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Rang & Dale's Pharmacology E-Book

Vörumerki: Elsevier
Vörunúmer: 9780702074462
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Rang & Dale's Pharmacology E-Book

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Rafbók til eignar. Rafbók til eignar þarf að hlaða niður á þau tæki sem þú vilt nota innan eins árs frá því bókin er keypt. Útgáfa: 9

Efnisyfirlit

  • Cover image
  • Title Page
  • Table of Contents
  • Copyright
  • Rang and Dale's Pharmacology Ninth Edition Preface
  • Acknowledgements
  • Section 1 General principles
    • 1 What is pharmacology?
      • What Is a Drug?
      • Origins and Antecedents
      • Pharmacology in the 20Th and 21St Centuries
      • References and Further Reading
    • 2 How drugs act
      • Introduction
      • Protein Targets for Drug Binding
      • Desensitisation and Tolerance
      • Quantitative Aspects of Drug–Receptor Interactions
      • The Nature of Drug Effects
      • References and Further Reading
    • 3 How drugs act
      • Protein Targets for Drug Action
      • Receptor Proteins
      • Ion Channels as Drug Targets
      • Control of Receptor Expression
      • Receptors and Disease
      • References and Further Reading
    • 4 How drugs act
      • Regulation of Intracellular Calcium
      • Excitation
      • Muscle Contraction
      • Release of Chemical Mediators
      • Epithelial Ion Transport
      • References and Further Reading
    • 5 How drugs act
      • Introduction
      • Protein and Oligonucleotide Biopharmaceuticals
      • Oligonucleotides
      • Gene Therapy
      • Safety and Societal Issues
      • Therapeutic Applications
      • Concluding Remarks
      • References and Further Reading
    • 6 Cell proliferation, apoptosis, repair and regeneration
      • Cell Proliferation
      • Angiogenesis
      • Apoptosis and Cell Removal
      • Pathophysiological Implications
      • Therapeutic Prospects
      • References and Further Reading
    • 7 Cellular mechanisms
      • Introduction
      • The Innate Immune Response
      • The Adaptive Immune Response
      • Systemic Responses in Inflammation
      • References and Further Reading
    • 8 Method and measurement in pharmacology
      • Bioassay
      • Animal Models of Disease
      • Pharmacological Studies in Humans
      • Clinical Trials
      • References and Further Reading
    • 9 Absorption and distribution of drugs
      • Introduction
      • Physical Processes Underlying Drug Disposition
      • Drug Absorption and Routes of Administration
      • Distribution of Drugs in the Body
      • Special Drug Delivery Systems
      • References and Further Reading
    • 10 Drug metabolism and elimination
      • Introduction
      • Drug and Metabolite Excretion
      • References and Further Reading
    • 11 Pharmacokinetics
      • Introduction: Definition and Uses of Pharmacokinetics
      • Drug Elimination Expressed as Clearance
      • Single-Compartment Model
      • More Complicated Kinetic Models
      • Population Pharmacokinetics
      • Limitations of Pharmacokinetics
      • References and Further Reading
    • 12 Individual variation, pharmacogenomics and personalised medicine
      • Introduction
      • Epidemiological Factors and Inter-Individual Variation of Drug Response
      • Genetic Variation in Drug Responsiveness
      • Therapeutic Drugs and Clinically Available Pharmacogenomic Tests
      • Conclusions
      • References and Further Reading
  • Section 2 Chemical mediators
    • 13 Chemical mediators and the autonomic nervous system
      • Historical Aspects
      • The Autonomic Nervous System
      • Some General Principles of Chemical Transmission
      • Basic Steps in Neurochemical Transmission: Sites of Drug Action
      • References and Further Reading
    • 14 Cholinergic transmission
      • Muscarinic and Nicotinic Actions of Acetylcholine
      • Acetylcholine Receptors
      • Nicotinic Receptors
      • Physiology of Cholinergic Transmission
      • Effects of Drugs on Cholinergic Transmission
      • References and Further Reading
    • 15 Noradrenergic transmission
      • Catecholamines
      • Classification of Adrenoceptors
      • Physiology of Noradrenergic Transmission
      • Drugs Acting on Noradrenergic Transmission
      • References and Further Reading
    • 16 5-Hydroxytryptamine and the pharmacology of migraine
      • 5-Hydroxytryptamine
      • Migraine and Other Clinical Conditions in Which 5-HT Plays a Role
      • References and Further Reading
    • 17 Purines
      • Introduction
      • Purinergic Receptors
      • Adenosine as a Mediator
      • ADP as a Mediator
      • ATP as a Mediator
      • Future Prospects
      • References and Further Reading
    • 18 Local hormones 1
      • Introduction
      • What Is a ‘Mediator’?
      • Histamine
      • Eicosanoids
      • Leukotrienes
      • Other Important Fatty Acid Derivatives
      • Platelet-Activating Factor
      • Concluding Remarks
      • References and Further Reading
    • 19 Local hormones 2
      • Introduction
      • General Principles of Protein and Peptide Pharmacology
      • Biosynthesis and Regulation of Peptides
      • Bradykinin
      • Neuropeptides
      • Cytokines
      • Proteins and Peptides That Down-Regulate Inflammation
      • Concluding Remarks
      • References and Further Reading
    • 20 Cannabinoids
      • Plant-Derived Cannabinoids and Their Pharmacological Effects
      • Cannabinoid Receptors
      • Endocannabinoids
      • Synthetic Cannabinoids
      • Clinical Applications
      • References and Further Reading
    • 21 Nitric oxide and related mediators
      • Introduction
      • Biosynthesis of Nitric Oxide and Its Control
      • Degradation and Carriage of Nitric Oxide
      • Effects of Nitric Oxide
      • Therapeutic Aspects
      • Clinical Conditions in Which Nitric Oxide May Play A Part
      • Related Mediators
      • References and Further Reading
  • Section 3 Drugs affecting major organ systems
    • 22 The heart
      • Introduction
      • Physiology of Cardiac Function
      • Autonomic Control of the Heart
      • Cardiac Natriuretic Peptides
      • Ischaemic Heart Disease
      • Drugs That Affect Cardiac Function
      • References and Further Reading
    • 23 The vascular system
      • Introduction
      • Vascular Structure and Function
      • Control of Vascular Smooth Muscle Tone
      • Vasoactive Drugs
      • Clinical Uses of Vasoactive Drugs
      • References and Further Reading
    • 24 Atherosclerosis and lipoprotein metabolism
      • Introduction
      • Atherogenesis
      • Lipoprotein Transport
      • Prevention of Atheromatous Disease
      • Lipid-Lowering Drugs
      • References and Further Reading
    • 25 Haemostasis and thrombosis
      • Introduction
      • Blood Coagulation
      • Drugs That Act on the Coagulation Cascade
      • Platelet Adhesion and Activation
      • Fibrinolysis (Thrombolysis)
      • References and Further Reading
    • 26 Haematopoietic system and treatment of anaemia
      • Introduction
      • The Haematopoietic System
      • Types of Anaemia
      • Haematinic Agents
      • Haematopoietic Growth Factors
      • Haemolytic Anaemia
      • References and Further Reading
    • 27 Anti-inflammatory and immunosuppressant drugs
      • Introduction
      • Cyclo-Oxygenase Inhibitors
      • Antirheumatoid Drugs
      • Anticytokine Drugs and Other Biopharmaceuticals
      • Drugs Used in Gout
      • Antagonists of Histamine
      • Possible Future Developments IN ANTIINFLAMMATORY THERAPY
      • References and Further Reading
    • 28 Skin
      • Introduction
      • Structure of Skin
      • Common Diseases of the Skin
      • Drugs Acting on Skin
      • Principal Drugs Used in Skin Disorders
      • Agents Acting by Other Mechanisms
      • Concluding Remarks
      • References and Further Reading
    • 29 Respiratory system
      • The Physiology of Respiration
      • Pulmonary Disease and Its Treatment
      • References and Further Reading
    • 30 The kidney and urinary system
      • Introduction
      • Outline of Renal Function
      • The Structure and Function of the Nephron
      • Drugs Acting on the Kidney
      • Drugs That Alter the pH of the Urine
      • Drugs That Alter the Excretion of Organic Molecules
      • Drugs Used in Renal Failure
      • Drugs Used in Urinary Tract Disorders
      • References and Further Reading
    • 31 The gastrointestinal tract
      • The Innervation and Hormones of the Gastrointestinal Tract
      • Gastric Secretion
      • Vomiting
      • The Motility of the GI Tract
      • Drugs for Chronic Bowel Disease
      • Drugs Affecting the Biliary System
      • Future Directions
      • References and Further Reading
    • 32 The control of blood glucose and drug treatment of diabetes mellitus
      • Introduction
      • Control of Blood Glucose
      • Pancreatic Islet Hormones
      • Diabetes Mellitus
      • References and Further Reading
    • 33 Obesity
      • Introduction
      • Obesity as a Health Problem
      • Homeostatic Mechanisms Controlling Energy Balance
      • The Pathophysiology of Human Obesity
      • Pharmacological Approaches to the Problem of Obesity
      • New Approaches to Obesity Therapy
      • References and Further Reading
    • 34 The pituitary and the adrenal cortex
      • The Pituitary Gland
      • The Adrenal Cortex
      • New Directions in Glucocorticoid Therapy
      • References and Further Reading
    • 35 The thyroid
      • Synthesis, Storage and Secretion of Thyroid Hormones
      • Regulation of Thyroid Function
      • Actions of the Thyroid Hormones
      • Transport and Metabolism of Thyroid Hormones
      • Abnormalities of Thyroid Function
      • Drugs Used in Diseases of the Thyroid
      • References and Further Reading
    • 36 The reproductive system
      • Introduction
      • Endocrine Control of Reproduction
      • Drugs Affecting Reproductive Function
      • Drugs Used for Contraception
      • The Uterus
      • Erectile Dysfunction
      • References and Further Reading
    • 37 Bone metabolism
      • Introduction
      • Bone Structure and Composition
      • Bone Remodelling
      • Disorders of Bone
      • Drugs Used in Bone Disorders
      • Potential New Therapies
      • References and Further Reading
  • Section 4 Nervous system
    • 38 Chemical transmission and drug action in the central nervous system
      • Introduction
      • Chemical Signalling in the Nervous System
      • Targets for Drug Action
      • Drug Action in the Central Nervous System
      • The Classification of Psychotropic Drugs
      • References and Further Reading
    • 39 Amino acid transmitters
      • Excitatory Amino Acids
      • Glutamate
      • ?-Aminobutyric Acid (GABA)
      • Glycine
      • Concluding Remarks
      • References and further reading
    • 40 Other transmitters and modulators
      • Introduction
      • Noradrenaline
      • Dopamine
      • 5-Hydroxytryptamine
      • Acetylcholine
      • Purines
      • Histamine
      • Other CNS Mediators
      • A Final Message
      • References and Further Reading
    • 41 Neurodegenerative diseases
      • Protein Misfolding and Aggregation in Chronic Neurodegenerative Diseases
      • Mechanisms of Neuronal Death
      • Ischaemic Brain Damage
      • Alzheimer's Disease
      • Parkinson's Disease
      • Huntington's Disease
      • Amyotrophic Lateral Sclerosis
      • Spinal Muscular Atrophy
      • Multiple Sclerosis
      • References and Further Reading
    • 42 General anaesthetic agents
      • Introduction
      • Mechanism of Action of Anaesthetic Drugs
      • Intravenous Anaesthetic Agents
      • Inhalation Anaesthetics
      • Individual Inhalation Anaesthetics
      • Balanced Anaesthesia
      • References and Further Reading
    • 43 Analgesic drugs
      • Neural Mechanisms of Pain
      • Analgesic Drugs
      • References and further reading
    • 44 Local anaesthetics and other drugs affecting sodium channels
      • Local Anaesthetics
      • Other Drugs That Affect Sodium Channels
      • References and Further Reading
    • 45 Anxiolytic and hypnotic drugs
      • The Nature of Anxiety and Its Treatment
      • Measurement of Anxiolytic Activity
      • Drugs Used to Treat Anxiety
      • Delayed Anxiolytic Effect of SSRIs and Buspirone
      • Drugs Used to Treat Insomnia (Hypnotic Drugs)
      • References and Further Reading
    • 46 Antiepileptic drugs
      • Introduction
      • The Nature of Epilepsy
      • Antiepileptic Drugs
      • Muscle Spasm and Muscle Relaxants
      • References and Further Reading
    • 47 Antipsychotic drugs
      • Introduction
      • The Nature of Schizophrenia
      • Antipsychotic Drugs
      • Future Developments
      • References and Further Reading
    • 48 Antidepressant drugs
      • The Nature of Depression
      • Theories of Depression
      • Antidepressant Drugs
      • Clinical Effectiveness of Antidepressant Treatments
      • Future Antidepressant Drugs
      • Brain Stimulation Therapies
      • Drug Treatment of Bipolar Disorder
      • References and Further Reading
    • 49 Psychoactive drugs
      • Introduction
      • Psychomotor Stimulants
      • Cognition-Enhancing Drugs
      • Psychedelic Drugs
      • Ketamine and Related Drugs
      • Depressants
      • Tolerance and Dependence
      • Synthetic Cannabinoids
      • References and Further Reading
    • 50 Drug abuse and dependence
      • Drug Use and Abuse
      • References and Further Reading
  • Section 5 Drugs used for the treatment of infections and cancer
    • 51 Basic principles of antimicrobial chemotherapy
      • Background
      • The Molecular Basis of Chemotherapy
      • Resistance to Antibacterial Drugs
      • Current Status of Antibiotic Resistance in Bacteria
      • References and Further Reading
    • 52 Antibacterial drugs
      • Introduction
      • Antibacterial Agents That Interfere With Folate Synthesis or Action
      • ß-Lactam Antibiotics and Other Agents That Interfere With Bacterial Wall or Membrane Synthesis
      • Antimicrobial Agents Affecting Bacterial Protein Synthesis
      • Antimicrobial Agents Affecting Topoisomerase
      • Miscellaneous Antibacterial Agents
      • Antimycobacterial Agents
      • Possible New Antibacterial Drugs
      • References and Further Reading
    • 53 Antiviral drugs
      • Background Information About Viruses
      • The Host–Virus Interaction
      • HIV and AIDS
      • Antiviral Drugs
      • Combination Therapy for HIV
      • Prospects for New Antiviral Drugs
      • References and further reading
    • 54 Antifungal drugs
      • Fungi and Fungal Infections
      • Drugs Used to Treat Fungal Infections
      • Future Developments
      • References and Further Reading
    • 55 Antiprotozoal drugs
      • Background
      • Host–Parasite Interactions
      • Malaria and Antimalarial Drugs
      • Amoebiasis and Amoebicidal Drugs
      • Trypanosomiasis and Trypanocidal Drugs
      • Other Protozoal Infections and Drugs Used to Treat Them
      • Future Developments
      • References and Further Reading
    • 56 Antihelminthic drugs
      • Helminth Infections
      • Antihelminthic Drugs
      • Resistance to Antihelminthic Drugs
      • Vaccines and Other Novel Approaches
      • References and Further Reading
    • 57 Anticancer drugs
      • Introduction
      • The Pathogenesis of Cancer
      • General Principles of Cytotoxic Anticancer Drugs
      • Anticancer Drugs
      • Future Developments
      • References and Further Reading
  • Section 6 Special topics
    • 58 Harmful effects of drugs
      • Introduction
      • Classification of Adverse Drug Reactions
      • Drug Toxicity
      • Immunological Reactions to Drugs
      • References and further reading
    • 59 Lifestyle and drugs in sport
      • What Are Lifestyle Drugs?
      • Classification of Lifestyle Drugs
      • Drugs and Sex
      • Drugs in Sport
      • Conclusion
      • References and Further Reading
    • 60 Drug discovery and development
      • The Stages of a Project
      • Biopharmaceuticals
      • Commercial Aspects
      • Future Prospects
      • A Final Word
      • References and Further Reading
  • Index

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Vörumerki: Elsevier
Vörunúmer: 9780702074462
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