Mechanosensitivity and Mechanotransduction
Lýsing:
This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton.
Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart.
In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling.
Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field.
Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment.
Annað
- Höfundar: Andre Kamkin, Irina Kiseleva
- Útgáfa:1
- Útgáfudagur: 2010-11-18
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- Format:ePub
- ISBN 13: 9789048198818
- Print ISBN: 9789048198801
- ISBN 10: 904819881X
Efnisyfirlit
- Cover
- Frontmatter
- 1. The Role of Cytoskeleton in Mechanosensitivity and Mechanotransduction
- 1. Integrin-Mediated Mechanotransduction in Vascular Smooth Muscle Cells
- 2. The Role of the Actin Cytoskeleton in Mechanosensation
- 3. Effect of Cytoskeleton on the Mechanosensitivity of Genes in Osteoblasts
- 4. Involvement of the Cytoskeletal Elements in Articular Cartilage Mechanotransduction
- 2. Molecular Mechanisms of Mechanotransduction and Ion Channels Modulation
- 5. The Role of Nitric Oxide in the Regulation of Mechanically Gated Channels in the Heart
- 6. Role of Signaling Pathways in the Myocardial Response to Biomechanical Stress and in Mechanotransduction in the Heart
- 7. Atomistic Molecular Simulation of Gating Modifier Venom Peptides – Two Binding Modes and Effects of Lipid Structure
- 3. Mechanosensitivity and Mechanotransduction in Vascular Cells
- 8. Cellular and Molecular Effects of Mechanical Stretch on Vascular Cells
- 9. Role of Proteoglycans in Vascular Mechanotransduction
- 4. Mechanotransduction in the Lung
- 10. Control of TRPV4 and Its Effect on the Lung
- 11. The Role of Protein-protein Interactions in Mechanotransduction: Implications in Ventilator Induced Lung Injury
- 5. Mechanosensing and Mechanotransduction in Bone and Joint Tissues
- 12. Cellular Mechanisms of Mechanotransduction in Bone
- 13. The Mechanosensitivity of Cells in Joint Tissues: Role in the Pathogenesis of Joint Diseases
- 6. Mechanotransduction of Sensor System
- 14. Primary Cilia are Mechanosensory Organelles in Vestibular Tissues
- 7. Mechanosensitivity and Mechanotransduction in Blood Cells
- 15. Mechanosensitive K+ Channels in Mouse B Lymphocytes: PLC-Mediated Release of TREK-2 from Inhibition by PIP2
- Backmatter
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- Gerð : 208
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- Útgáfuár : 2010
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