Introduction to the Pharmaceutical Sciences: An Integrated Approach
Námskeið LYF110G Inngangur að lyfjafræði. - Höfundar: Nita K Pandit PhD, Robert P Soltis PhD
10.690 kr.
Námskeið
- LYF110G Inngangur að lyfjafræði.
Ensk lýsing:
This unique textbook provides an introductory, yet comprehensive overview of the pharmaceutical sciences. It is the first text of its kind to pursue an interdisciplinary approach. Readers are introduced to basic concepts related to the specific disciplines in the pharmaceutical sciences, including pharmacology, pharmaceutics, pharmacokinetics, and medicinal chemistry. In an easy-to-read writing style, the book provides readers with up-to-date information on pharmacogenomics and includes comprehensive coverage of industrial drug development and regulatory approval processes.
Lýsing:
This unique textbook provides an introductory, yet comprehensive overview of the pharmaceutical sciences. It is the first text of its kind to pursue an interdisciplinary approach. Readers are introduced to basic concepts related to the specific disciplines in the pharmaceutical sciences, including pharmacology, pharmaceutics, pharmacokinetics, and medicinal chemistry. In an easy-to-read writing style, the book provides readers with up-to-date information on pharmacogenomics and includes comprehensive coverage of industrial drug development and regulatory approval processes.
Annað
- Höfundar: Nita K Pandit PhD, Robert P Soltis PhD
- Útgáfa:2
- Útgáfudagur: 10/2011
- Hægt að prenta út 2 bls.
- Hægt að afrita 2 bls.
- Format:Page Fidelity
- ISBN 13: 9781451167504
- Print ISBN: 9781609130015
- ISBN 10: 1451167504
Efnisyfirlit
- Introduction to the Pharmaceutical Sciences: An Integrated Approach, Second Edition
- Copyright
- Preface
- Acknowledgments
- Contents
- Additional Resources
- Chapter 1: Introduction
- What Is a Drug?
- How Do Drugs Work?
- How Are Drugs Designed?
- How Are Drugs Administered?
- How Are Drugs Transported in the Body?
- How Are Drugs Used Clinically in Patients?
- How Do Genetic Factors Affect Drug Therapy?
- How Are New Drugs Developed and Approved for Marketing?
- Concluding Remarks
- Part I: Drug Chemistry
- Chapter 2: Drugs and Their Targets
- Targets and Biological Activity
- Binding to the Target
- Physicochemical Properties of Drugs
- Structure–Activity Relationships
- Key Concepts
- Review Questions
- Practice Problems
- Additional Readings
- Chapter 3: Ionization of Drugs
- Electrolytes and Nonelectrolytes
- Importance of Ionization of Weak Electrolytes
- Water as a Solvent
- Strong Acids and Bases
- Weak Acids and Bases
- Salts of Weak Acids and Bases
- Ionization and pH
- Ionization in Unbuffered Solutions
- Compounds with Multiple Ionizable Groups
- Key Concepts
- Review Questions
- Practice Problems
- Additional Readings
- Chapter 4: Solubility and Lipophilicity
- Solubility Principles
- The Solvent
- Water Solubility
- Lipophilicity
- Amphiphilicity
- Key Concepts
- Review Questions
- Practice Problems
- Additional Readings
- Chapter 2: Drugs and Their Targets
- Chapter 5: Transport Across Biological Barriers
- Transport Across the Cell Membrane
- Transport Across a Tissue
- Multiple Transport Pathways
- Key Concepts
- Review Questions
- Additional Readings
- Chapter 6: Drug Absorption
- Systemic Administration
- Systemic Absorption of Macromolecular Drugs
- Local Administration
- Key Concepts
- Review Questions
- Additional Readings
- Chapter 7: Drug Delivery Systems
- Dosage Forms
- Drug Release and Dissolution
- Approaches to Drug Delivery
- Drug Stability
- Delivery of Macromolecular Drugs
- Key Concepts
- Review Questions
- Additional Readings
- Chapter 8: Drug Distribution
- The Circulatory System
- Drug Distribution Processes
- Volume of Distribution
- Key Concepts
- Review Questions
- Practice Problems
- Additional Readings
- Chapter 9: Drug Excretion
- Excretion by the Kidneys
- Excretion by the Liver
- Excretion by Other Organs
- Key Concepts
- Review Questions
- Practice Problems
- Additional Readings
- Chapter 10: Drug Metabolism
- Excretion or Metabolism?
- Drugs, Metabolites, and Enzymes
- Kinetics of Drug Metabolism
- Types of Drug Metabolism Reactions
- Sites of Metabolism
- Total Body Clearance
- Factors Altering Drug Metabolism
- Key Concepts
- Review Questions
- Practice Problems
- Additional Readings
- Chapter 11: Pharmacokinetic Concepts
- Pharmacokinetics and Pharmacodynamics
- Drug Concentrations in Body Fluids
- Plasma Level Curves
- Pharmacokinetic Features of a Plasma Level Curve
- Relationship Between Pharmacokinetics and Pharmacodynamics
- Pharmacological Features of a Plasma Level Curve
- Multiple Dosing
- Key Concepts
- Review Questions
- Practice Problems
- Additional Readings
- Chapter 12: Ligands and Receptors
- The Signaling Process
- Endogenous Ligands
- Specificity of Actions
- Receptors
- Receptor Structure and Classification
- Modulation of Ligand–Receptor Interactions
- Key Concepts
- Review Questions
- Additional Readings
- Chapter 13: Mechanisms of Drug Action
- Theory of Drug Action
- Quantitation of Drug–Receptor Interactions
- Mechanisms of Antagonism
- Stereoselectivity in Drug Action
- Interaction of Drugs with Enzymes
- Nonreceptor-Based Drug Action
- Key Concepts
- Review Questions
- Additional Readings
- Chapter 14: Dose–Response Relationships
- Concentration–Response Relationships
- Dose–Response Relationships
- Dose-Related Selectivity and Toxicity
- Key Concepts
- Review Questions
- Additional Readings
- Chapter 15: Therapeutic Variability
- Types of Therapeutic Variability
- Drug Compliance
- Individualization of Therapy
- Key Concepts
- Review Questions
- Additional Readings
- Chapter 16: Drug Interactions
- Drug–Drug Interactions
- Food–Drug Interactions
- Drug–Herbal Interactions
- Dealing with Interactions
- Key Concepts
- Review Questions
- Additional Readings
- Chapter 17: Pharmacogenomics
- Review of Genetics
- Genetic Variation and Disease
- Genetic Variation and Response to Drugs
- Clinical Applications of Pharmacogenomics
- Proteomics
- Promise of Pharmacogenomics
- Key Concepts
- Review Questions
- Additional Readings
- Chapter 18: Biopharmaceutical Drugs
- Biotechnology and Genetic Engineering
- Advantages of the Biopharmaceutical Approach
- Types of Biopharmaceutical Drugs
- Formulation of Biopharmaceutical Drugs
- Stability of Biopharmaceutical Products
- ADME of Biopharmaceutical Drugs
- Pharmacological Considerations of Biopharmaceutical Drugs
- Opportunities and Limitations of Biopharmaceuticals
- Nucleic Acid-Based Therapeutics
- Gene Therapy
- Key Concepts
- Review Questions
- Additional Readings
- Chapter 19: Drug Discovery and Approval
- The FDA
- New Drug Development
- Generic Drug Development and Approval
- Pharmacogenomics in Drug Development
- Over-the-Counter Drugs
- Key Concepts
- Review Questions
- Additional Readings
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- Gerð : 208
- Höfundur : 6665
- Útgáfuár : 2011
- Leyfi : 379
