Medical Pharmacology at a Glance
Höfundur: Michael J. Neal
3.990 kr.
Lýsing:
The internationally best-selling Medical Pharmacology at a Glance is the ideal companion for all medical and healthcare students, providing a visual overview of pharmacology, and describing the basic principles of drug action, interaction, absorption, and excretion. Clear and accessible chapters organised around common diseases and conditions facilitate efficient clinical learning, and include references to drug classes and side effects, disease pathophysiology, prescribing guidelines, and more.
Now in its ninth edition, this leading guide has been thoroughly updated to reflect current guidelines and drug information. This edition features new and revised illustrations, additional pedagogical tools, and enhanced online content. Widely recognised as both the best introduction to medical pharmacology and the perfect revision tool for USMLE and pharmacology exams, this invaluable guide: Covers a wide range of drugs used to treat conditions such as hypertension, anaemias, cancer, and affective disorders Explains drug mechanisms and the principles of drug action Discusses practical topics including drug misuse, drug indications, and side effects Includes a companion website featuring online cases, flashcards, and a list of core drugs.
Annað
- Höfundur: Michael J. Neal
- Útgáfa:9
- Útgáfudagur: 2020-01-10
- Hægt að prenta út 10 bls.
- Hægt að afrita 2 bls.
- Format:ePub
- ISBN 13: 9781119548096
- Print ISBN: 9781119548010
- ISBN 10: 1119548098
Efnisyfirlit
- Cover
- Preface
- Acknowledgements
- Further reading
- List of abbreviations
- Core drugs
- About the companion website
- 1 Introduction
- Receptors
- Transport systems
- Enzymes
- Second messengers
- G‐proteins
- 2 Drug–receptor interactions
- Binding of drugs to receptors
- Antagonists
- Receptor reserve
- Partial agonists
- Intrinsic efficacy
- Bioassay
- Binding assays
- Localization of receptors
- Tachyphylaxis, desensitization, tolerance and drug resistance
- 3 Drug absorption, distribution and excretion
- Routes of administration
- Distribution and excretion
- Excretion
- 4 Drug metabolism
- Drugs
- Liver
- Phase I reactions
- Phase II reactions
- Factors affecting drug metabolism
- Metabolism and drug toxicity
- 5 Local anaesthetics
- Na+ channels
- Action potential
- Mechanism of local anaesthetics
- Chemistry
- Unwanted effects
- Methods of administration
- 6 Drugs acting at the neuromuscular junction
- Presynaptic agents
- Competitive neuromuscular blocking drugs
- Depolarizing neuromuscular blocking drugs
- 7 Autonomic nervous system
- Effects of sympathetic stimulation
- Acetylcholine
- 8 Autonomic drugs acting at cholinergic synapses
- Cholinomimetics
- Muscarinic antagonists (antimuscarinics)
- 9 Drugs acting on the sympathetic system
- Sympathomimetics
- Adrenoceptor antagonists
- 10 Ocular pharmacology
- Glaucoma
- Mydriatics
- 11 Asthma, hay fever and anaphylaxis
- Mediators
- Bronchodilators
- Cromoglicate
- Corticosteroids
- Acute severe asthma
- Antihistamines
- 12 Drugs acting on the gastrointestinal tract I
- Acid secretion
- Protective factors
- Ulcer healing drugs
- Antacids
- 13 Drugs acting on the gastrointestinal tract II
- Motility stimulants
- Laxatives
- Antidiarrhoeal drugs
- Drugs used in inflammatory bowel disease
- Drugs used to dissolve gallstones
- Pancreatic supplements
- 14 Drugs acting on the kidney
- Thiazides
- Loop diuretics
- Potassium‐sparing diuretics
- 15 Drugs used in hypertension
- Thiazide and other diuretics
- β‐adrenoceptor antagonists
- Vasodilator drugs
- Centrally acting drugs
- Acute severe hypertension
- 16 Drugs used in angina
- Nitrates
- β‐Adrenoceptor antagonists
- Calcium‐channel blockers
- Revascularization
- 17 Antiarrhythmic drugs
- Cardiac action potential
- Pacemaker cells
- Drugs used in supraventricular arrhythmias
- Drugs effective in supraventricular and ventricular arrhythmias
- Drugs used in ventricular arrhythmias
- Alternatives to drugs
- 18 Drugs used in heart failure
- ACE inhibitors and ARBs
- β‐blockers
- Inotropic drugs
- Sympathomimetic agents
- 19 Drugs used to affect blood coagulation
- Anticoagulants
- Antiplatelet drugs
- Fibrinolytic drugs (thrombolytics)
- 20 Lipid‐lowering drugs
- Lipoproteins
- Hyperlipidaemias
- Atherosclerosis
- Drug combinations
- 21 Agents used in anaemias
- Iron
- Iron preparations
- Vitamin B12
- Folic acid
- Erythropoietin
- 22 Central transmitter substances
- Amino acids
- Monoamines
- Other transmitters/modulaters
- 23 General anaesthetics
- Reticular activating system (RAS)
- Mechanism of action of anaesthetics
- Premedication
- Intravenous agents
- Inhalation agents
- 24 Anxiolytics and hypnotics
- GABA receptors
- Barbiturate receptor
- Benzodiazepines
- Antidepressants
- Drugs acting at serotonergic (5HT) receptors
- 25 Antiepileptic drugs
- Causes of epilepsy
- Mechanisms of action of anticonvulsants
- Drugs used in partial and generalized tonic–clonic (grand mal) seizures
- Drugs used to treat absences (petit mal)
- Drugs effective in tonic–clonic (grand mal) and absence (petit mal) seizures
- Drug withdrawal
- Pregnancy
- 26 Drugs used in Parkinson’s disease
- Aetiology
- Dopaminergic drugs
- Dopamine agonists
- Drugs causing dopamine release
- Antimuscarinics
- 27 Antipsychotic drugs (neuroleptics)
- Dopamine receptors
- Chemical classification
- Depot preparations
- 28 Drugs used in affective disorders: antidepressants
- Monoamine theory of depression
- Mechanism of action of antidepressants
- Drugs that inhibit amine uptake
- Receptor blockers
- Monoamine oxidase inhibitors
- Mechanism of action
- 29 Opioid analgesics
- Strong opioid analgesics
- Weak opioid analgesics
- 30 Drugs used in nausea and vertigo (antiemetics)
- Drug‐induced vomiting
- Motion sickness
- Vestibular disease
- Pregnancy
- 31 Drug misuse and dependence
- Central stimulants
- Opioids
- Hallucinogens (psychedelics)
- General depressants
- Tobacco
- 32 Non‐steroidal anti‐inflammatory drugs (NSAIDs)
- Mechanisms of action
- Adverse effects
- Other NSAIDs
- Gout
- 33 Corticosteroids
- Glucocorticoids
- Mineralocorticoids
- 34 Sex hormones and drugs
- Infertility
- Testosterone
- Oestrogens
- Progestogens
- Progestogens are used for hormonal contraception and for producing long‐term ovarian suppression for other purposes (e.g. dysmenorrhoea, endometriosis, hirsutism and bleeding disorders) when oestrogens are contraindicated.
- Oral contraceptives
- 35 Thyroid and antithyroid drugs
- Hyperthyroidism (thyrotoxicosis)
- Antithyroid drugs
- Hypothyroidism
- Replacement therapy
- 36 Antidiabetic agents
- Insulin release
- Insulin preparations
- Oral antidiabetic drugs
- 37 Antibacterial drugs that inhibit nucleic acid synthesis
- Selective toxicity
- Sulphonamides
- Quinolones
- 5‐Nitroimidazoles
- 38 Antibacterial drugs that inhibit cell wall synthesis
- Penicillins
- Cephalosporins
- Other β‐lactam antibiotics
- Vancomycin
- 39 Antibacterial drugs that inhibit protein synthesis
- Aminoglycosides
- Macrolides
- Tetracyclines
- Chloramphenicol
- 40 Antifungal drugs
- Fungal infections
- Polyenes
- Flucytosine
- Imidazoles
- Triazoles
- Echinocandins
- 41 Antiviral drugs
- Drugs that prevent the virus entering or leaving the host cells
- Drugs that inhibit viral DNA polymerase
- Drugs that inhibit viral reverse transcriptase
- Protease inhibitors
- Integrase inhibitors
- Immunomodulators
- 42 Drugs acting on parasites I
- Nematodes (roundworms)
- Trematodes (flukes)
- Cestodes (tapeworms)
- Anthelmintics
- 43 Drugs acting on parasites II
- Blood schizonticides (rapid‐acting)
- Blood schizonticides (slow‐acting)
- Tissue schizonticide
- Other protozoal diseases
- 44 Drugs used in cancer
- Alkylating agents
- Cytotoxic antibiotics
- Vinca alkaloids and taxanes
- Antimetabolites
- Monoclonal antibodies
- Hormones and hormone antagonists
- 45 Immunosuppressants and antirheumatoid drugs
- Corticosteroids
- Antiproliferative drugs
- Calcineurin inhibitors
- Monoclonal antibodies
- Disease‐modifying antirheumatoid drugs (DMARDs)
- Anticytokine drugs
- 46 Poisoning
- Reduction of absorption
- Enhancement of elimination
- Aspirin
- Paracetamol
- Opioids
- Tricyclic antidepressants
- Heavy metals
- 47 Adverse drug reactions
- Drug interactions
- Drug allergy
- Teratogenesis
- Carcinogenesis
- Case studies and questions
- Answers
- Index
- End User License Agreement
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