Efnisyfirlit

• Instructions for online access
• Cover image
• Title page
• Table of Contents
• Copyright
• Foreword to the Tenth Edition
• Preface to the Tenth Edition
• Online Clinical Overviews
• Online Special Topics
• Online Clinical Cases
• List of Contributors
• International Advisory Board
• Acknowledgements for the Tenth Edition
• 1. Diagnosis: The art of being a doctor
  • Core Skills and Knowledge
  • Diagnosis in the Clinical Consultation
  • The medical consultation
  • Clinical diagnostic reasoning
  • Communicating a diagnosis
  • Diagnosis, artificial intelligence and the future of medicine
• 2. Human genetics
  • Core Skills and Knowledge
  • Clinical skills for genetic medicine
  • Introduction
  • Clinical genetics
  • The cellular basis of genetics
  • Genetic disorders
  • Techniques for studying the genetic code
  • Genomic medicine
  • The genetic basis of cancer
• 3. Immunity
  • Core Skills and Knowledge
  • Introducing the tissues, cells and molecules of the immune system
  • Innate immune system
  • Adaptive immune system
  • Cell migration
  • HLA molecules and antigen presentation
  • The immune system in concert
  • Laboratory investigations of the immune system
  • Clinical immunodeficiency
  • Allergic disease (immediate hypersensitivity)
  • Autoimmune disease
  • Organ rejection in clinical transplantation
  • Immune-based therapies
• 4. Evidence-based practice
  • Core Skills and Knowledge
  • Introduction
  • Asking Answerable Questions
  • Searching for the Evidence
  • Appraising the Evidence
  • Applying the Evidence
  • Section 1: Asking Answerable Questions and Searching for the Evidence
  • Section 2: Critical Appraisal
  • Section 3: Interpreting Odds Ratios, Confidence Intervals and P-Values
  • Section 4: Multiple Choice Questions
• 5. Ethical practice and clinical communication
  • Core Skills and Knowledge
  • Ethics and the law
  • Communication in medicine
• 6. Malignant disease
  • Core Skills and Knowledge
  • Clinical skills for malignant disease
  • Introduction
  • The biology of cancer
  • Aetiology and epidemiology
  • Screening and investigations
  • Principles of cancer treatment
  • Acute oncology
  • Common solid tumour treatment
  • Lung cancer
  • Breast cancer
  • Upper gastrointestinal cancers
  • Lower gastrointestinal cancers
  • Hepatobiliary and pancreatic cancers
  • Urological cancers
  • Gynaecological cancers
  • Brain tumours
  • Head and neck cancer
  • Metastatic cancer of unknown primary
• 7. Palliative care and symptom control
  • Core Skills and Knowledge
  • Introduction and General Aspects
  • Symptom Control
  • Palliative Care in Non-Malignant Disease
  • Care of the Dying
• 8. Sepsis and the treatment of bacterial infection
  • Core Skills and Knowledge
  • clinical skills for infection and sepsis
  • Introduction
  • Pathophysiology
  • recognition of sepsis
  • Management of Sepsis
  • Antimicrobial Stewardship
  • Antibiotic Therapies
• 9. Water balance, fluids and electrolytes
  • Core skills and knowledge
  • Clinical skills for water balance, fluids and electrolytes
  • Water and Electrolytes
  • Disorders of sodium concentration
  • Disorders of potassium concentration
  • Disorders of magnesium concentration
  • Disorders of phosphate concentration
  • Acid–Base Disorders
• 10. Critical care medicine
  • Core Skills and Knowledge
  • Introduction
  • Clinical approach to the critically ill patient
  • Applied cardiorespiratory physiology
  • Disturbances of acid–base balance
  • Shock, sepsis and acute disturbances of haemodynamic function
  • Respiratory failure
  • Acute respiratory distress syndrome
  • Acute Kidney injury
  • Neurocritical care
  • Outcomes
• 11. Surgery
  • Core Skills and Knowledge
  • Clinical skills for surgery
  • Introduction
  • The pathophysiology of surgery
  • Management of the perioperative patient
  • The patient journey in surgery
  • Surgical Ethics, Consent and the Law
• 12. Prescribing, therapeutics and toxicology
  • Core Skills and Knowledge
  • Prescribing
  • Why do patients need drugs?
  • The choice of drug
  • The dose
  • Prescribing in special populations
  • Monitoring drug therapy
  • Adverse drug reactions
  • Drug interactions
  • Information sources
  • Poisoning
  • Clinical approach to the poisoned patient
  • Principles of management of poisoning
  • Specific poisons
  • Poisons in the natural world: additional online content
• 13. Global health
  • Core Skills and Knowledge
  • Introduction
  • Millennium and Sustainable Development Goals
  • Global Burden of Disease
  • Poverty
  • Water and Sanitation
  • Organizations and the global health agenda
  • Education
  • Maternal and Child Health
  • Mental health
  • Accidents and Trauma
  • Conflict and Catastrophe
  • Economics and Politics in Global Health
  • Social Determinants of Health
  • Human rights and the value of engagement in global health
• 14. Public health
  • Core Skills and Knowledge
  • Introduction
  • Key Concepts in Public Health
  • Pillars of Public Health
• 15. Geriatric medicine, frailty and multimorbidity
  • Core Skills and Knowledge
  • Introduction
  • Ageing
  • Investigations in Older Adults
  • Taking a History
  • Multimorbidity, Sarcopenia and Frailty
  • Comprehensive Geriatric Assessment
  • Advance Care Planning
  • The Most Common Issues in Older People
  • Ageing Well and Advantages of Ageing
• 16. Haematology
  • Core Skills and Knowledge
  • Clinical skills for haematology
  • Examination
  • Investigations
  • Introduction
  • The red cell
  • Anaemia: an introduction
  • Microcytic anaemia
  • Normocytic anaemia
  • Macrocytic anaemias
  • Anaemia due to marrow failure (aplastic anaemia)
  • Haemolytic anaemias: an introduction
  • Inherited haemolytic anaemia
  • Acquired haemolytic anaemia
  • Polycythaemia
  • The spleen
  • Blood transfusion
  • Blood groups
  • Procedure for blood transfusion in hospitals
  • Complications of blood transfusion
  • Strategies for the avoidance of unnecessary transfusion
  • Blood, blood components and blood products
  • The white cell
  • Haemostasis
  • Vascular disorders
  • Platelet disorders
  • Inherited coagulation disorders
  • Acquired coagulation disorders
• 17. Haematological oncology
  • Core Skills and Knowledge
  • Clinical skills for haematological oncology
  • Introduction
  • Leukaemias
  • Myelodysplasia
  • Clinical features
  • Investigations
  • Management
  • MDS/MPN overlap syndromes
  • Lymphomas
  • Myeloma and other plasma cell disorders
• 18. Rheumatology
  • Core Skills and Knowledge
  • Clinical skills for rheumatology
  • Approach to the patient
  • Anatomy and physiology of the normal joint
  • Investigation of rheumatic disease
  • Clinical conditions in rheumatology
  • Common regional musculoskeletal problems
  • Chronic pain syndromes
  • Analgesic and anti-inflammatory drugs for musculoskeletal problems
  • Disorders of collagen
  • Osteoarthritis
  • Inflammatory Arthritis
  • Rheumatoid arthritis
  • Spondyloarthritis
  • Infections of joints
  • Autoimmune rheumatic diseases
  • Systemic inflammatory vasculitis
  • Arthritis in children
  • Rheumatological problems seen in other diseases
  • Miscellaneous arthropathies
• 19. Bone disease
  • Core Skills and Knowledge
  • Clinical skills for bone disease
  • Anatomy and physiology of bone
  • Investigation of bone and calcium disorders
  • Osteoporosis
  • Osteonecrosis
  • Paget’s disease of bone
  • Rickets and osteomalacia
  • Bone infections
  • Neoplastic disease of bone
  • Scheuermann’s disease
• 20. Infectious disease
  • Core Skills and Knowledge
  • Core content
  • Clinical skills for infectious disease
  • Introduction
  • Clinical approach to the patient with a suspected infection
  • Epidemiology and prevention of infections
  • Principles and mechanisms of infection
  • Viral Infections
  • Virus infections of the skin and mucous membranes
  • Virus infections of the respiratory tract
  • Systemic viral infections
  • Virus infections of the nervous system
  • Virus infections of the gastrointestinal tract
  • Viral hepatitis
  • Viruses and malignant disease
  • Viral haemorrhagic fevers
  • Antiviral drugs
  • Transmissible Spongiform Encephalopathies (Prion Diseases)
  • Bacterial Infections
  • Bacterial infections of the skin and soft tissues
  • Bacterial infections of the respiratory tract
  • Bacterial infections of the gastrointestinal tract
  • Bacterial infections of the cardiovascular system
  • Bacterial infections of the nervous system
  • Bacterial bone and joint infections
  • Bacterial infections of the urinary tract
  • Systemic/multisystem bacterial infections
  • Bacterial infections seen in developing and tropical countries
  • Antibiotic therapies
  • Fungal Infections
  • Systemic fungal infections
  • Subcutaneous fungal infections
  • Superficial fungal infections
  • Antifungal drugs
  • Protozoal Infections
  • Blood and tissue protozoa
  • Gastrointestinal protozoa
  • Helminthic Infections
  • Nematodes
  • Trematodes
  • Cestodes
  • Arthropod Ectoparasites
• 21. Endocrinology
  • Core Skills and Knowledge
  • Clinical skills for endocrinology
  • Introduction
  • The pituitary gland and hypothalamus
  • Hypothalamo–Pituitary–adrenal axis
  • The thyroid axis
  • Hypothalamo–pituitary–gonadal axis
  • Growth and puberty
  • The Thirst Axis
  • Disorders of Calcium Metabolism
  • Hypoglycaemia in the non-diabetic patient
  • Other endocrine disorders
• 22. Dermatology
  • Core Skills and Knowledge
  • Clinical Skills for Dermatology
  • Introduction
  • Skin structure and function
  • Investigation of Skin Disease
  • Principles of Dermatological Therapy
  • Erythroderma and Loss of Skin Function (‘Skin Failure’)
  • Common rashes
  • Skin Infections
  • Human Immunodeficiency Virus and the Skin
  • Skin Signs of Systemic Disease
  • Photosensitivity
  • Blistering and Bullous Skin Disease
  • Skin Tumours
  • Disorders of Pigmentation
  • Nail Disorders
  • Hair Disorders
  • Birth Marks and Neonatal Rashes
  • Drug Eruptions
• 23. Diabetes mellitus
  • Core Skills and Knowledge
  • Clinical skills for diabetes mellitus
  • Introduction
  • Physiology of insulin structure, secretion and action
  • Classification of diabetes
  • Clinical Approach to the Patient With Diabetes
  • Prevention of Type 2 Diabetes
  • Management of diabetes
  • Diabetic metabolic emergencies
  • Complications of diabetes
  • Psychosocial Implications of Diabetes
  • Diabetes in special situations
  • Organization of diabetes care
• 24. Lipid and metabolic disorders
  • Core Skills and Knowledge
  • Introduction
  • History
  • Examination
  • Investigations
  • Disorders of lipid metabolism
  • Inherited metabolic diseases
• 25. Liaison psychiatry
  • Core Skills and Knowledge
  • Introduction
  • Clinical approach to the patient with a psychiatric disorder
  • Classification of psychiatric disorders
  • Aetiology of psychiatric disorders
  • Psychiatric aspects of physical diseases
  • Sick role and illness behaviour
  • Functional somatic syndromes
  • Somatoform disorders
  • Dissociative/conversion disorders
  • Sleep difficulties
  • Mood (affective) disorders
  • Suicide and self-harm
  • Anxiety disorders
  • Alcohol misuse and dependence
  • Drug misuse and dependence
  • Schizophrenia
  • Organic mental disorders
  • Eating disorders
  • Sexual disorders
  • Personality disorders
  • Involuntary Detention
  • Mental Capacity Act
• 26. Neurology
  • Core Skills and Knowledge
  • Clinical skills for neurology
  • Introduction
  • Clinical approach to the patient with neurological disease
  • Functional neuroanatomy
  • Cranial nerves
  • Motor control systems
  • Lower motor neurone lesions
  • Sensory pathways and pain
  • Bladder control and sexual dysfunction
  • Investigation of neurological disease
  • Unconsciousness and coma
  • Stroke
  • Intracranial haemorrhage
  • Headache, migraine and facial pain
  • Epilepsy and loss of consciousness
  • Movement disorders
  • Neuroinflammatory disorders
  • Nervous system infection
  • Hydrocephalus
  • Traumatic brain injury
  • Spinal cord disease
  • Neurodegenerative diseases
  • Congenital disorders
  • Neurogenetic disorders
  • Paraneoplastic syndromes
  • Peripheral nerve disease
  • Muscle diseases
• 27. Ear, nose and throat and eye disease
  • Core Skills and Knowledge
  • Introduction to ENT
  • Clinical approach to the patient with an ENT complaint
  • Disorders of the Ear
  • Clinical Approach to the Patient With a Disorder of the Ear
  • Common disorders of the ear
  • Disorders of the Nose
  • Clinical Approach to the Patient With a Disorder of the Nose
  • Common disorders of the nose
  • Disorders of the Throat
  • Clinical Approach to the Patient With a Disorder of the Throat
  • Common disorders of the throat
  • Disorders of the Eye
  • Applied Anatomy and Physiology
  • Clinical Approach to the Patient With a Disorder of the Eye
  • Common disorders of the eye
• 28. Respiratory disease
  • Core Skills and Knowledge
  • Clinical skills for respiratory medicine
  • Function of the respiratory system
  • Clinical Approach to the Patient with Respiratory Disease
  • Diseases of the Upper Respiratory Tract
  • Obstructive Respiratory Disease
  • Smoking
  • Respiratory Infection
  • Pleural Disease
  • Tumours of the Respiratory Tract
  • Bronchiectasis
  • Interstitial Lung Diseases
  • Lung and Heart–Lung Transplantation
  • Occupational Lung Disease
  • Miscellaneous Respiratory Disorders
  • Disorders of the Diaphragm
  • Mediastinal Lesions
• 29. Venous thromboembolic disease
  • Core Skills and Knowledge
  • Introduction
  • Pathogenesis of Thrombosis
  • Definitions
  • Epidemiology and Risk Factors
  • Clinical Features
  • Diagnosis
  • Management
  • Complications
  • Investigation of newly diagnosed venous thrombosis
  • Prevention
  • Anticoagulant agents
• 30. Cardiology
  • Core Skills and Knowledge
  • Clinical skills for cardiology
  • ECG interpretation
  • Anatomy, physiology and embryology of the heart
  • Clinical approach to the patient with heart disease
  • Therapeutic procedures
  • Cardiac arrhythmias
  • Bradycardias and heart block
  • Supraventricular tachycardias
  • Ventricular tachyarrhythmias
  • Heart failure
  • Coronary artery disease
  • Angina
  • Acute coronary syndromes
  • Valvular heart disease
  • Aortic valve
  • tricuspid valve
  • Pulmonary valve
  • Prosthetic valves
  • Infective endocarditis
  • Congenital heart disease
  • Marfan’s syndrome
  • Pulmonary heart disease
  • Myocardial and endocardial disease
  • Myocardial disease
  • Pericardial disease
  • Peripheral vascular disease
  • Peripheral venous disease
• 31. Hypertension
  • Core Skills and Knowledge
  • Introduction
  • Clinical Approach to the Patient with Hypertension
  • Measurement of blood pressure
  • Phenotypes of Hypertension
  • Causes of raised blood pressure
  • Thresholds and Targets In Hypertension
  • Hypertensive Target Organ Damage
  • Treatment
  • Managing blood pressure in hospital
• 32. Gastroenterology
  • Core Skills and Knowledge
  • Clinical Skills for Gastroenterology
  • INTRODUCTION
  • Anatomy and physiology of the gastrointestinal tract
  • Investigation of Gastrointestinal Disease
  • Functional Gastrointestinal Disorders
  • Mouth
  • Salivary Glands
  • Pharynx and Oesophagus
  • Stomach and Duodenum
  • Acute and Chronic Gastrointestinal Bleeding
  • Small Intestine
  • Inflammatory Bowel Disease
  • Colon and Rectum
  • The Acute Abdomen
  • Peritoneum
• 33. Nutrition
  • Core Skills and Knowledge
  • Introduction
  • Water and Electrolyte Balance
  • Dietary Requirements
  • Protein–Energy Malnutrition
  • Vitamins
  • Fat-soluble vitamins
  • Water-soluble vitamins
  • Dietary Antioxidants
  • Homocysteine, cardiovascular disease and B vitamins
  • Minerals
  • Nutrition and Ageing
  • Obesity
  • Nutritional Support
  • Food Allergy and Food Intolerance
  • Alcohol
• 34. Liver disease
  • Core Skills and Knowledge
  • Clinical skills for liver disease
  • Introduction
  • Anatomy of the liver and biliary system
  • Functions of the liver
  • Investigations in the patient with liver disease
  • Jaundice
  • Hepatitis
  • Acute hepatic failure
  • Autoimmune hepatitis
  • Drug-induced chronic hepatitis
  • Chronic hepatitis of unknown cause
  • Non-alcoholic fatty liver disease
  • Cirrhosis
  • Alcoholic liver disease
  • Budd–chiari syndrome
  • Hepatic sinusoidal obstruction syndrome
  • Fibropolycystic diseases
  • Liver abscess
  • Other infections of the liver
  • Liver disease in pregnancy
  • Liver tumours
  • Miscellaneous conditions of the liver
  • Drugs and the liver
• 35. Biliary tract and pancreatic disease
  • Core Skills and Knowledge
  • Introduction
  • Gall Bladder and Biliary System
  • Biliary system
  • Miscellaneous conditions of the biliary tract
  • Pancreas
  • Pancreatitis
  • Pancreatic cancer
  • Pancreatic neuroendocrine tumours
  • Clinical syndromes
  • Investigations
  • Management
• 36. Kidney and urinary tract disease
  • Core Skills and Knowledge
  • Clinical Skills for Nephrology
  • Examination
  • Introduction
  • Anatomy and Physiology of the Kidney and Urinary Tract
  • Investigation of Renal and Urinary Tract Disease
  • The Glomerulus and Glomerular Disease
  • Kidney Involvement in Other Diseases
  • Hypertension and the Kidney
  • Other Vascular Disorders of the Kidney
  • Renal Calculi and Nephrocalcinosis
  • Urinary Tract Obstruction
  • Drugs and the Kidney
  • Urinary Tract Infection
  • Tubulointerstitial Nephritis
  • Acute Kidney Injury
  • Chronic Kidney Disease
  • Cystic Renal Disease
  • Tumours of the Kidney and Genitourinary Tract
  • Diseases of the Prostate Gland
  • The Urinary Tract in the Elderly
• 37. Sexually transmitted infections and human immunodeficiency virus
  • Core Skills and Knowledge
  • Clinical skills for STI and HIV care
  • Sexually transmitted infections
  • Asymptomatic STI screening
  • Investigation of STIs
  • Management, prevention and control
  • Specific infections
  • Human immunodeficiency virus and acquired immunodeficiency syndrome
  • Clinical features of untreated hiv infection
  • Clinical approach to the patient with HIV
  • Management of HIV-positive patients
  • Specific conditions associated with HIV infection
  • Prevention and control of HIV infection
• 38. Obstetric medicine
  • Core Skills and Knowledge
  • Clinical Skills for Obstetric Medicine
  • Introduction
  • Hypertensive Disorders
  • Liver Disease
  • Cardiac Disease
  • Thromboembolic Disease
  • Respiratory Disease
  • Neurological Disease
  • Endocrine Disease
  • Renal Disease
  • Skin Disorders
  • RHEUMATIC DISEASE
  • Prescribing in Pregnancy
• 39. Women’s health
  • Core Skills and Knowledge
  • Clinical skills for women’s health
  • Introduction
  • The life course approach
  • Miscarriage
  • Heavy Menstrual Bleeding
  • Abortion/Termination of Pregnancy
  • Urinary Incontinence
  • Domestic abuse and violence
  • Gynaecological cancers
• 40. Men’s health
  • Core Skills and Knowledge
  • Clinical Skills For Men’s Health
  • Introduction
  • Specific Diseases of Men
  • Diseases of the prostate gland
  • Diseases of the Penis
  • Testicular and Spermatic Cord Disease
  • Lack of Libido and Erectile Dysfunction
  • Priapism
  • The Ageing Male
• 41. Environmental medicine
  • Core Skills and Knowledge
  • Air pollution
  • Heat Injury
  • Cold injury
  • High altitude
  • Diving
  • Drowning
  • Ionizing radiation
  • Electric shock
  • Lightning strike
  • Inhaled smoke
• Index
• Normal Values

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