortic Arch
      - 476.9. Congenital Mitral Stenosis
      - 476.10. Pulmonary Venous Hypertension
    - Chapter 477. Acyanotic Congenital Heart Disease: Regurgitant Lesions
      - 477.1. Pulmonary Valvular Insufficiency and Congenital Absence of the Pulmonary Valve
      - 477.2. Congenital Mitral Insufficiency
      - 477.3. Mitral Valve Prolapse
      - 477.4. Tricuspid Regurgitation
    - Chapter 478. Cyanotic Congenital Heart Disease: Evaluation of the Critically Ill Neonate with Cyanosis and Respiratory Distress
      - CARDIAC DISEASE LEADING TO CYANOSIS
      - DIFFERENTIAL DIAGNOSIS
    - Chapter 479. Cyanotic Congenital Heart Disease: Lesions Associated with Decreased Pulmonary Blood Flow
      - 479.1. Tetralogy of Fallot
      - 479.2. Tetralogy of Fallot with Pulmonary Atresia
      - 479.3. Pulmonary Atresia with Intact Ventricular Septum
      - 479.4. Tricuspid Atresia
      - 479.5. Double-Outlet Right Ventricle
      - 479.6. Transposition of the Great Arteries with Ventricular Septal Defect and Pulmonary Stenosis
      - 479.7. Ebstein Anomaly of the Tricuspid Valve
    - Chapter 480. Cyanotic Congenital Heart Disease: Lesions Associated with Increased Pulmonary Blood Flow
      - 480.1. d-Transposition of the Great Arteries
      - 480.2. d-Transposition of the Great Arteries with Intact Ventricular Septum
      - 480.3. Transposition of the Great Arteries with Ventricular Septal Defect
      - 480.4. l-Transposition of the Great Arteries (Corrected Transposition)
      - 480.5. Double-Outlet Right Ventricle Without Pulmonary Stenosis
      - 480.6. Double-Outlet Right Ventricle with Malposition of the Great Arteries (Taussig-Bing Anomaly)
      - 480.7. Total Anomalous Pulmonary Venous Return
      - 480.8. Truncus Arteriosus
      - 480.9. Single Ventricle (Double-Inlet Ventricle, Univentricular Heart)
      - 480.10. Hypoplastic Left Heart Syndrome
      - 480.11. Abnormal Positions of the Heart and the Heterotaxy Syndromes (Asplenia, Polysplenia)
    - Chapter 481. Other Congenital Heart and Vascular Malformations
      - 481.1. Anomalies of the Aortic Arch
      - 481.2. Anomalous Origin of the Coronary Arteries
      - 481.3. Pulmonary Arteriovenous Fistula
      - 481.4. Ectopia Cordis
      - 481.5. Diverticulum of the Left Ventricle
    - Chapter 482. Pulmonary Hypertension
      - 482.1. Primary Pulmonary Hypertension
      - 482.2. Pulmonary Vascular Disease (Eisenmenger Syndrome)
    - Chapter 483. General Principles of Treatment of Congenital Heart Disease
      - POSTOPERATIVE MANAGEMENT
      - 483.1. Congenital Heart Disease in Adults
  - Section 4. Cardiac Arrhythmias
    - Chapter 484. Disturbances of Rate and Rhythm of the Heart
      - 484.1. Principles of Antiarrhythmic Therapy
      - 484.2. Sinus Arrhythmias and Extrasystoles
      - 484.3. Supraventricular Tachycardia
      - 484.4. Ventricular Tachyarrhythmias
      - 484.5. Long QT Syndromes
      - 484.6. Sinus Node Dysfunction
      - 484.7. Atrioventricular Block
    - Chapter 485. Sudden Death
      - MECHANISM OF SUDDEN DEATH
      - CONGENITAL HEART DISEASE
      - CARDIOMYOPATHY
      - CARDIAC ARRHYTHMIA
      - MISCELLANEOUS CAUSES
      - EVALUATION AND THERAPY FOR RESUSCITATED PATIENTS
      - MEDICATION FOR ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
      - PREVENTION OF SUDDEN DEATH
  - Section 5. Acquired Heart Disease
    - Chapter 486. Infective Endocarditis
      - ETIOLOGY
      - EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - PROGNOSIS AND COMPLICATIONS
      - TREATMENT
      - PREVENTION
    - Chapter 487. Rheumatic Heart Disease
      - PATTERNS OF VALVULAR DISEASE
  - Section 6. Diseases of the Myocardium and Pericardium
    - Chapter 488. Diseases of the Myocardium
      - 488.1. Dilated Cardiomyopathy
      - 488.2. Hypertrophic Cardiomyopathy
      - 488.3. Restrictive Cardiomyopathy
      - 488.4. Left Ventricular Noncompaction, Arrhythmogenic Right Ventricular Cardiomyopathy, Endocardial Fibroelastosis, and Takotsubo Cardiomyopathy
      - 488.5. Myocarditis
    - Chapter 489. Diseases of the Pericardium
      - 489.1. Acute Pericarditis
      - 489.2. Constrictive Pericarditis
    - Chapter 490. Tumors of the Heart
  - Section 7. Cardiac Therapeutics
    - Chapter 491. Heart Failure
      - PATHOPHYSIOLOGY
      - ETIOLOGY OF HEART FAILURE
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT
      - ELECTROPHYSIOLOGIC APPROACHES TO HEART FAILURE MANAGEMENT
      - 491.1. Cardiogenic Shock
    - Chapter 492. Pediatric Heart and Heart-Lung Transplantation
      - 492.1. Pediatric Heart Transplantation
      - 492.2. Heart-Lung and Lung Transplantation
  - Section 8. Diseases of the Peripheral Vascular System
    - Chapter 493. Diseases of the Blood Vessels (Aneurysms and Fistulas)
      - 493.1. Aneurysms
      - 493.2. Arteriovenous Fistulas
      - 493.3. Generalized Arterial Calcification of Infancy (Idiopathic Infantile Arterial Calcification)
      - 493.4. Arterial Tortuosity
    - Chapter 494. Systemic Hypertension
      - PREVALENCE OF HYPERTENSION IN CHILDREN
      - DEFINITION OF HYPERTENSION
      - BLOOD PRESSURE MEASUREMENT IN CHILDREN
      - ETIOLOGY AND PATHOPHYSIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - PREVENTION
      - TREATMENT
- Diseases of the Blood
  - Section 1. The Hematopoietic System
    - Chapter 495. Development of the Hematopoietic System
      - HEMATOPOIESIS IN THE HUMAN EMBRYO AND FETUS
      - FETAL GRANULOCYTOPOIESIS
      - FETAL THROMBOPOIESIS
      - FETAL ERYTHROPOIESIS
      - RED CELL LIFE SPAN IN THE FETUS AND NEONATE
    - Chapter 496. Anemias
      - HISTORY AND PHYSICAL EXAMINATION
      - LABORATORY STUDIES
      - DIFFERENTIAL DIAGNOSIS
  - Section 2. Anemias of Inadequate Production
    - Chapter 497. Congenital Hypoplastic Anemia (Diamond-Blackfan Anemia)
      - ETIOLOGY
      - EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
    - Chapter 498. Pearson Syndrome
    - Chapter 499. Acquired Pure Red Blood Cell Anemia
      - TRANSIENT ERYTHROBLASTOPENIA OF CHILDHOOD
      - RED CELL APLASIA ASSOCIATED WITH PARVOVIRUS B19 INFECTION
      - OTHER RED CELL APLASIAS IN CHILDREN
    - Chapter 500. Anemia of Chronic Disease and Renal Disease
      - 500.1. Anemia of Chronic Disease
      - 500.2. Anemia of Renal Disease
    - Chapter 501. Congenital Dyserythropoietic Anemias
      - CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE I
      - CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE II
      - TRANSCRIPTION FACTOR–RELATED CDA
    - Chapter 502. Physiologic Anemia of Infancy
      - TREATMENT
    - Chapter 503. Megaloblastic Anemias
      - 503.1. Folic Acid Deficiency
      - 503.2. Vitamin B12 (Cobalamin) Deficiency
      - 503.3. Other Rare Megaloblastic Anemias
    - Chapter 504. Iron-Deficiency Anemia
      - ETIOLOGY
      - 504.1. Iron-Refractory Iron-Deficiency Anemia
    - Chapter 505. Other Microcytic Anemias
      - INFANTILE POIKILOCYTOSIS AND HEREDITARY PYROPOIKILOCYTOSIS
      - COPPER DEFICIENCY
      - DEFECTS OF IRON METABOLISM
  - Section 3. Hemolytic Anemias
    - Chapter 506. Definitions and Classification of Hemolytic Anemias
    - Chapter 507. Hereditary Spherocytosis
      - ETIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
    - Chapter 508. Hereditary Elliptocytosis, Hereditary Pyropoikilocytosis, and Related Disorders
      - ETIOLOGY
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - TREATMENT
    - Chapter 509. Hereditary Stomatocytosis Syndromes
      - HEREDITARY XEROCYTOSIS
      - HEREDITARY HYDROCYTOSIS
      - INTERMEDIATE SYNDROMES AND OTHER VARIANTS
      - OTHER DISORDERS ASSOCIATED WITH STOMATOCYTOSIS
    - Chapter 510. Paroxysmal Nocturnal Hemoglobinuria and Acanthocytosis
      - PAROXYSMAL NOCTURNAL HEMOGLOBINURIA
      - ACANTHOCYTOSIS
    - Chapter 511. Hemoglobinopathies
      - HEMOGLOBIN DISORDERS
      - 511.1. Sickle Cell Disease
      - 511.2. Sickle Cell Trait (Hemoglobin AS)
      - 511.3. Other Hemoglobinopathies
      - 511.4. Unstable Hemoglobin Disorders
      - 511.5. Abnormal Hemoglobins with Increased Oxygen Affinity
      - 511.6. Abnormal Hemoglobins Causing Cyanosis
      - 511.7. Hereditary Methemoglobinemia
      - 511.8. Hereditary Methemoglobinemia with Deficiency of NADH Cytochrome b5 Reductase
      - 511.9. Syndromes of Hereditary Persistence of Fetal Hemoglobin
      - 511.10. Thalassemia Syndromes
    - Chapter 512. Enzymatic Defects
      - 512.1. Pyruvate Kinase Deficiency
      - 512.2. Other Glycolytic Enzyme Deficiencies
      - 512.3. Glucose-6-Phosphate Dehydrogenase Deficiency and Related Deficiencies
    - Chapter 513. Hemolytic Anemias Resulting from Extracellular Factors—Immune Hemolytic Anemias
      - IMMUNE HEMOLYTIC ANEMIAS
      - AUTOIMMUNE HEMOLYTIC ANEMIAS ASSOCIATED WITH “WARM” ANTIBODIES
      - AUTOIMMUNE HEMOLYTIC ANEMIAS ASSOCIATED WITH “COLD” ANTIBODIES OR COLD AGGLUTININ DISEASE
    - Chapter 514. Hemolytic Anemias Secondary to Other Extracellular Factors
      - FRAGMENTATION HEMOLYSIS
      - THERMAL INJURY
      - RENAL DISEASE
      - LIVER DISEASE
      - TOXINS AND VENOMS
      - WILSON DISEASE
  - Section 4. Polycythemia (Erythrocytosis)
    - Chapter 515. Polycythemia
      - CLONAL POLYCYTHEMIA (POLYCYTHEMIA VERA)
    - Chapter 516. Nonclonal Polycythemia
      - PATHOGENESIS
      - DIAGNOSIS
      - TREATMENT
  - Section 5. The Pancytopenias
    - Chapter 517. Inherited Bone Marrow Failure Syndromes with Pancytopenia
      - FANCONI ANEMIA
      - SHWACHMAN-DIAMOND SYNDROME
      - DYSKERATOSIS CONGENITA
      - CONGENITAL AMEGAKARYOCYTIC THROMBOCYTOPENIA
      - GATA2-RELATED DISORDERS
      - SAMD9/9L-RELATED DISORDER
      - OTHER INHERITED APLASTIC ANEMIAS
      - UNCLASSIFIED INHERITED BONE MARROW FAILURE SYNDROMES
    - Chapter 518. Acquired Pancytopenias
      - ETIOLOGY AND EPIDEMIOLOGY
      - PATHOLOGY AND PATHOGENESIS
      - CLINICAL MANIFESTATIONS, LABORATORY FINDINGS, AND DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - COMPLICATIONS
      - PROGNOSIS
      - PANCYTOPENIA CAUSED BY MARROW REPLACEMENT
  - Section 6. Blood Component Transfusions
    - Chapter 519. Red Blood Cell Transfusions and Erythropoietin Therapy
      - RBC TRANSFUSION IN CHILDREN AND ADOLESCENTS
      - RBC TRANSFUSION IN PRETERM INFANTS AND NEONATES
      - RBC PRODUCT AND DOSE
      - STORAGE AGE OF RBC UNITS
    - Chapter 520. Platelet Transfusions
      - CHILDREN AND ADOLESCENTS
      - INFANTS AND NEONATES
      - PLATELET PRODUCTS AND DOSING
    - Chapter 521. Neutrophil (Granulocyte) Transfusions
      - GRANULOCYTE TRANSFUSIONS FOR CHILDREN
      - GRANULOCYTE TRANSFUSION FOR NEONATES
      - GRANULOCYTE PRODUCT
    - Chapter 522. Plasma Transfusions
      - PLASMA PRODUCTS AND PATIENT TESTING
      - PLASMA TRANSFUSION IN CHILDREN
      - PLASMA TRANSFUSION IN NEONATES
    - Chapter 523. Risks of Blood Transfusions
      - INFECTIOUS RISKS OF TRANSFUSION
      - NONINFECTIOUS RISKS OF TRANSFUSION
  - Section 7. Hemorrhagic and Thrombotic Diseases
    - Chapter 524. Hemostasis
      - THE HEMOSTATIC PROCESS
      - PATHOLOGY
      - 524.1. Clinical and Laboratory Evaluation of Hemostasis
    - Chapter 525. Hereditary Clotting Factor Deficiencies (Bleeding Disorders)
      - 525.1. Factor VIII or Factor IX Deficiency (Hemophilia A or B)
      - 525.2. Factor XI Deficiency
      - 525.3. Deficiencies of the Contact Factors (Nonbleeding Disorders)
      - 525.4. Factor VII Deficiency
      - 525.5. Factor X Deficiency
      - 525.6. Prothrombin (Factor II) Deficiency
      - 525.7. Factor V Deficiency
      - 525.8. Combined Deficiency of Factors V and VIII
      - 525.9. Congenital Fibrinogen Disorders
      - 525.10. Factor XIII Deficiency (Fibrin-Stabilizing Factor or Transglutaminase Deficiency)
      - 525.11. Antiplasmin or Plasminogen Activator Inhibitor Deficiency
    - Chapter 526. Von Willebrand Disease
      - PATHOPHYSIOLOGY
      - CLASSIFICATION
      - LABORATORY DIAGNOSIS
      - TREATMENT
    - Chapter 527. Hereditary Predisposition to Thrombosis
    - Chapter 528. Thrombotic Disorders in Children
      - EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - LABORATORY TESTING
      - TREATMENT
      - COMPLICATIONS
      - 528.1. Anticoagulant and Thrombolytic Therapy
    - Chapter 529. Postneonatal Vitamin K Deficiency
    - Chapter 530. Coagulopathy in Liver Disease
    - Chapter 531. Acquired Inhibitors of Coagulation
      - LABORATORY FINDINGS
      - TREATMENT
    - Chapter 532. Disseminated Intravascular Coagulation
      - ETIOLOGY
      - LABORATORY FINDINGS
      - CLINICAL MANIFESTATIONS
      - MANAGEMENT
    - Chapter 533. Platelet and Blood Vessel Disorders
      - MEGAKARYOPOIESIS
      - THROMBOCYTOPENIA
      - 533.1. Immune Thrombocytopenia
      - 533.2. Drug-Induced Thrombocytopenia
      - 533.3. Nonimmune Platelet Destruction
      - 533.4. Hemolytic-Uremic Syndrome
      - 533.5. Thrombotic Thrombocytopenic Purpura
      - 533.6. Kasabach-Merritt Syndrome
      - 533.7. Sequestration
      - 533.8. Congenital Thrombocytopenic Syndromes
      - 533.9. Neonatal Thrombocytopenia
      - 533.10. Thrombocytopenia From Acquired Disorders Causing Decreased Production
      - 533.11. Platelet Function Disorders
      - 533.12. Acquired Disorders of Platelet Function
      - 533.13. Congenital Abnormalities of Platelet Function
      - 533.14. Disorders of the Blood Vessels
  - Section 8. The Spleen
    - Chapter 534. Anatomy and Function of the Spleen
      - ANATOMY
      - FUNCTION
    - Chapter 535. Splenomegaly
      - CLINICAL MANIFESTATIONS
      - DIFFERENTIAL DIAGNOSIS
    - Chapter 536. Hyposplenism, Splenic Trauma, and Splenectomy
      - HYPOSPLENISM
      - SPLENIC TRAUMA
      - SPLENECTOMY
  - Section 9. The Lymphatic System
    - Chapter 537. Anatomy and Function of the Lymphatic System
    - Chapter 538. Abnormalities of Lymphatic Vessels
      - LYMPHATIC MALFORMATIONS
      - LYMPHEDEMA
      - LYMPHANGIOLEIOMYOMATOSIS
      - LYMPHANGITIS
    - Chapter 539. Lymphadenopathy
      - DIAGNOSIS
      - 539.1. Kikuchi-Fujimoto Disease (Histiocytic Necrotizing Lymphadenitis)
      - 539.2. Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease)
      - 539.3. Castleman Disease (Angiofollicular Lymph Node Hyperplasia)
- Part XX. Cancer and Benign Tumors
  - Chapter 540. Epidemiology of Childhood and Adolescent Cancer
    - INFLUENCING THE INCIDENCE OF CANCER
  - Chapter 541. Molecular and Cellular Biology of Cancer
    - GENES INVOLVED IN ONCOGENESIS
    - SYNDROMES PREDISPOSING TO CANCER
    - OTHER FACTORS ASSOCIATED WITH ONCOGENESIS
  - Chapter 542. Principles of Cancer Diagnosis
    - SIGNS AND SYMPTOMS
    - PHYSICAL EXAMINATION
    - AGE-RELATED MANIFESTATIONS
    - EARLY DETECTION
    - ENSURING THE DIAGNOSIS
    - STAGING
  - Chapter 543. Principles of Cancer Treatment
    - DIAGNOSIS AND STAGING
    - A MULTIMODAL, MULTIDISCIPLINARY APPROACH
    - DISCUSSING THE TREATMENT PLAN WITH THE PATIENT AND FAMILY
    - TREATMENTS
    - ACUTE TOXIC EFFECTS AND SUPPORTIVE CARE
    - LATE EFFECTS
    - PALLIATIVE CARE
  - Chapter 544. The Leukemias
    - INTRODUCTION
    - 544.1. Acute Lymphoblastic Leukemia
    - 544.2. Acute Myelogenous Leukemia
    - 544.3. Down Syndrome and Acute Leukemia and Transient Abnormal Myelopoiesis
    - 544.4. Chronic Myelogenous Leukemia
    - 544.5. Juvenile Myelomonocytic Leukemia
    - 544.6. Infant Leukemia
  - Chapter 545. Lymphoma
    - INTRODUCTION
    - 545.1. Hodgkin Lymphoma
    - 545.2. Non-Hodgkin Lymphoma
    - 545.3. Late Effects in Children and Adolescents with Lymphoma
  - Chapter 546. Central Nervous System Tumors in Childhood
    - ETIOLOGY
    - EPIDEMIOLOGY
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - SPECIFIC TUMORS
    - COMPLICATIONS AND LONG-TERM MANAGEMENT
  - Chapter 547. Neuroblastoma
    - EPIDEMIOLOGY
    - PATHOLOGY
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - TREATMENT
  - Chapter 548. Neoplasms of the Kidney
    - 548.1. Wilms Tumor
    - 548.2. Other Pediatric Renal Tumors
  - Chapter 549. Soft Tissue Sarcomas
    - RHABDOMYOSARCOMA
    - OTHER SOFT TISSUE SARCOMAS
  - Chapter 550. Neoplasms of Bone
    - 550.1. Malignant Tumors of Bone
    - 550.2. Benign Tumors and Tumor-Like Processes of Bone
  - Chapter 551. Retinoblastoma
    - EPIDEMIOLOGY
    - PATHOGENESIS
    - SCREENING
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - TREATMENT
    - PROGNOSIS
  - Chapter 552. Gonadal and Germ Cell Neoplasms
    - EPIDEMIOLOGY
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS AND DIAGNOSIS
    - TREATMENT
    - PROGNOSIS
  - Chapter 553. Neoplasms of the Liver
    - HEPATOBLASTOMA
    - HEPATOCELLULAR CARCINOMA
  - Chapter 554. Complex Vascular Anomalies
    - GENETIC BASIS FOR VASCULAR ANOMALIES
    - COMPLEX LYMPHATIC ANOMALIES
    - COMPLEX VENOUS ANOMALIES
    - SYNDROMES ASSOCIATED WITH VASCULAR ANOMALIES
    - CLOVES
    - AKT-RELATED OVERGROWTH SPECTRUM
    - KAPOSIFORM HEMANGIOENDOTHELIOMA
    - OTHER RARE VASCULAR TUMORS
    - LOCALLY AGGRESSIVE RARE VASCULAR TUMORS
    - MALIGNANT TUMORS
  - Chapter 555. Rare Tumors
    - 555.1. Thyroid Tumors
    - 555.2. Nasopharyngeal Carcinoma
    - 555.3. Adenocarcinoma of the Colon and Rectum
    - 555.4. Adrenal Tumors
    - 555.5. Desmoplastic Small Round Cell Tumor
  - Chapter 556. Histiocytosis Syndromes of Childhood
    - INTRODUCTION
    - CLASSIFICATION AND PATHOLOGY
    - 556.1. Langerhans Cell Histiocytosis
    - 556.2. Hemophagocytic Lymphohistiocytosis
    - 556.3. Other Histiocytoses
- Nephrology
  - Section 1. Glomerular Disease
    - Chapter 557. Introduction to Glomerular Diseases
      - 557.1. Anatomy of the Glomerulus
      - 557.2. Glomerular Filtration
      - 557.3. Glomerular Diseases
  - Section 2. Conditions Particularly Associated With Hematuria
    - Chapter 558. Clinical Evaluation of the Child with Hematuria
    - Chapter 559. Isolated Glomerular Diseases Associated with Recurrent Gross Hematuria
      - Introduction
      - 559.1. Immunoglobulin A Nephropathy (Berger Nephropathy)
      - 559.2. Alport Syndrome
      - 559.3. Thin Basement Membrane Disease
      - 559.4. Acute Poststreptococcal Glomerulonephritis
      - 559.5. Membranous Nephropathy
      - 559.6. Membranoproliferative Glomerulonephritis
      - 559.7. Rapidly Progressive (Crescentic) Glomerulonephritis
    - Chapter 560. Multisystem Disease Associated with Hematuria
      - 560.1. Chronic Infections
      - 560.2. Glomerulonephritis Associated with Systemic Lupus Erythematosus
      - 560.3. IgA Vasculitis Nephritis
      - 560.4. Goodpasture Disease
      - 560.5. Hemolytic-Uremic Syndrome
      - 560.6. Toxic Nephropathy
      - 560.7. Cortical Necrosis
      - 560.8. Coagulopathies and Thrombocytopenia
    - Chapter 561. Tubulointerstitial Disease Associated with Hematuria
      - 561.1. Pyelonephritis
      - 561.2. Tubulointerstitial Nephritis
      - 561.3. Papillary Necrosis
      - 561.4. Acute Tubular Necrosis
    - Chapter 562. Vascular Diseases Associated with Hematuria
      - 562.1. Vascular Abnormalities
      - 562.2. Renal Vein Thrombosis
      - 562.3. Sickle Cell Nephropathy
      - 562.4. Idiopathic Hypercalciuria
      - 562.5. Nephrocalcinosis
    - Chapter 563. Anatomic Abnormalities Associated with Hematuria
      - 563.1. Congenital Anomalies
      - 563.2. Autosomal Recessive Polycystic Kidney Disease
      - 563.3. Autosomal Dominant Polycystic Kidney Disease
      - 563.4. Trauma
      - 563.5. Renal Tumors
    - Chapter 564. Lower Urinary Tract Causes of Hematuria
      - 564.1. Infectious Causes of Cystitis and Urethritis
      - 564.2. Hemorrhagic Cystitis
      - 564.3. Vigorous Exercise
  - Section 3. Conditions Particularly Associated With Proteinuria
    - Chapter 565. Clinical Evaluation of the Child with Proteinuria
      - NORMAL PHYSIOLOGY
      - PATHOPHYSIOLOGY OF PROTEINURIA
      - MEASUREMENT OF URINE PROTEIN
      - CLINICAL CONSIDERATIONS
    - Chapter 566. Conditions Associated with Proteinuria
      - 566.1. Transient Proteinuria
      - 566.2. Orthostatic (Postural) Proteinuria
      - 566.3. Fixed Proteinuria
    - Chapter 567. Nephrotic Syndrome
      - ETIOLOGY
      - 567.1. Idiopathic Nephrotic Syndrome
      - 567.2. Secondary Nephrotic Syndrome
      - 567.3. Congenital Nephrotic Syndrome
  - Section 4. Tubular Disorders
    - Chapter 568. Tubular Function
      - SODIUM
      - POTASSIUM
      - CALCIUM
      - PHOSPHATE
      - MAGNESIUM
      - ACIDIFICATION AND CONCENTRATING MECHANISMS
      - DEVELOPMENTAL CONSIDERATIONS
    - Chapter 569. Renal Tubular Acidosis
      - NORMAL URINARY ACIDIFICATION
      - 569.1. Proximal (Type II) Renal Tubular Acidosis
      - 569.2. Distal (Type I) Renal Tubular Acidosis
      - 569.3. Hyperkalemic (Type IV) Renal Tubular Acidosis
      - 569.4. Rickets Associated with Renal Tubular Acidosis
    - Chapter 570. Nephrogenic Diabetes Insipidus
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - TREATMENT AND PROGNOSIS
    - Chapter 571. Inherited Tubular Transport Abnormalities
      - 571.1. Bartter Syndrome
      - 571.2. Gitelman Syndrome
      - 571.3. Other Inherited Tubular Transport Abnormalities
    - Chapter 572. Renal Failure
      - 572.1. Acute Kidney Injury
      - 572.2. Chronic Kidney Disease
      - 572.3. End-Stage Kidney Disease
    - Chapter 573. Renal Transplantation
      - INCIDENCE AND ETIOLOGY OF ESKD
      - INDICATIONS FOR RENAL TRANSPLANTATION
      - CHARACTERISTICS OF KIDNEY DONORS AND RECIPIENTS
      - EVALUATION AND PREPARING FOR KIDNEY TRANSPLANTATION
      - IMMUNOSUPPRESSION
      - FLUID MANAGEMENT IN INFANTS AND SMALL CHILDREN AFTER KIDNEY TRANSPLANTATION
      - REJECTION OF KIDNEY TRANSPLANT
      - GRAFT SURVIVAL OF KIDNEYS
      - COMPLICATIONS OF IMMUNOSUPPRESSION
      - LONG-TERM OUTCOME OF KIDNEY TRANSPLANTATION
- Part XXII. Urologic Disorders in Infants and Children
  - Chapter 574. Congenital Anomalies and Dysgenesis of the Kidneys
    - EMBRYONIC AND FETAL DEVELOPMENT
    - RENAL AGENESIS
    - RENAL DYSGENESIS: DYSPLASIA, HYPOPLASIA, AND CYSTIC ANOMALIES
    - RENAL CYSTS IN CHILDREN
    - ANOMALIES IN SHAPE AND POSITION
    - ASSOCIATED PHYSICAL FINDINGS
  - Chapter 575. Urinary Tract Infections
    - PREVALENCE AND ETIOLOGY
    - CLINICAL MANIFESTATIONS AND CLASSIFICATION
    - PATHOGENESIS AND PATHOLOGY
    - DIAGNOSIS
    - IMAGING FINDINGS
    - TREATMENT
    - IMAGING STUDIES IN CHILDREN WITH A FEBRILE UTI
    - PREVENTION OF RECURRENCES
  - Chapter 576. Vesicoureteral Reflux
    - CLASSIFICATION
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - NATURAL HISTORY
    - TREATMENT
    - CURRENT VESICOURETERAL REFLUX GUIDELINES
  - Chapter 577. Obstruction of the Urinary Tract
    - ETIOLOGY
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - PHYSICAL FINDINGS
    - IMAGING STUDIES
    - SPECIFIC TYPES OF URINARY TRACT OBSTRUCTION AND THEIR TREATMENT
  - Chapter 578. Anomalies of the Bladder
    - BLADDER EXSTROPHY
    - OTHER EXSTROPHY ANOMALIES
    - BLADDER DIVERTICULA
    - URACHAL ANOMALIES
  - Chapter 579. Neuropathic Bladder
    - NEURAL TUBE DEFECTS
    - ASSOCIATED DISORDERS
  - Chapter 580. Enuresis and Voiding Dysfunction
    - NORMAL VOIDING AND TOILET TRAINING
    - DIURNAL INCONTINENCE
    - OVERACTIVE BLADDER (DIURNAL URGE SYNDROME)
    - NONNEUROGENIC NEUROGENIC BLADDER (HINMAN SYNDROME)
    - INFREQUENT VOIDING (UNDERACTIVE BLADDER)
    - VAGINAL VOIDING
    - OTHER CAUSES OF INCONTINENCE IN FEMALES
    - VOIDING DISORDERS WITHOUT INCONTINENCE
    - NOCTURNAL ENURESIS
  - Chapter 581. Anomalies of the Penis and Urethra
    - HYPOSPADIAS
    - CHORDEE WITHOUT HYPOSPADIAS
    - PHIMOSIS AND PARAPHIMOSIS
    - CIRCUMCISION
    - PENILE TORSION
    - INCONSPICUOUS PENIS
    - MICROPENIS
    - PRIAPISM
    - OTHER PENILE ANOMALIES
    - MEATAL STENOSIS
    - OTHER MALE URETHRAL ANOMALIES
    - URETHRAL PROLAPSE (FEMALE)
    - OTHER FEMALE URETHRAL LESIONS
  - Chapter 582. Disorders and Anomalies of the Scrotal Contents
    - UNDESCENDED TESTIS (CRYPTORCHIDISM)
    - SCROTAL SWELLING
    - TESTICULAR (SPERMATIC CORD) TORSION
    - TORSION OF THE APPENDIX TESTIS/EPIDIDYMIS
    - EPIDIDYMITIS
    - VARICOCELE
    - SPERMATOCELE
    - HYDROCELE
    - INGUINAL HERNIA
    - TESTICULAR MICROLITHIASIS
    - TESTICULAR TUMOR
  - Chapter 583. Trauma to the Genitourinary Tract
    - DIAGNOSIS
    - TREATMENT
  - Chapter 584. Urinary Lithiasis
    - STONE FORMATION
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - METABOLIC EVALUATION
    - PATHOGENESIS OF SPECIFIC RENAL CALCULI
    - TREATMENT
    - STONE PREVENTION
- Part XXIII. Gynecologic Problems of Childhood
  - Chapter 585. Gynecologic History and Physical Examination
    - HISTORY
    - GYNECOLOGIC EXAMINATION
  - Chapter 586. Vulvovaginitis
    - ETIOLOGY
    - EPIDEMIOLOGY
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
    - TREATMENT AND PREVENTION
  - Chapter 587. Vaginal Bleeding in the Prepubertal Child
  - Chapter 588. Breast Health
    - BREAST DEVELOPMENT
    - BREAST EXAMINATION
    - BREAST SELF-AWARENESS
    - ABNORMAL DEVELOPMENT
    - BREAST MASSES
    - MANAGEMENT OF BREAST MASSES
  - Chapter 589. Polycystic Ovary Syndrome and Hirsutism
    - POLYCYSTIC OVARY SYNDROME
    - HIRSUTISM
  - Chapter 590. Gynecologic Neoplasms and Prevention Methods for Human Papillomavirus Infections in Adolescents
    - OVERVIEW OF GYNECOLOGIC MALIGNANCIES IN CHILDREN AND ADOLESCENTS
    - IMPACT OF CANCER THERAPY ON FERTILITY
    - NEONATAL AND PEDIATRIC OVARIAN CYSTS
    - OVARIAN NEOPLASMS
    - OVARIAN MALIGNANCIES
    - UTERINE MALIGNANCIES
    - VAGINAL MALIGNANCIES
    - VULVAR MALIGNANCIES
    - CERVICAL MALIGNANCIES AND THEIR PREVENTION
  - Chapter 591. Vulvovaginal and Müllerian Anomalies
    - EMBRYOLOGY
    - EPIDEMIOLOGY
    - CLINICAL MANIFESTATIONS
    - LABORATORY AND RADIOGRAPHIC FINDINGS
    - UTERINE ANOMALIES
    - VAGINAL ANOMALIES
    - CERVICAL ANOMALIES
    - VULVAR AND OTHER ANOMALIES
  - Chapter 592. Gynecologic Care for Adolescents with Special Needs
    - SEXUALITY AND SEXUAL EDUCATION
    - ABUSE
    - PELVIC EXAMINATION
    - MENSTRUATION
    - CONTRACEPTION
  - Chapter 593. Female Genital Mutilation
    - COMPLICATIONS
    - CLINICAL MANAGEMENT OF FGM
- The Endocrine System
  - Section 1. Disorders of the Hypothalamus and Pituitary Gland
    - Chapter 594. Hormones of the Hypothalamus and Pituitary
      - ANATOMY
      - EMBRYOLOGY
      - VASCULAR SUPPLY
      - ANTERIOR PITUITARY CELL TYPES
      - POSTERIOR PITUITARY CELL TYPES
    - Chapter 595. Hypopituitarism
      - MULTIPLE PITUITARY HORMONE DEFICIENCY
      - ISOLATED GROWTH HORMONE DEFICIENCY AND INSENSITIVITY
      - GROWTH HORMONE INSENSITIVITY
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - RADIOLOGIC FINDINGS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - COMPLICATIONS AND ADVERSE EFFECTS OF GROWTH HORMONE TREATMENT
    - Chapter 596. Diabetes Insipidus
      - PHYSIOLOGY OF WATER BALANCE
      - APPROACH TO THE PATIENT WITH POLYURIA, POLYDIPSIA, AND HYPERNATREMIA
      - CAUSES OF HYPERNATREMIA
      - TREATMENT OF CENTRAL DIABETES INSIPIDUS
      - TREATMENT OF NEPHROGENIC DIABETES INSIPIDUS
    - Chapter 597. Other Abnormalities of Arginine Vasopressin Metabolism and Action
      - CAUSES OF HYPONATREMIA
      - TREATMENT
    - Chapter 598. Hyperpituitarism
      - SECONDARY HYPERPITUITARISM
      - EXCESS GROWTH HORMONE SECRETION AND PITUITARY GIGANTISM
      - TREATMENT OF NORMAL-VARIANT TALL STATURE
      - HYPERSECRETION OF OTHER PITUITARY HORMONES
      - 598.1. Overgrowth Syndromes
    - Chapter 599. Physiology of Puberty
    - Chapter 600. Disorders of Pubertal Development
      - INTRODUCTION
      - 600.1. Central Precocious Puberty
      - 600.2. Precocious Puberty Resulting from Organic Brain Lesions
      - 600.3. Precocious Puberty After Irradiation of the Brain
      - 600.4. Syndrome of Precocious Puberty and Hypothyroidism
      - 600.5. Chorionic Gonadotropin-Secreting Tumors: Paraneoplastic Precocious Puberty
      - 600.6. McCune-Albright Syndrome
      - 600.7. Familial Male-Limited Gonadotropin-Independent Precocious Puberty
      - 600.8. Incomplete (Partial) Precocious Development
      - 600.9. Medicational Precocity
      - 600.10. Delayed or Absent Puberty
  - Section 2. Disorders of the Thyroid Gland
    - Chapter 601. Thyroid Development and Physiology
      - FETAL DEVELOPMENT
      - 601.1. Thyroid Hormone Studies
    - Chapter 602. Disorders of Thyroxine-Binding Globulin
    - Chapter 603. Hypothyroidism
      - CONGENITAL HYPOTHYROIDISM
      - ACQUIRED HYPOTHYROIDISM
    - Chapter 604. Thyroiditis
      - THYROIDITIS WITH PAIN
      - THYROIDITIS WITHOUT PAIN
      - OTHER CAUSES OF THYROIDITIS
    - Chapter 605. Goiter
      - 605.1. Congenital Goiter
      - 605.2. Intratracheal Goiter
      - 605.3. Endemic Goiter and Cretinism
      - 605.4. Acquired Goiter
    - Chapter 606. Thyrotoxicosis
      - 606.1. Graves Disease
      - 606.2. Congenital Hyperthyroidism
    - Chapter 607. Carcinoma of the Thyroid
      - PATHOGENESIS
      - 607.1. Thyroid Nodules
    - Chapter 608. Autoimmune Polyglandular Syndromes
      - MONOGENIC AUTOIMMUNE POLYGLANDULAR SYNDROMES
      - AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 1
      - IMMUNE DYSREGULATION-POLYENDOCRINOPATHY-ENTEROPATHY X-LINKED
      - OTHER MONOGENIC IMMUNE DYSREGULATION DISORDERS
      - POLYGENIC AUTOIMMUNE POLYGLANDULAR SYNDROME
      - CHROMOSOMAL ABNORMALITIES ASSOCIATED WITH AUTOIMMUNE POLYGLANDULAR SYNDROME
      - NONGENETIC AUTOIMMUNE CAUSES OF MULTIPLE ENDOCRINOPATHY
    - Chapter 609. Multiple Endocrine Neoplasia Syndromes
      - MULTIPLE ENDOCRINE NEOPLASIA TYPE 1
      - MULTIPLE ENDOCRINE NEOPLASIA TYPE 2
      - MULTIPLE ENDOCRINE NEOPLASIA TYPE 2A
      - MULTIPLE ENDOCRINE NEOPLASIA TYPE 2B
      - FAMILIAL MEDULLARY THYROID CARCINOMA
      - MANAGEMENT OF MULTIPLE ENDOCRINE NEOPLASIA TYPE 2
  - Section 3. Disorders of the Parathyroid Gland
    - Chapter 610. Hormones and Peptides of Calcium Homeostasis and Bone Metabolism
      - PARATHYROID HORMONE
      - PARATHYROID HORMONE–RELATED PEPTIDE
      - VITAMIN D
      - CALCITONIN
    - Chapter 611. Hypoparathyroidism
      - APLASIA OR HYPOPLASIA OF THE PARATHYROID GLANDS
      - X-LINKED RECESSIVE HYPOPARATHYROIDISM
      - AUTOSOMAL RECESSIVE HYPOPARATHYROIDISM WITH DYSMORPHIC FEATURES
      - HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL ANOMALY SYNDROME
      - SUPPRESSION OF NEONATAL PARATHYROID HORMONE SECRETION BECAUSE OF MATERNAL HYPERPARATHYROIDISM OR MATERNAL FAMILIAL HYPOCALCIURIC HYPERCALCEMIA
      - AUTOSOMAL DOMINANT HYPOPARATHYROIDISM
      - HYPOPARATHYROIDISM ASSOCIATED WITH MITOCHONDRIAL DISORDERS
      - SURGICAL OR INFILTRATIVE HYPOPARATHYROIDISM
      - AUTOIMMUNE HYPOPARATHYROIDISM
      - IDIOPATHIC HYPOPARATHYROIDISM
    - Chapter 612. Pseudohypoparathyroidism
      - TYPE Ia
      - TYPE Ib
      - ACRODYSOSTOSIS WITH HORMONE RESISTANCE
    - Chapter 613. Hyperparathyroidism
      - ETIOLOGY
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
      - 613.1. Other Causes of Hypercalcemia
  - Section 4. Disorders of the Adrenal Gland
    - Chapter 614. Physiology of the Adrenal Gland
      - 614.1. Histology and Embryology
      - 614.2. Adrenal Steroid Biosynthesis
      - 614.3. Regulation of the Adrenal Cortex
      - 614.4. Adrenal Steroid Hormone Actions
      - 614.5. Adrenal Medulla
    - Chapter 615. Adrenocortical Insufficiency and Altered Sensitivity to Corticosteroids
      - 615.1. Primary Adrenal Insufficiency
      - 615.2. Secondary and Tertiary Adrenal Insufficiency
      - 615.3. Adrenal Insufficiency in the Critical Care Setting
      - 615.4. Altered End-Organ Sensitivity to Corticosteroids
    - Chapter 616. Congenital Adrenal Hyperplasia and Related Disorders
      - 616.1. Congenital Adrenal Hyperplasia Caused by 21-Hydroxylase Deficiency
      - 616.2. Congenital Adrenal Hyperplasia Caused by 11β-Hydroxylase Deficiency
      - 616.3. Congenital Adrenal Hyperplasia Caused by 3β-Hydroxysteroid Dehydrogenase Deficiency
      - 616.4. Congenital Adrenal Hyperplasia Caused by 17-Hydroxylase Deficiency
      - 616.5. Lipoid Adrenal Hyperplasia
      - 616.6. Deficiency of P450 Oxidoreductase (Antley-Bixler Syndrome)
      - 616.7. Aldosterone Synthase Deficiency
      - 616.8. Glucocorticoid-Remediable Aldosteronism
    - Chapter 617. Adrenocortical Tumors and Masses
      - 617.1. Adrenocortical Carcinoma
      - 617.2. Adrenal Incidentaloma
      - 617.3. Adrenal Calcification
    - Chapter 618. Virilizing and Feminizing Adrenal Tumors
      - LABORATORY FINDINGS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
    - Chapter 619. Cushing Syndrome
      - ETIOLOGY
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
    - Chapter 620. Primary Aldosteronism
      - EPIDEMIOLOGY
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
    - Chapter 621. Pheochromocytoma
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
  - Section 5. Disorders of the Gonads
    - Chapter 622. Development and Function of the Gonads
      - GENETIC CONTROL OF EMBRYONIC GONADAL DIFFERENTIATION
      - FUNCTION OF THE TESTES
      - FUNCTION OF THE OVARIES
      - DIAGNOSTIC TESTING
    - Chapter 623. Hypofunction of the Testes
      - 623.1. Hypergonadotropic Hypogonadism in the Male (Primary Hypogonadism)
      - 623.2. Hypogonadotropic Hypogonadism in the Male (Secondary Hypogonadism)
    - Chapter 624. Pseudoprecocity Resulting from Tumors of the Testes
    - Chapter 625. Gynecomastia
      - PHYSIOLOGIC FORMS OF GYNECOMASTIA
      - EVALUATION OF GYNECOMASTIA
      - TREATMENT
    - Chapter 626. Hypofunction of the Ovaries
      - 626.1. Hypergonadotropic Hypogonadism in the Female (Primary Hypogonadism)
      - 626.2. Hypogonadotropic Hypogonadism in the Female (Secondary Hypogonadism)
    - Chapter 627. Pseudoprecocity Resulting from Lesions of the Ovary
      - ESTROGENIC LESIONS OF THE OVARY
      - ANDROGENIC LESIONS OF THE OVARY
    - Chapter 628. Disorders of Sex Development
      - SEX DIFFERENTIATION
      - 628.1. 46,XX DSD
      - 628.2. 46,XY DSD
      - 628.3. Ovotesticular DSD
  - Section 6. Diabetes Mellitus in Children
    - Chapter 629. Diabetes Mellitus
      - 629.1. Classification of Diabetes Mellitus
      - 629.2. Type 1 Diabetes Mellitus (Immune Mediated)
      - 629.3. Type 2 Diabetes Mellitus
      - 629.4. Other Specific Types of Diabetes
- Part XXV. The Nervous System
  - Chapter 630. Neurologic Evaluation
    - HISTORY
    - NEUROLOGIC EXAMINATION
    - GENERAL EXAMINATION
    - SPECIAL DIAGNOSTIC PROCEDURES
  - Chapter 631. Congenital Anomalies of the Central Nervous System
    - 631.1. Neural Tube Defects
    - 631.2. Myelomeningocele
    - 631.3. Occult Spinal Dysraphism
    - 631.4. Encephalocele
    - 631.5. Anencephaly
    - 631.6. Malformations of Cortical Development
    - 631.7. Disorders with Midline Defects
    - 631.8. Dysgenesis of the Cranial Nerves and the Posterior Fossa
    - 631.9. Hydrocephalus
    - 631.10. Craniosynostosis
  - Chapter 632. Deformational Plagiocephaly
    - EPIDEMIOLOGY AND ETIOLOGY
    - EXAMINATION AND DIFFERENTIATING BETWEEN DEFORMATIONAL PLAGIOCEPHALY AND CRANIOSYNOSTOSIS
    - TREATMENT
    - OUTCOMES
  - Chapter 633. Seizures in Childhood
    - EVALUATION OF THE FIRST SEIZURE
    - 633.1. Febrile Seizures
    - 633.2. Unprovoked Seizures
    - 633.3. Focal Seizures and Related Epilepsy Syndromes
    - 633.4. Generalized Seizures and Related Epilepsy Syndromes
    - 633.5. Mechanisms of Seizures
    - 633.6. Treatment of Seizures and Epilepsy
    - 633.7. Neonatal Seizures
    - 633.8. Status Epilepticus
    - 633.9. Reflex Seizures (Stimulus-Precipitated Seizures)
    - 633.10. Nodding Syndrome
  - Chapter 634. Conditions That Mimic Seizures
    - SYNCOPE AND OTHER GENERALIZED PAROXYSMS
    - MOVEMENT DISORDERS AND OTHER PAROXYSMAL MOVEMENTS AND POSTURES
    - OCULOMOTOR AND VISUAL ABNORMALITIES
    - SLEEP-RELATED DISORDERS (see also Chapter 31)
  - Chapter 635. Headaches
    - 635.1. Migraine
    - 635.2. Secondary Headaches
    - 635.3. Tension-Type Headaches
  - Chapter 636. Neurocutaneous Syndromes
    - 636.1. Neurofibromatosis
    - 636.2. Tuberous Sclerosis
    - 636.3. Sturge-Weber Syndrome
    - 636.4. Von Hippel-Lindau Disease
    - 636.5. Linear Nevus Sebaceous Syndrome
    - 636.6. PHACE Syndrome
    - 636.7. Incontinentia Pigmenti
  - Chapter 637. Movement Disorders
    - Introduction
    - 637.1. Ataxias
    - 637.2. Chorea, Athetosis, and Tremor
    - 637.3. Myoclonus
    - 637.4. Dystonia
  - Chapter 638. Encephalopathies
    - 638.1. Cerebral Palsy
    - 638.2. Mitochondrial Encephalomyopathies
    - 638.3. Other Encephalopathies
    - 638.4. Autoimmune Encephalitis
  - Chapter 639. Neurodegenerative Disorders of Childhood
    - 639.1. Sphingolipidoses
    - 639.2. Neuronal Ceroid Lipofuscinoses
    - 639.3. Adrenoleukodystrophy
    - 639.4. Sialidosis
    - 639.5. Miscellaneous Neurodegenerative Disorders
  - Chapter 640. Demyelinating Disorders of the Central Nervous System
    - Introduction
    - 640.1. Acute Disseminated Encephalomyelitis
    - 640.2. Optic Neuritis
    - 640.3. Transverse Myelitis
    - 640.4. Multiple Sclerosis
    - 640.5. Myelin Oligodendrocyte Glycoprotein–Associated Disorders
    - 640.6. Neuromyelitis Optica Spectrum Disorders
  - Chapter 641. Pediatric Stroke
    - 641.1. Arterial Ischemic Stroke
    - 641.2. Cerebral Sinovenous Thrombosis
    - 641.3. Spinal Cord Lesions Associated with Vascular Processes
    - 641.4. Hemorrhagic Stroke
    - 641.5. Differential Diagnosis of Strokelike Events
  - Chapter 642. Central Nervous System Vasculitis
    - EPIDEMIOLOGY
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - TREATMENT
    - PROGNOSIS
  - Chapter 643. Central Nervous System Infections
    - 643.1. Acute Bacterial Meningitis Beyond the Neonatal Period
    - 643.2. Viral Meningoencephalitis
    - 643.3. Eosinophilic Meningitis
  - Chapter 644. Brain Abscess
    - PATHOLOGY
    - ETIOLOGY
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - TREATMENT
    - PROGNOSIS
  - Chapter 645. Idiopathic Intracranial Hypertension (Pseudotumor Cerebri)
    - ETIOLOGY
    - CLINICAL MANIFESTATIONS
    - TREATMENT
  - Chapter 646. Spinal Cord Disorders
    - 646.1. Tethered Cord
    - 646.2. Diastematomyelia (Split-Cord Malformation)
    - 646.3. Syringomyelia
    - 646.4. Spinal Cord Tumors
    - 646.5. Spinal Arteriovenous Malformations
- Part XXVI. Neuromuscular Disorders
  - Chapter 647. Evaluation and Investigation of Neuromuscular Disorders
    - GENETIC TESTING
    - CLINICAL MANIFESTATIONS
    - LABORATORY FINDINGS
    - IMAGING OF MUSCLES AND THE CENTRAL NERVOUS SYSTEM
    - MUSCLE BIOPSY
    - NERVE BIOPSY
    - CARDIAC ASSESSMENT
  - Chapter 648. Developmental Disorders of Muscle
    - MYOGENIC REGULATORY GENES AND GENETIC LOCI OF INHERITED DISEASES OF MUSCLE
    - 648.1. Myotubular Myopathy (Centronuclear Myopathy)
    - 648.2. Congenital Muscle Fiber–Type Disproportion
    - 648.3. Nemaline Rod Myopathy
    - 648.4. Core Myopathies
    - 648.5. Myofibrillar Myopathies
    - 648.6. Brain Malformations and Muscle Development
    - 648.7. Amyoplasia
    - 648.8. Muscular Dysgenesis (Proteus Syndrome Myopathy)
    - 648.9. Benign Congenital Hypotonia
    - 648.10. Arthrogryposis
  - Chapter 649. Muscular Dystrophies
    - 649.1. Duchenne and Becker Muscular Dystrophies
    - 649.2. Emery-Dreifuss Muscular Dystrophy/Laminopathies
    - 649.3. Myotonic Muscular Dystrophy
    - 649.4. Limb-Girdle Muscular Dystrophies
    - 649.5. Facioscapulohumeral Muscular Dystrophy
    - 649.6. Congenital Muscular Dystrophies
  - Chapter 650. Endocrine and Toxic Myopathies
    - THYROID MYOPATHIES
    - STEROID-HORMONE INDUCED MYOPATHY
    - STATIN-INDUCED RHABDOMYOLYSIS WITH MYOGLOBINURIA
    - MITOCHONDRIAL DYSFUNCTION IN TOXIC MYOPATHIES
    - CRITICAL ILLNESS MYOPATHY
  - Chapter 651. Metabolic Myopathies and Channelopathies
    - 651.1. Periodic Paralyses and Other Muscle Channelopathies
    - 651.2. Malignant Hyperthermia
    - 651.3. Glycogenoses
    - 651.4. Mitochondrial Myopathies
    - 651.5. Lipid Myopathies
    - 651.6. Vitamin E Deficiency Myopathy
  - Chapter 652. Disorders of Neuromuscular Transmission and of Motor Neurons
    - 652.1. Myasthenia Gravis
    - 652.2. Spinal Muscular Atrophies
    - 652.3. Other Motor Neuron Diseases
  - Chapter 653. Hereditary Motor-Sensory Neuropathies
    - Introduction
    - 653.1. Peroneal Muscular Atrophy (Charcot-Marie-Tooth Disease, HMSN Type IIa)
    - 653.2. Peroneal Muscular Atrophy (Axonal Type)
    - 653.3. Congenital Hypomyelinating Neuropathy and Déjèrine-Sottas Disease (HMSN Type III)
    - 653.4. Roussy-Lévy Syndrome
    - 653.5. Refsum Disease (HMSN Type IV) and Infantile Refsum Disease
    - 653.6. Fabry Disease
    - 653.7. Giant Axonal Neuropathy
    - 653.8. Hypermyelinating (Tomaculous) Neuropathy; Hereditary Neuropathy with Liability to Pressure Palsies
    - 653.9. Leukodystrophies
    - 653.10. Congenital Hereditary Sensory Pain Syndromes
  - Chapter 654. Toxic Neuropathies
  - Chapter 655. Autonomic Neuropathies
    - 655.1. Familial Dysautonomia
    - 655.2. Other Autonomic Neuropathies
  - Chapter 656. Guillain-Barré Syndrome
    - CLINICAL MANIFESTATIONS
    - LABORATORY FINDINGS AND DIAGNOSIS
    - TREATMENT
    - PROGNOSIS
  - Chapter 657. Bell Palsy
    - CLINICAL MANIFESTATIONS
    - TREATMENT
    - PROGNOSIS
    - FACIAL PALSY AT BIRTH
- Part XXVII. Disorders of the Eye
  - Chapter 658. Growth and Development of the Eye
  - Chapter 659. Examination of the Eye
    - VISUAL ACUITY
    - VISUAL FIELD ASSESSMENT
    - COLOR VISION TESTING
    - PUPILLARY EXAMINATION
    - OCULAR MOTILITY
    - BINOCULAR VISION
    - EXTERNAL EXAMINATION
    - BIOMICROSCOPY (SLIT-LAMP EXAMINATION)
    - FUNDUS EXAMINATION (OPHTHALMOSCOPY)
    - REFRACTION
    - TONOMETRY
  - Chapter 660. Abnormalities of Refraction and Accommodation
    - HYPEROPIA
    - MYOPIA
    - ASTIGMATISM
    - ANISOMETROPIA
    - ACCOMMODATION
  - Chapter 661. Disorders of Vision
    - AMBLYOPIA
    - DIPLOPIA
    - SUPPRESSION
    - AMAUROSIS
    - NYCTALOPIA
    - PSYCHOGENIC DISTURBANCES
    - DYSLEXIA
  - Chapter 662. Abnormalities of Pupil and Iris
    - ANIRIDIA
    - COLOBOMA OF THE IRIS
    - MICROCORIA
    - CONGENITAL MYDRIASIS
    - DYSCORIA AND CORECTOPIA
    - ANISOCORIA
    - DILATED FIXED PUPIL
    - TONIC PUPIL
    - MARCUS GUNN PUPIL
    - HORNER SYNDROME
    - PARADOXICAL PUPIL REACTION
    - PERSISTENT PUPILLARY MEMBRANE
    - HETEROCHROMIA
    - OTHER IRIS LESIONS
    - LEUKOCORIA
  - Chapter 663. Disorders of Eye Movement and Alignment
    - STRABISMUS
    - CONGENITAL OCULAR MOTOR APRAXIA
    - NYSTAGMUS
    - OTHER ABNORMAL EYE MOVEMENTS
  - Chapter 664. Abnormalities of the Lids
    - PTOSIS
    - EPICANTHAL FOLDS
    - LAGOPHTHALMOS
    - LID RETRACTION
    - ECTROPION, ENTROPION, AND EPIBLEPHARON
    - BLEPHAROSPASM
    - BLEPHARITIS
    - HORDEOLUM (STYE)
    - CHALAZION
    - COLOBOMA OF THE EYELID
    - TUMORS OF THE LID
  - Chapter 665. Disorders of the Lacrimal System
    - THE TEAR FILM
    - DACRYOSTENOSIS
    - ALACRIMA AND “DRY EYE”
  - Chapter 666. Disorders of the Conjunctiva
    - CONJUNCTIVITIS
    - OTHER CONJUNCTIVAL DISORDERS
  - Chapter 667. Abnormalities of the Cornea
    - MEGALOCORNEA
    - MICROCORNEA
    - KERATOCONUS
    - NEONATAL CORNEAL OPACITIES
    - SCLEROCORNEA
    - PETERS ANOMALY
    - CORNEAL DYSTROPHIES
    - DERMOIDS
    - DENDRITIC KERATITIS
    - CORNEAL ULCERS
    - PHLYCTENULES
    - INTERSTITIAL KERATITIS
    - CORNEAL MANIFESTATIONS OF SYSTEMIC DISEASE
  - Chapter 668. Abnormalities of the Lens
    - CATARACTS
    - ECTOPIA LENTIS
    - OTHER DISORDERS OF THE LENS
  - Chapter 669. Disorders of the Uveal Tract
    - UVEITIS (IRITIS, CYCLITIS, CHORIORETINITIS)
  - Chapter 670. Disorders of the Retina and Vitreous
    - RETINOPATHY OF PREMATURITY
    - PERSISTENT FETAL VASCULATURE
    - RETINOBLASTOMA
    - INHERITED RETINAL DYSTROPHIES
    - STARGARDT DISEASE (FUNDUS FLAVIMACULATUS)
    - BEST VITELLIFORM DEGENERATION
    - CHERRY-RED SPOT
    - PHAKOMATOSIS
    - RETINOSCHISIS
    - RETINAL DETACHMENT
    - COATS DISEASE
    - FAMILIAL EXUDATIVE VITREORETINOPATHY
    - HYPERTENSIVE RETINOPATHY
    - DIABETIC RETINOPATHY
    - SUBACUTE BACTERIAL ENDOCARDITIS
    - BLOOD DISORDERS
    - TRAUMA-RELATED RETINOPATHY
    - MYELINATED NERVE FIBERS
    - CHORIORETINAL COLOBOMA
  - Chapter 671. Abnormalities of the Optic Nerve
    - OPTIC NERVE APLASIA
    - OPTIC NERVE HYPOPLASIA
    - OPTIC NERVE COLOBOMA
    - MORNING GLORY DISC ANOMALY
    - TILTED DISC
    - DRUSEN OF THE OPTIC NERVE
    - PAPILLEDEMA
    - OPTIC NEURITIS
    - LEBER HEREDITARY OPTIC NEUROPATHY
    - OPTIC ATROPHY
    - OPTIC NERVE GLIOMA
    - TRAUMATIC OPTIC NEUROPATHIES
  - Chapter 672. Childhood Glaucoma
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS AND TREATMENT
  - Chapter 673. Orbital Abnormalities
    - HYPERTELORISM AND HYPOTELORISM
    - EXOPHTHALMOS AND ENOPHTHALMOS
    - ORBITAL INFLAMMATION
    - TUMORS OF THE ORBIT
  - Chapter 674. Orbital Infections
    - DACRYOADENITIS
    - DACRYOCYSTITIS
    - PRESEPTAL CELLULITIS
    - ORBITAL CELLULITIS
    - ENDOPHTHALMITIS
  - Chapter 675. Injuries to the Eye
    - ECCHYMOSIS AND SWELLING OF THE EYELIDS
    - LACERATIONS OF THE EYELIDS
    - SUPERFICIAL ABRASIONS OF THE CORNEA
    - FOREIGN BODY INVOLVING THE OCULAR SURFACE
    - HYPHEMA
    - OPEN GLOBE
    - OPTIC NERVE TRAUMA
    - CHEMICAL INJURIES
    - ORBITAL FRACTURES
    - PENETRATING WOUNDS OF THE ORBIT
    - CHILD ABUSE
    - FIREWORKS-RELATED INJURIES
    - SPORTS-RELATED OCULAR INJURIES AND THEIR PREVENTION
    - HANDHELD LASER RETINAL INJURY
- Part XXVIII. The Ear
  - Chapter 676. General Considerations and Evaluation of the Ear
    - CLINICAL MANIFESTATIONS
    - FACIAL PARALYSIS
    - PHYSICAL EXAMINATION
  - Chapter 677. Hearing Loss
    - INCIDENCE AND PREVALENCE
    - TYPES OF HEARING LOSS
    - ETIOLOGY
    - EFFECTS OF HEARING IMPAIRMENT
    - HEARING SCREENING
    - IDENTIFICATION OF HEARING IMPAIRMENT
    - CLINICAL AUDIOLOGIC EVALUATION
    - TREATMENT
    - GENETIC COUNSELING
    - 677.1. Idiopathic Sudden Sensorineural Hearing Loss
  - Chapter 678. Congenital Malformations of the Ear
    - PINNA MALFORMATIONS
    - CONGENITAL STENOSIS OR ATRESIA OF THE EXTERNAL AUDITORY CANAL
    - CONGENITAL MIDDLE-EAR MALFORMATIONS
    - CONGENITAL INNER EAR MALFORMATIONS
    - CONGENITAL CHOLESTEATOMA
  - Chapter 679. External Otitis (Otitis Externa)
    - ETIOLOGY
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - TREATMENT
    - PREVENTION
    - OTHER DISEASES OF THE EXTERNAL EAR
  - Chapter 680. Otitis Media
    - EPIDEMIOLOGY
    - ETIOLOGY
    - PATHOGENESIS
    - CLINICAL MANIFESTATIONS
    - EXAMINATION OF THE TYMPANIC MEMBRANE
    - PREVENTION
    - IMMUNOPROPHYLAXIS AND VACCINATION STATUS
    - TREATMENT
    - ANTIMICROBIAL PROPHYLAXIS
    - MANAGEMENT OF OTITIS MEDIA WITH EFFUSION
    - INTRACRANIAL COMPLICATIONS
    - POSSIBLE DEVELOPMENTAL SEQUELAE
  - Chapter 681. Acute Mastoiditis
    - ANATOMY
    - EPIDEMIOLOGY
    - MICROBIOLOGY
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS AND IMAGING
    - MANAGEMENT
    - SPECIAL SITUATIONS
  - Chapter 682. The Inner Ear and Diseases of the Bony Labyrinth
    - OTHER DISEASES OF THE INNER EAR
  - Chapter 683. Traumatic Injuries of the Ear and Temporal Bone
    - AURICLE AND EXTERNAL AUDITORY CANAL
    - TYMPANIC MEMBRANE AND MIDDLE EAR
    - TEMPORAL BONE FRACTURES
    - ACOUSTIC TRAUMA
  - Chapter 684. Tumors of the Ear and Temporal Bone
- Part XXIX. The Skin
  - Chapter 685. Morphology of the Skin
    - EPIDERMIS
    - DERMIS
    - SUBCUTANEOUS TISSUE
    - APPENDAGEAL STRUCTURES
  - Chapter 686. Dermatologic Evaluation of the Patient
    - HISTORY AND PHYSICAL EXAMINATION
    - BIOPSY OF SKIN
    - WOOD LAMP
    - POTASSIUM HYDROXIDE PREPARATION
    - TZANCK SMEAR
    - IMMUNOFLUORESCENCE STUDIES
    - 686.1. Cutaneous Manifestations of Systemic Diseases
    - 686.2. Multisystem Medication Reactions
  - Chapter 687. Principles of Dermatologic Therapy
    - WET DRESSINGS
    - BATH OILS, COLLOIDS, AND SOAPS
    - LUBRICANTS
    - SHAMPOOS
    - POWDERS
    - PASTES
    - KERATOLYTIC AGENTS
    - TAR COMPOUNDS
    - ANTIFUNGAL AGENTS
    - TOPICAL ANTIBIOTICS
    - TOPICAL CORTICOSTEROIDS
    - TOPICAL NONSTEROIDAL ANTIINFLAMMATORY AGENTS
    - SUNSCREENS
    - LASER THERAPY
  - Chapter 688. Dermatologic Diseases of the Neonate
    - SEBACEOUS HYPERPLASIA
    - MILIA
    - SUCKING BLISTERS
    - CUTIS MARMORATA
    - HARLEQUIN COLOR CHANGE
    - NEVUS SIMPLEX (SALMON PATCH)
    - CONGENITAL DERMAL MELANOCYTOSIS (SLATE GRAY NEVUS)
    - ERYTHEMA TOXICUM
    - TRANSIENT NEONATAL PUSTULAR MELANOSIS
    - INFANTILE ACROPUSTULOSIS
    - EOSINOPHILIC PUSTULAR FOLLICULITIS
  - Chapter 689. Cutaneous Defects
    - SKIN DIMPLES
    - REDUNDANT SKIN
    - AMNIOTIC CONSTRICTION BANDS
    - PREAURICULAR SINUSES AND PITS
    - ACCESSORY TRAGI
    - BRANCHIAL CLEFT AND THYROGLOSSAL CYSTS AND SINUSES
    - PILONIDAL SINUS AND ABSCESS
    - SUPERNUMERARY NIPPLES
    - APLASIA CUTIS CONGENITA (CONGENITAL ABSENCE OF SKIN)
    - FOCAL FACIAL DERMAL DYSPLASIAS
    - FOCAL DERMAL HYPOPLASIA (GOLTZ-GORLIN SYNDROME)
    - DYSKERATOSIS CONGENITA (ZINSSER-ENGMAN-COLE SYNDROME)
    - CUTIS VERTICIS GYRATA
  - Chapter 690. Ectodermal Dysplasias
    - HYPOHIDROTIC ECTODERMAL DYSPLASIA
    - HIDROTIC ECTODERMAL DYSPLASIA (CLOUSTON SYNDROME)
  - Chapter 691. Vascular Anomalies
    - VASCULAR MALFORMATIONS
    - LYMPHATIC MALFORMATIONS
    - ARTERIOVENOUS MALFORMATION
    - KLIPPEL-TRENAUNAY AND PARKES-WEBER SYNDROMES
    - PHAKOMATOSIS PIGMENTOVASCULARIS
    - NEVUS ANEMICUS
    - VASCULAR TUMORS
  - Chapter 692. Cutaneous Nevi
    - ACQUIRED MELANOCYTIC NEVUS
    - ATYPICAL MELANOCYTIC NEVUS
    - CONGENITAL MELANOCYTIC NEVUS
    - MELANOMA
    - HALO NEVUS
    - SPITZ NEVUS (SPINDLE AND EPITHELIOID CELL NEVUS)
    - ZOSTERIFORM LENTIGINOUS NEVUS (AGMINATED LENTIGINES)
    - NEVUS SPILUS (SPECKLED LENTIGINOUS NEVUS)
    - NEVUS OF OTA AND NEVUS OF ITO
    - BLUE NEVI
    - NEVUS DEPIGMENTOSUS (ACHROMIC NEVUS)
    - EPIDERMAL NEVI
    - NEVUS COMEDONICUS
    - CONNECTIVE TISSUE NEVUS
    - SMOOTH MUSCLE HAMARTOMA
  - Chapter 693. Hyperpigmented Lesions
    - DISORDERS OF PIGMENTATION
    - EPHELIDES (FRECKLES)
    - LENTIGINES
    - CAFÉ-AU-LAIT MACULES
    - INCONTINENTIA PIGMENTI (BLOCH-SULZBERGER DISEASE)
    - POSTINFLAMMATORY PIGMENTARY CHANGES
  - Chapter 694. Hypopigmented Lesions
    - ALBINISM
    - MELANOBLAST MIGRATION ABNORMALITIES
  - Chapter 695. Vesiculobullous Disorders
    - 695.1. Erythema Multiforme
    - 695.2. Reactive Infectious Mucocutaneous Eruption
    - 695.3. Stevens-Johnson Syndrome
    - 695.4. Toxic Epidermal Necrolysis
    - 695.5. Mechanobullous Disorders
    - 695.6. Pemphigus
    - 695.7. Dermatitis Herpetiformis
    - 695.8. Linear Immunoglobulin A (IgA) Dermatosis (Chronic Bullous Dermatosis of Childhood)
  - Chapter 696. Eczematous Disorders
    - 696.1. Contact Dermatitis
    - 696.2. Nummular Eczema
    - 696.3. Pityriasis Alba
    - 696.4. Lichen Simplex Chronicus
    - 696.5. Acute Palmoplantar Eczema
    - 696.6. Seborrheic Dermatitis
  - Chapter 697. Photosensitivity
    - ACUTE SUNBURN REACTION
    - PHOTOSENSITIVE REACTIONS
    - PORPHYRIAS
    - COLLOID MILIUM
    - HYDROA VACCINIFORME
    - SOLAR URTICARIA
    - POLYMORPHOUS LIGHT ERUPTION
    - ACTINIC PRURIGO
    - COCKAYNE SYNDROME
    - XERODERMA PIGMENTOSUM
    - ROTHMUND-THOMSON SYNDROME
    - BLOOM SYNDROME
    - HARTNUP DISEASE
  - Chapter 698. Diseases of the Epidermis
    - 698.1. Psoriasis
    - 698.2. Pityriasis Lichenoides
    - 698.3. Keratosis Pilaris
    - 698.4. Lichen Spinulosus
    - 698.5. Pityriasis Rosea
    - 698.6. Pityriasis Rubra Pilaris
    - 698.7. Darier Disease (Keratosis Follicularis)
    - 698.8. Lichen Nitidus
    - 698.9. Lichen Striatus
    - 698.10. Lichen Planus
    - 698.11. Porokeratosis
    - 698.12. Gianotti-Crosti Syndrome (Papular Acrodermatitis)
    - 698.13. Acanthosis Nigricans
  - Chapter 699. Disorders of Keratinization
    - DISORDERS OF CORNIFICATION
    - COLLODION BABY
    - NONSYNDROMIC ICHTHYOSES
    - AUTOSOMAL RECESSIVE CONGENITAL ICHTHYOSES
    - KERATINOPATHIC ICHTHYOSES
    - OTHER NONSYNDROMIC ICHTHYOSES
    - SYNDROMIC ICHTHYOSES
    - OTHER SYNDROMES WITH ICHTHYOSIS
  - Chapter 700. Diseases of the Dermis
    - KELOID
    - 700.1. Mast Cell Activation Syndrome
  - Chapter 701. Diseases of Subcutaneous Tissue
    - CORTICOSTEROID-INDUCED ATROPHY
    - Raynaud Phenomenon
    - 701.1. Panniculitis and Erythema Nodosum
    - 701.2. Lipodystrophy
  - Chapter 702. Disorders of the Sweat Glands
    - ANHIDROSIS
    - HYPERHIDROSIS
    - MILIARIA
    - BROMHIDROSIS
    - HIDRADENITIS SUPPURATIVA
    - FOX-FORDYCE DISEASE
  - Chapter 703. Disorders of Hair
    - HYPERTRICHOSIS
    - HYPOTRICHOSIS AND ALOPECIA
    - TRAUMATIC ALOPECIA (TRACTION ALOPECIA, HAIR PULLING, TRICHOTILLOMANIA)
    - ALOPECIA AREATA
    - ACQUIRED DIFFUSE HAIR LOSS
    - CONGENITAL DIFFUSE HAIR LOSS
  - Chapter 704. Disorders of the Nails
    - ABNORMALITIES IN NAIL SHAPE OR SIZE
    - CHANGES IN NAIL COLOR
    - NAIL SEPARATION
    - NAIL CHANGES ASSOCIATED WITH SKIN DISEASE
    - TRACHYONYCHIA (20-NAIL DYSTROPHY)
    - NAIL INFECTION
    - PARONYCHIAL INFLAMMATION
    - PARONYCHIAL TUMORS
  - Chapter 705. Disorders of the Mucous Membranes
    - ANGULAR CHEILITIS
    - APHTHOUS STOMATITIS (CANKER SORES)
    - FORDYCE SPOTS
    - EPSTEIN PEARLS (GINGIVAL CYSTS OF THE NEWBORN)
    - MUCOCELE
    - FISSURED TONGUE
    - GEOGRAPHIC TONGUE (BENIGN MIGRATORY GLOSSITIS)
    - BLACK HAIRY TONGUE
    - ORAL HAIRY LEUKOPLAKIA
    - ACUTE NECROTIZING ULCERATIVE GINGIVITIS (VINCENT STOMATITIS, FUSOSPIROCHETAL GINGIVITIS, TRENCH MOUTH)
    - NOMA
    - PTEN HAMARTOMA SYNDROME (COWDEN SYNDROME)
  - Chapter 706. Cutaneous Bacterial Infections
    - 706.1. Impetigo
    - 706.2. Subcutaneous Tissue Infections
    - 706.3. Staphylococcal Scalded Skin Syndrome (Ritter Disease)
    - 706.4. Ecthyma
    - 706.5. Other Cutaneous Bacterial Infections
  - Chapter 707. Cutaneous Fungal Infections
    - TINEA VERSICOLOR
    - DERMATOPHYTOSES
    - CANDIDAL INFECTIONS (CANDIDIASIS AND MONILIASIS)
  - Chapter 708. Cutaneous Viral Infections
    - WART (VERRUCA)
    - MOLLUSCUM CONTAGIOSUM
  - Chapter 709. Arthropod Bites and Infestations
    - 709.1. Arthropod Bites
    - 709.2. Scabies
    - 709.3. Pediculosis
    - 709.4. Seabather’s Eruption
  - Chapter 710. Acne
    - ACNE VULGARIS
    - DRUG-INDUCED ACNE
    - NEONATAL CEPHALIC PUSTULOSIS (FORMERLY NEONATAL ACNE)
    - INFANTILE ACNE
    - MID-CHILDHOOD ACNE
    - ACNE FULMINANS (ACUTE FEBRILE ULCERATIVE ACNE)
  - Chapter 711. Tumors of the Skin
    - INFUNDIBULAR FOLLICULAR CYST
    - MILIUM
    - FIBROFOLLICULOMAS
    - PILAR CYST (TRICHILEMMAL CYST)
    - PILOMATRICOMA (PILOMATRIXOMA)
    - TRICHOEPITHELIOMA
    - ERUPTIVE VELLUS HAIR CYSTS
    - STEATOCYSTOMA MULTIPLEX
    - SYRINGOMA
    - INFANTILE DIGITAL FIBROMA
    - DERMATOFIBROMA
    - JUVENILE XANTHOGRANULOMA
    - LIPOMA
    - BASAL CELL CARCINOMA
    - NEVOID BASAL CELL CARCINOMA SYNDROME (BASAL CELL NEVUS SYNDROME, GORLIN SYNDROME)
    - MELANOMA
    - MUCOSAL NEUROMA SYNDROME (MULTIPLE ENDOCRINE NEOPLASIA TYPE IIB)
  - Chapter 712. Nutritional Dermatoses
    - OVERVIEW
    - ACRODERMATITIS ENTEROPATHICA
    - ESSENTIAL FATTY ACID DEFICIENCY
    - KWASHIORKOR
    - CYSTIC FIBROSIS
    - PELLAGRA
    - SCURVY (VITAMIN C OR ASCORBIC ACID DEFICIENCY)
    - VITAMIN A DEFICIENCY
- Bone and Joint Disorders
  - Section 1. Orthopedic Problems
    - Chapter 713. Orthopedic Growth and Development
      - IN UTERO POSITIONING
      - GROWTH AND DEVELOPMENT
      - CENTERS OF OSSIFICATION
      - GAIT/FUNCTIONAL MATURATION
    - Chapter 714. Orthopedic Evaluation of the Child
      - HISTORY
      - PHYSICAL EXAMINATION
      - NEUROLOGIC EVALUATION
      - LIMPING
      - BACK PAIN
      - RADIOGRAPHIC ASSESSMENT
      - LABORATORY STUDIES
    - Chapter 715. The Foot and Toes
      - 715.1. Metatarsus Adductus
      - 715.2. Calcaneovalgus Feet
      - 715.3. Talipes Equinovarus (Clubfoot)
      - 715.4. Congenital Vertical Talus
      - 715.5. Hypermobile Pes Planus (Flexible Flatfeet)
      - 715.6. Tarsal Coalition
      - 715.7. Cavus Feet
      - 715.8. Osteochondroses/Apophysitis
      - 715.9. Puncture Wounds of the Foot
      - 715.10. Toe Deformities
      - 715.11. Painful Foot
      - 715.12. Shoes
    - Chapter 716. Torsional and Angular Deformities of the Limb
      - 716.1. Normal Limb Development
      - 716.2. Limb Evaluation
      - 716.3. Torsional Deformities
      - 716.4. Coronal Plane Deformities
      - 716.5. Congenital Angular Deformities of the Tibia and Fibula
    - Chapter 717. Leg-Length Discrepancy
      - DIAGNOSIS AND CLINICAL FINDINGS
      - RADIOGRAPHIC EVALUATION
      - TREATMENT
    - Chapter 718. The Knee
      - NORMAL DEVELOPMENT OF THE KNEE
      - ANATOMY AND RANGE OF MOTION
      - 718.1. Discoid Lateral Meniscus
      - 718.2. Popliteal Cysts (Baker Cysts)
      - 718.3. Juvenile Osteochondritis Dissecans
      - 718.4. Osgood-Schlatter Disease and Sinding-Larsen-Johansson Syndrome
      - 718.5. Patellofemoral Pain Syndrome
      - 718.6. Patellofemoral Instability
      - 718.7. Anterior Cruciate Ligament Rupture
    - Chapter 719. The Hip
      - GROWTH AND DEVELOPMENT
      - VASCULAR SUPPLY
      - 719.1. Developmental Dysplasia of the Hip
      - 719.2. Transient Monoarticular Synovitis (Toxic Synovitis)
      - 719.3. Legg-Calvé-Perthes Disease
      - 719.4. Slipped Capital Femoral Epiphysis
    - Chapter 720. The Spine
      - NORMAL SPINAL CURVATURES
      - OVERVIEW OF ABNORMAL SPINAL CURVATURES
      - 720.1. Idiopathic Scoliosis
      - 720.2. Congenital Scoliosis
      - 720.3. Neuromuscular Scoliosis, Genetic Syndromes, and Compensatory Scoliosis
      - 720.4. Kyphosis
      - 720.5. Back Pain in Children
      - 720.6. Spondylolysis and Spondylolisthesis
      - 720.7. Spine Infection
      - 720.8. Intervertebral Disk Herniation/Slipped Vertebral Apophysis
      - 720.9. Tumors
    - Chapter 721. The Neck
      - 721.1. Torticollis
      - 721.2. Klippel-Feil Syndrome
      - 721.3. Cervical Anomalies and Instabilities
    - Chapter 722. The Upper Limb
      - SHOULDER
      - ELBOW
      - WRIST
      - HAND
    - Chapter 723. Arthrogryposis
      - ETIOLOGY
      - CLASSIFICATION
      - MANAGEMENT OF ORTHOPEDIC PROBLEMS OF ARTHROGRYPOSIS
      - FOOT PROBLEMS
      - KNEE PROBLEMS
      - HIP PROBLEMS
      - UPPER EXTREMITY PROBLEMS
    - Chapter 724. Common Fractures
      - 724.1. Unique Characteristics of Pediatric Fractures
      - 724.2. Pediatric Fracture Patterns
      - 724.3. Upper Extremity Fractures
      - 724.4. Lower Extremity Fractures
      - 724.5. Operative Treatment of Fractures
      - 724.6. Complications of Fractures in Children
    - Chapter 725. Osteomyelitis
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - RADIOGRAPHIC EVALUATION
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
    - Chapter 726. Septic Arthritis
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - DIFFERENTIAL DIAGNOSIS
      - TREATMENT
      - PROGNOSIS
  - Section 2. Sports Medicine
    - Chapter 727. Prevention of Injuries
      - PREPARTICIPATION SPORTS EXAMINATION
    - Chapter 728. Management of Musculoskeletal Injury
      - MECHANISM OF INJURY
      - 728.1. Growth Plate Injuries
      - 728.2. Shoulder Injuries
      - 728.3. Elbow Injuries
      - 728.4. Low Back Injuries
      - 728.5. Hip and Pelvis Injuries
      - 728.6. Knee Injuries
      - 728.7. Lower Leg Exertional Pain: Shin Splints, Stress Fractures, and Chronic Compartment Syndrome
      - 728.8. Ankle Injuries
      - 728.9. Foot Injuries
    - Chapter 729. Sports-Related Traumatic Brain Injury (Concussion)
      - DEFINITION/TERMINOLOGY
      - EPIDEMIOLOGOY
      - PATHOPHYSIOLOGY
      - SIGNS AND SYMPTOMS
      - INITIAL ASSESSMENT AND TOOLS
      - MANAGEMENT
      - COMPLICATIONS/LONG-TERM EFFECTS
      - PREVENTION
    - Chapter 730. Cervical Spine Injuries
      - SOFT TISSUE INJURY
      - SPEAR TACKLER’S SPINE
      - CERVICAL FRACTURES
      - STINGERS (BURNERS)
      - BURNING HANDS SYNDROME
      - TRANSIENT QUADRIPARESIS
      - CONGENITAL SPINAL STENOSIS
      - SPINAL CORD INJURY
    - Chapter 731. Heat Injuries
    - Chapter 732. Nutrition and Endocrine Conditions in Athletes
    - Chapter 733. Performance-Enhancing Aids
    - Chapter 734. Specific Sports and Associated Injuries
      - SPORTS PARTICIPATION, EARLY SPECIALIZATION, INJURY RISK, AND BURNOUT
      - FOOTBALL
      - BASEBALL/SOFTBALL
      - BASKETBALL/VOLLEYBALL
      - TENNIS
      - LACROSSE
      - SWIMMING/DIVING
      - SOCCER
      - ICE HOCKEY
      - FIELD HOCKEY
      - SKIING AND SNOWBOARDING
      - SKATEBOARDING
      - CYCLING AND MOTOCROSS
      - WRESTLING
      - RUNNING
      - CHEERLEADING
      - GYMNASTICS
      - DANCE
      - ADAPTIVE SPORTS
  - Section 3. The Skeletal Dysplasias
    - Chapter 735. General Considerations in Skeletal Dysplasias
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - MOLECULAR GENETICS OF SKELETAL DYSPLASIAS
      - PATHOPHYSIOLOGY
      - TREATMENT
    - Chapter 736. Disorders Involving Cartilage Matrix Proteins
      - TYPE 2 COLLAGENOPATHIES
      - KNIEST DYSPLASIA
      - PSEUDOACHONDROPLASIA AND MULTIPLE EPIPHYSEAL DYSPLASIA
      - SCHMID METAPHYSEAL DYSPLASIA
    - Chapter 737. Disorders Involving Transmembrane Receptors
      - FGFR3 CHONDRODYSPLASIA GROUP
      - JANSEN METAPHYSEAL DYSPLASIA
    - Chapter 738. Disorders Involving Ion Transporters
      - AUTOSOMAL RECESSIVE MULTIPLE EPIPHYSEAL DYSPLASIA
    - Chapter 739. Disorders Involving Transcription Factors
      - CAMPOMELIC DYSPLASIA
      - CLEIDOCRANIAL DYSPLASIA
      - SHOX GENE-RELATED CONDITIONS
      - NAIL-PATELLA SYNDROME
    - Chapter 740. Osteopetrosis and Other Disorders Involving Defective Bone Resorption
      - OSTEOPETROSIS
      - CLINICAL MANIFESTATIONS
      - TREATMENT
      - PYCNODYSOSTOSIS AND DYSOSTEOSCLEROSIS
    - Chapter 741. Other Inherited Disorders of Skeletal Development
      - ELLIS-VAN CREVELD SYNDROME
      - ASPHYXIATING THORACIC DYSTROPHY
      - SHORT-RIB POLYDACTYLY SYNDROMES
      - CARTILAGE-HAIR HYPOPLASIA-ANAUXETIC SPECTRUM DISORDERS
      - TRPV4-SPECTRUM DISORDERS
      - METATROPIC DYSPLASIA
      - SPONDYLOMETAPHYSEAL DYSPLASIA, KOZLOWSKI TYPE
      - DISORDERS INVOLVING FILAMINS
      - JUVENILE OSTEOCHONDROSES
      - CAFFEY DISEASE (INFANTILE CORTICAL HYPEROSTOSIS)
      - FIBRODYSPLASIA OSSIFICANS PROGRESSIVA
    - Chapter 742. Osteogenesis Imperfecta
      - ETIOLOGY
      - EPIDEMIOLOGY
      - PATHOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - LABORATORY FINDINGS
      - COMPLICATIONS
      - TREATMENT
      - PROGNOSIS
      - GENETIC COUNSELING
  - Section 4. Connective Tissue Disorders
    - Chapter 743. Marfan Syndrome
      - EPIDEMIOLOGY
      - PATHOGENESIS
      - CLINICAL MANIFESTATIONS
      - DIAGNOSIS
      - DIFFERENTIAL DIAGNOSIS
      - LABORATORY FINDINGS
      - MANAGEMENT
      - CURRENT THERAPIES
      - PROGNOSIS
      - GENETIC COUNSELING
    - Chapter 744. Ehlers-Danlos Syndrome
      - CLASSIFICATION OF THE SIX MOST COMMON SUBTYPES OF EHLERS-DANLOS SYNDROME
      - DIFFERENTIAL DIAGNOSIS
      - GENERAL APPROACH TO MANAGEMENT
    - Chapter 745. Cutis Laxa
      - CLINICAL MANIFESTATIONS
      - HISTOLOGY
      - TREATMENT
  - Section 5. Metabolic Bone Disease
    - Chapter 746. Bone Structure, Growth, and Hormonal Regulation
    - Chapter 747. Hypophosphatasia
    - Chapter 748. Hyperphosphatasia
    - Chapter 749. Osteoporosis
- Part XXXI. Rehabilitation Medicine
  - Chapter 750. Rehabilitation for Traumatic Brain Injury
    - PATHOPHYSIOLOGY
    - SEVERITY
    - MEDICAL COMPLICATIONS
    - OUTCOME ASSOCIATED WITH SEVERE TRAUMATIC BRAIN INJURY
  - Chapter 751. Spinal Cord Injury and Autonomic Dysreflexia Management
    - CLINICAL MANIFESTATIONS
    - PROGNOSIS
  - Chapter 752. Spasticity
    - SYSTEMIC MEDICATIONS
    - INJECTION MANAGEMENT
    - SURGICAL MANAGEMENT
  - Chapter 753. Birth Brachial Plexus Palsy
    - PHYSICAL EXAMINATION
    - EVALUATION
    - TREATMENT
  - Chapter 754. Meningomyelocele (Spina Bifida)
    - ETIOLOGY
    - PREVENTION
    - PRENATAL SCREENING
    - CLINICAL IMPLICATIONS
    - ADOLESCENCE AND TRANSITION TO ADULTHOOD
  - Chapter 755. Upper and Lower Extremity Assistive Devices
    - ORTHOSES
    - PROSTHESES
    - ASSISTIVE MOBILITY DEVICES
    - WHEELCHAIR
    - ROBOTIC DEVICES
  - Chapter 756. Health and Wellness for Children with Disabilities
    - DISABILITY
- Part XXXII. Environmental Health
  - Chapter 757. Overview of Environmental Health and Children
    - GLOBAL CLIMATE CHANGE
    - LOCALIZED ENVIRONMENTAL HAZARDS
    - TOXINS VERSUS TOXICANTS
    - MYCOTOXINS
    - FOOD-BORNE DISEASES CAUSED BY ENVIRONMENTAL EXPOSURES
  - Chapter 758. Biologic Effects of Ionizing Radiation on Children
    - DIAGNOSTIC IMAGING, RADIATION THERAPY
    - BIOLOGIC EFFECTS OF RADIATION
    - RADIATION EXPOSURE IN DIAGNOSTIC IMAGING OF CHILDREN
    - DECREASING UNNECESSARY DIAGNOSTIC RADIATION IN CHILDREN WHILE STILL OBTAINING DIAGNOSTIC IMAGES
    - RADIATION THERAPY: ACUTE AND LATE EFFECTS
    - WHOLE BODY IRRADIATION
    - INTERNAL CONTAMINATION
    - EXTERNAL CONTAMINATION
  - Chapter 759. Chemical Pollutants
    - SYNTHETIC CHEMICALS AND HUMAN HEALTH
    - 759.1. Tobacco
    - 759.2. Marijuana Smoke Exposure
  - Chapter 760. Heavy Metal Intoxication
    - ARSENIC
    - MERCURY
    - TREATMENT OF ARSENIC AND MERCURY INTOXICATION
  - Chapter 761. Lead Poisoning
    - PUBLIC HEALTH HISTORY
    - SOURCES OF EXPOSURE
    - METABOLISM
    - CLINICAL EFFECTS
    - CLINICAL SYMPTOMS
    - DIAGNOSIS
    - TREATMENT
  - Chapter 762. Nonbacterial Food Poisoning
    - 762.1. Mushroom Poisoning
    - 762.2. Solanine Poisoning
    - 762.3. Seafood Poisoning
    - 762.4. Melamine Poisoning
  - Chapter 763. Biological and Chemical Terrorism
    - ETIOLOGY
    - EPIDEMIOLOGY AND PEDIATRIC-SPECIFIC CONCERNS
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - PREVENTION
    - TREATMENT
  - Chapter 764. Mass Psychogenic Illness
    - CLINICAL FEATURES AND DIAGNOSIS
    - TREATMENT STRATEGIES
  - Chapter 765. Animal and Human Bites
    - EPIDEMIOLOGY
    - CLINICAL MANIFESTATIONS
    - DIAGNOSIS
    - COMPLICATIONS
    - TREATMENT
    - PREVENTION
  - Chapter 766. Rat Bite Fever
    - ETIOLOGY
    - CLINICAL COURSE
    - DIAGNOSIS
    - TREATMENT
  - Chapter 767. Mpox (Monkeypox)
    - CLINICAL COURSE
    - PREVENTION AND TREATMENT
  - Chapter 768. Envenomations
    - GENERAL APPROACH TO THE ENVENOMATED CHILD
    - SNAKE BITES
    - SPIDER BITES
    - SCORPION STINGS
    - HYMENOPTERA STINGS
    - MARINE ENVENOMATION
- Part XXXIII. Laboratory Medicine (available in digital format only)
  - Chapter 769. Laboratory Testing in Infants and Children
    - COMMON CHALLENGES IN PEDIATRIC LABORATORY MEDICINE
    - ACCURACY AND PRECISION OF LABORATORY TESTS
    - SENSITIVITY, ACCURACY, AND ANALYTIC TESTING
    - PREDICTIVE VALUE OF LABORATORY TESTS
    - NEONATAL SCREENING TESTS
    - TESTING IN REFINING A DIFFERENTIAL DIAGNOSIS
  - Chapter 770. Reference Intervals for Laboratory Tests and Procedures
Index

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Þú getur flakkað milli síðna og kafla eins og þér hentar best og farið beint í ákveðna kafla úr efnisyfirlitinu. Í leitinni finnur þú orð, kafla eða síður í einum smelli.

Glósur og yfirstrikanir
Þú getur auðkennt textabrot með mismunandi litum og skrifað glósur að vild í rafbókina. Þú getur jafnvel séð glósur og yfirstrikanir hjá bekkjarsystkinum og kennara ef þeir leyfa það. Allt á einum stað.

Hvað viltu sjá? / Þú ræður hvernig síðan lítur út
Þú lagar síðuna að þínum þörfum. Stækkaðu eða minnkaðu myndir og texta með multi-level zoom til að sjá síðuna eins og þér hentar best í þínu námi.

Fleiri góðir kostir
- Þú getur prentað síður úr bókinni (innan þeirra marka sem útgefandinn setur)
- Möguleiki á tengingu við annað stafrænt og gagnvirkt efni, svo sem myndbönd eða spurningar úr efninu
- Auðvelt að afrita og líma efni/texta fyrir t.d. heimaverkefni eða ritgerðir
- Styður tækni sem hjálpar nemendum með sjón- eða heyrnarskerðingu

Lesa meira Minnka

Eiginleikar

Gerð : 208
Höfundur : 6474
Útgáfuár : 2019
Leyfi : 380

10.690 kr.

Nelson Textbook of Pediatrics, 2-Volume

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Nelson Textbook of Pediatrics, 2-Volume

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UM RAFBÆKUR Á HEIMKAUP.IS

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