Pathology at a Glance
Námskeið
- LEI502G Líffærameinafræði - sjúkdómar.
Lýsing:
Following the familiar, easy-to-use at a Glance format and in full-colour, Pathology at a Glance is an accessible introduction and revision text for medical students. Reflecting changes to the curriculum content and assessment methods employed by medical schools, this new edition provides a user-friendly overview of pathology to encapsulate all that the student needs to know. Pathology at a Glance , Second Edition: Addresses the key principles of pathology that are central to medicine Contains full-colour artwork throughout, making the subject easy to understand Presents schematic diagrams on the left page and concise explanations on the right Is divided into three sections, covering general and systematic pathology and clinical case examples Contains self-assessment material, including 10 structured case study questions Covers general pathology mechanisms and the clinical pathology of body systems Provides key information on the epidemiology, pathogenesis and clinical features of the major diseases Revision of many chapters, particularly gynaecological pathology, acute cardiac syndromes, paediatric tumours and haematopathology This book is an invaluable resource for all medical students, of equal benefit for those starting their study of pathology or approaching finals; for junior doctors approaching their membership exams and anybody who needs a handy reference.
Annað
- Höfundar: Barry Newell, Asma Z. Faruqi, Caroline Finlayson
- Útgáfa:2
- Útgáfudagur: 2021-12-29
- Hægt að prenta út 10 bls.
- Hægt að afrita 2 bls.
- Format:ePub
- ISBN 13: 9781119472469
- Print ISBN: 9781119472452
- ISBN 10: 1119472466
Efnisyfirlit
- Cover
- Title Page
- Copyright
- Dedication
- Preface
- Acknowledgements
- Abbreviations
- General pathology
- Introduction
- 1 The normal human cell
- Nucleus
- Cytosol
- Cytoskeleton
- Organelles
- 2 Fluid dynamics
- Electrolytes
- Blood and blood filtration
- Lymphatic system
- Transudates
- Exudate
- 1 The normal human cell
- Introduction
- Tissue damage
- 3 Tissue types and the effect of tissue damage
- Normal tissue types
- Proliferative and regenerative capacity
- Tissue necrosis
- Types of infarction
- 4 Cell death
- Apoptosis
- Necrosis
- Autophagy
- Free radicals
- 5 Harmful agents in the environment
- Environmental pollution
- Physical agents
- Chemical agents
- Water
- Infectious agents
- 6 The effects of tobacco, alcohol and other drugs
- Tobacco
- Alcohol
- General observations regarding common therapeutic and addictive drugs
- 7 Nutritional disorders
- Nutritional deficiency
- Obesity
- 3 Tissue types and the effect of tissue damage
- 8 The body's natural defences
- Epithelial barriers
- Types of immunity
- Cells involved in the innate immune response
- Protein mediators
- Key events in the innate immune response
- Adaptive immunity
- 9 B cells and immunoglobulins
- Immunoglobulin structure and subtypes
- Immunoglobulin variability
- Limitation of the B‐cell response
- 10 T cells and the TCR
- T cell receptor
- T helper cells (Th cells)
- Cytotoxic T cells (CTL)
- Memory T cells (Tm)
- Limiting the T‐cell response
- 11 The major histocompatibility complex
- MHC class I molecules
- MHC class II molecules
- Tissue transplantation
- Bone marrow transplantation
- 12 Primary and secondary lymphoid organs and the monocyte–macrophage (reticuloendothelial) system
- Monocyte–macrophage system (also called the reticuloendothelial system)
- Bone marrow
- Lymphoid organs
- 13 Acute inflammation
- Systemic effects
- 14 Chronic inflammation
- Special types of chronic inflammation
- 15 Wound healing and repair
- Wound healing
- Wound healing at other sites
- Complications of healing
- 16 Infection and immunodeficiency
- Infective agents
- Immunodeficiency
- 17 Shock
- Definition
- Causes
- Clinical consequences
- Acute tubular necrosis (ATN)
- Adult respiratory distress syndrome (ARDS, ‘shock lung’)
- 18 Tolerance and autoimmune disease
- B‐cell tolerance
- T‐cell tolerance
- Autoimmune diseases
- 19 Hypersensitivity reactions
- Type I hypersensitivity (allergic and anaphylactic responses)
- Type II hypersensitivity
- Type III hypersensitivity
- Type IV hypersensitivity (delayed hypersensitivity)
- 20 Overview of inflammation and immunity
- Immune system
- Summary
- 21 Cell division
- Mitosis
- Meiosis
- Terminology
- 22 Genetic disease
- Chromosomal disorders
- Autosomal disorders
- X‐linked disorders
- Mitochondrial disorders
- 23 Disordered cell growth
- Developmental disorders
- Non‐tumorous growth disorders
- 24 Basic concepts in neoplasia
- Nomenclature
- Benign tumours
- Malignant tumours
- 25 Tumorigenesis and oncogenesis
- DNA protection
- Control of cell division
- Theories of oncogenesis
- Target cells
- Causes of mutation
- 26 Oncogenes and tumour suppressor genes
- Oncogenes
- Tumour suppressor genes
- Telomerase
- Role of genetic testing in tumour investigation and treatment
- 27 Common carcinoma histological subtypes
- Specific carcinomas
- Example generic descriptions
- 28 Tumour prognosis and treatment
- Prognosis
- Treatment
- Cure and tumour‐free survival
- Prevention
- 29 Basic techniques in histopathology
- Dissection
- Tissue processing
- The request form
- 30 Cytopathology
- Gynaecological cytology (the cervical smear)
- Diagnostic cytopathology
- Utility of FNA
- 31 Molecular pathology
- K‐Ras
- EGFR
- B‐Raf
- c‐Kit
- PD‐L1
- Multisystems disease
- 32 Sarcoidosis and syphilis
- Sarcoidosis
- Syphilis
- 33 Wilson's disease and haemochromatosis
- Wilson's disease
- Haemochromatosis
- 34 Systemic vasculitis
- Common pathology
- Wegener's granulomatosis
- Microscopic polyarteritis
- Polyarteritis nodosa
- Churg–Strauss syndrome
- Giant cell arteritis
- Takayasu's arteritis
- 32 Sarcoidosis and syphilis
- 35 Normal blood vessels and types of aneurysm
- Endothelium
- Vascular smooth muscle cells
- Aneurysms
- 36 Congenital heart disease
- Acyanotic congenital heart disease
- Cyanotic congenital heart disease
- 37 Systemic hypertension
- Control of blood pressure
- Causes
- Complications of hypertension
- Accelerated hypertension
- 38 Atherosclerosis
- Definition
- Aetiology
- Precursor lesion
- Pathogenesis
- Complications
- Treatment
- 39 Coronary heart disease
- Definition
- Angina pectoris
- Myocardial infarction
- 40 Thrombosis
- Normal haemostasis
- Pathologically significant locations of thrombus
- Venous thrombosis
- Thrombolysis
- Sequelae following thrombosis
- 41 Embolism and disseminated intravascular coagulation
- Embolism
- Disseminated intravascular coagulation
- 42 Cardiac valvular disease
- Aortic and pulmonary valves
- Mitral and tricuspid valves
- Causes of cardiac valvular disease
- 43 Myocardial and pericardial disease
- Hypertrophic cardiomyopathy
- Dilated cardiomyopathy
- Restrictive cardiomyopathy
- Arrhythmogenic right ventricular dysplasia
- Myocarditis
- Pericarditis
- Constrictive pericarditis
- Tamponade
- 44 Pulmonary vascular disorders
- Pulmonary embolism
- Pulmonary infarction
- Pulmonary hypertension
- Clinical correlations
- 45 Pneumonia
- Definition
- Epidemiology
- Microbiology
- Pathology
- Clinical correlations
- 46 Bronchiectasis
- Definition
- Causes
- Epidemiology
- Pathology
- Clinical correlations
- 47 Tuberculosis
- Sequelae following TB infection
- Clinical diagnosis
- Treatment
- Prevention
- HIV and TB are synergistic
- 48 Chronic obstructive pulmonary disease
- Definition
- Causes
- Epidemiology
- Pathology
- Clinical correlations and complications
- α1‐Antitrypsin deficiency
- 49 Fibrosing alveolitis
- Fibrosing alveolitis
- Extrinsic allergic alveolitis
- 50 Primary lung carcinoma
- Definition
- Epidemiology
- Causes
- Histological types
- Macroscopic features
- Spread
- Staging
- Clinical correlations
- Prognosis
- 51 Other tumours of the lung and pleura
- Malignant mesothelioma
- Secondary tumours of the lung and pleura
- Benign lung tumours
- Other malignant lung tumours
- 52 Malabsorption
- Malabsorption
- Diarrhoea
- Coeliac disease
- 53 Peptic ulceration and Helicobacter pylori
- Helicobacter pylori
- NSAIDs
- Duodenal peptic ulcer
- Gastric peptic ulcer
- Pathological features of peptic ulcers
- 54 Oesophageal disease
- Gastro‐oesophageal reflux disease
- Oesophageal cancer
- 55 Tumours of the stomach and small intestine
- Gastric cancer
- Other tumours
- 56 Mechanical disease of the gastrointestinal tract
- Diverticular disease
- Volvulus
- Intussusception
- Other causes of bowel infarction
- 57 Inflammatory bowel disease: ulcerative colitis and Crohn's disease
- Epidemiology
- Aetiology and pathogenesis
- Clinical presentation
- Clinical investigations
- Gross features (see diagram)
- Microscopic features (see diagram)
- Clinical course
- Sequelae
- 58 Colorectal polyps, colorectal cancer and anal carcinoma
- Colorectal polyps
- Colorectal carcinoma
- Anal cancer
- 59 Normal liver and the effects of liver damage
- Normal liver
- Acinar zone 3 is an ‘at risk’ region
- Cirrhotic patients have altered blood flow
- Liver regeneration
- Hepatic failure
- 60 Jaundice, gallstones and carcinoma of the gallbladder
- Causes of jaundice
- Gallstones
- Cholecystitis
- Adenocarcinoma of the gallbladder
- 61 Fatty liver disease: alcoholic and non‐alcoholic
- Alcoholic liver disease
- Non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitis
- 62 Autoimmune liver disease: AIH, PBC, PSC
- Autoimmune hepatitis (AIH)
- Idiosyncratic (i.e. unpredictable) drug reactions can mimic AIH
- Primary biliary cholangitis
- Primary sclerosing cholangitis
- Secondary biliary sclerosis
- 63 Viral hepatitis
- Hepatitis A
- Hepatitis B
- Hepatitis C
- Hepatitis D
- Hepatitis E
- Hepatitis G
- Pathology
- 64 Cirrhosis
- Definition
- Causes
- Pathology
- Clinical correlations
- 65 Acute and chronic pancreatitis
- Acute haemorrhagic pancreatitis
- Chronic pancreatitis
- 66 Tumours of the liver, biliary tree and pancreas
- Secondary liver tumours
- Benign primary liver tumours
- Malignant primary liver tumours
- Biliary tree tumours
- Ampullary adenocarcinoma
- Primary pancreatic tumours
- 67 Congenital and inherited abnormalities of the kidney and urinary tract
- Inherited abnormalities
- Congenital and developmental abnormalities
- 68 The nephron and renal aspects of hypertension
- Vascular diseases of the kidney
- 69 Glomerulonephritis
- Nephritic syndrome
- Nephrotic syndrome
- Secondary glomerulonephritis
- 70 Important types of glomerulonephritis
- Proliferative disease
- Non‐proliferative disease
- 71 Tubulointerstitial diseases
- Acute tubular necrosis
- Tubulointerstitial nephritis
- Acute and chronic pyelonephritis
- Renal calculi
- 72 Renal neoplasms
- Renal cell carcinoma
- Urothelial carcinoma
- Other tumours
- 73 Bladder tumours
- Definition
- Epidemiology
- Risk factors
- Pathology
- Pattern of spread
- Staging
- Prognosis
- 74 Testicular cancer
- Definition
- Epidemiology
- Risk factors
- Pathology
- Pattern of spread
- Prognosis
- 75 Prostatic disease
- Prostate cancer
- Benign prostatic hyperplasia
- 76 Vulval and vaginal pathology
- Vulval carcinoma
- Other vulval neoplasms
- Non‐neoplastic vulvovaginal conditions
- 77 Cervical cancer
- Epidemiology
- Aetiology and risk factors
- Precursor lesions
- Cervical screening
- HPV vaccination
- Pathology
- Spread
- Staging
- Treatment
- 78 Benign uterine conditions
- Endometrial polyps
- Adenomyosis/adenomyoma
- Endometriosis
- Infections
- Benign neoplasms
- 79 Uterine malignancies
- Epithelial malignancies
- Mesenchymal malignancies
- Future developments
- 80 Ovarian neoplasia: part one
- Benign neoplasms
- Borderline ovarian neoplasms (atypically proliferating neoplasms)
- Ovarian carcinoma
- 81 Ovarian neoplasia: part two
- Germ cell tumours
- Sex cord stromal tumours
- Small cell carcinoma hypercalcaemic type
- Paraneoplastic syndromes
- Metastatic disease
- 82 Obstetric pathology
- Gestational trophoblastic neoplasia
- Ectopic pregnancy
- Placenta creta
- 83 Paediatric tumours
- Wilms' tumour (nephroblastoma)
- Neuroblastoma
- Retinoblastoma
- 84 Cerebrovascular accidents
- Definition
- Epidemiology
- Types
- Risk factors
- Pathophysiology
- Gross features
- Microscopic features
- Clinical correlations
- 85 Cerebrovascular accident syndromes
- 86 Raised intracranial pressure
- Definition
- Causes
- Pathophysiology
- 87 Traumatic injury and intracranial haemorrhage
- Extradural haemorrhage
- Chronic subdural haemorrhage
- Acute subdural haemorrhage
- Subarachnoid haemorrhage
- Cerebral contusions
- Diffuse axonal injury
- 88 Central nervous system tumours
- Primary tumours
- Secondary tumours
- 89 Infections of the nervous system
- Bacterial meningitis
- Other forms of meningitis
- Encephalitis
- Brain abscess
- Other infections
- 90 Movement disorders
- General principles
- Motor neurone disease
- Parkinson's disease
- Huntington's chorea
- 91 Acquired disorders of myelination
- Multiple sclerosis
- Other forms of CNS demyelination
- Guillain–Barré syndrome
- Chronic inflammatory demyelinating polyradiculoneuropathy
- 92 Dementia
- Alzheimer's disease
- Pick's disease
- Creutzfeldt–Jakob disease
- Vascular dementia
- General considerations
- 93 Pituitary pathology
- Syndrome of inappropriate ADH secretion
- Diabetes insipidus
- Hypopituitarism
- Pituitary tumours
- Craniopharyngioma
- 94 Non‐neoplastic pathology of the thyroid
- Hyperthyroidism, e.g. Graves' disease
- Hypothyroidism, e.g. Hashimoto's thyroiditis
- De Quervain's thyroiditis
- Riedel's thyroiditis
- Goitre
- 95 Thyroid neoplasms
- Follicular adenoma
- Follicular carcinoma
- Papillary carcinoma
- Medullary carcinoma
- Anaplastic carcinoma
- General staging
- 96 Parathyroid gland pathology
- Hyperparathryoidism
- Hypoparathyroidism
- Pseudohypoparathyroidism
- Pseudopseudohypoparathyroidism
- Multiple endocrine neoplasia
- 97 Adrenal pathology
- Phaeochromocytoma
- Addison's disease
- Secondary hypoadrenalism
- Cushing's syndrome
- Mineralocorticoid excess
- 98 Diabetes mellitus
- Epidemiology
- Aetiology and pathogenesis
- Clinical features
- Clinical diagnosis
- Gross features
- Microscopic features
- Complications
- 99 Head and neck pathology
- Cholesteatoma
- Salivary glands
- Nasal polyps
- Tumours
- 100 Assorted haematological conditions
- Bone marrow failure
- 101 Leukaemia
- Acute leukaemia
- Chronic leukaemia
- 102 Lymphoma
- Hodgkin lymphoma
- Non‐Hodgkin lymphoma
- Staging
- Prognosis
- 103 Myeloma
- Definition
- Epidemiology
- Pathology
- Clinical diagnosis
- Complications
- Prognosis
- 104 Myeloproliferative disorders
- Molecular aspects
- Diagnosis
- Polycythaemia vera
- Essential thrombocythaemia
- Primary myelofibrosis
- Secondary myelofibrosis
- 105 Muscle disorders
- Myasthenia gravis
- Eaton–Lambert syndrome
- Polymyositis
- Myotonic dystrophy
- Duchenne muscular dystrophy
- 106 Arthritis
- Rheumatoid arthritis
- Osteoarthritis
- Gout
- Other forms of arthritis
- 107 Miscellaneous non‐neoplastic osteoarticular pathology
- Osteoporosis
- Osteomalacia
- Paget's disease
- Osteomyelitis
- Septic arthritis
- 108 Bone tumours
- Secondary tumours
- Osteosarcoma
- Ewing's sarcoma
- Chondrosarcoma
- Giant cell tumour
- Osteoid osteoma
- 109 Inflammatory dermatoses
- Terminology
- Basic categories
- Clinical correlations
- 110 Benign skin tumours
- Fibroepithelial polyp
- Seborrhoeic keratosis
- Epidermoid cyst
- Pilar cyst
- Dermatofibroma
- Melanocytic naevi
- 111 Malignant skin tumours
- Basal cell carcinoma
- Squamous cell carcinoma
- Melanoma
- Actinic keratosis and Bowen's disease
- 112 Benign breast disease
- Fibroadenoma
- Hamartoma
- Fibrocystic/benign breast change
- Papilloma
- Epithelial hyperplasia
- Others
- 113 Breast carcinoma
- Definition
- Epidemiology
- Risk factors
- Pathology
- Pattern of spread
- Staging
- Prognosis
- Case 1: Acute collapse with chest pain
- Case 2: Recent weakness and malaise
- Case 3: At the breast clinic
- Case 4: Recent‐onset neurological signs
- Case 5: Shortness of breath
- Case 6: Facial rash and joint problems
- Case 7: Long‐standing upper GI tract problems
- Case 8: The wisdom of the ancients
- Case 9: A small boy with big problems
- Case 10: A pregnant woman with viral hepatitis
- Case 1
- Case 2
- Case 3
- Case 4
- Case 5
- Case 6
- Case 7
- Case 8
- Case 9
- Case 10
- Biochemistry
- Blood gases (room air)
- Haematology
- Hormones
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