Efnisyfirlit

• Cover
• Dedication Page
• Title Page
• Copyright Page
• Acknowledgments
• How to Use This Book
• About the Companion Website
• LECTURE 1: An Overview
  • INTRODUCTION
  • PHYSICAL BARRIERS
  • THE INNATE IMMUNE SYSTEM
  • THE ADAPTIVE IMMUNE SYSTEM
  • A COMPARISON OF THE INNATE AND ADAPTIVE IMMUNE SYSTEMS
  • THE INNATE SYSTEM RULES!
  • EPILOGUE
• LECTURE 2: The Innate Immune System
  • INTRODUCTION
  • THE COMPLEMENT SYSTEM
  • THE PROFESSIONAL PHAGOCYTES
  • HOW IMMUNE SYSTEM SENTINELS RECOGNIZE INVADERS
  • HOW THE INNATE IMMUNE SYSTEM DEALS WITH VIRUSES
  • THE INNATE IMMUNE SYSTEM – A COOPERATIVE EFFORT
  • A PROPORTIONAL RESPONSE
  • SUMMARY FIGURE
• LECTURE 3: B Cells and Antibodies
  • INTRODUCTION
  • THE B CELL RECEPTOR
  • HOW THE BCR SIGNALS
  • HOW B CELLS ARE ACTIVATED
  • CLASS SWITCHING
  • ANTIBODY CLASSES AND THEIR FUNCTIONS
  • SOMATIC HYPERMUTATION
  • B CELLS MAKE A CAREER CHOICE
  • SUMMARY FIGURE
• LECTURE 4: The Magic of Antigen Presentation
  • INTRODUCTION
  • CLASS I MHC MOLECULES
  • CLASS II MHC MOLECULES
  • ANTIGEN PRESENTATION BY CLASS I MHC MOLECULES
  • ANTIGEN PRESENTATION BY CLASS II MHC MOLECULES
  • ANTIGEN PRESENTING CELLS
  • THE LOGIC OF CLASS I MHC PRESENTATION
  • THE LOGIC OF CLASS II MHC PRESENTATION
  • CROSS‐PRESENTATION
  • NON‐CLASSICAL MHC MOLECULES AND LIPID PRESENTATION
  • MHC PROTEINS AND ORGAN TRANSPLANTS
  • SUMMARY FIGURE
• LECTURE 5: T Cell Activation
  • INTRODUCTION
  • T CELL RECEPTORS
  • HOW A T CELL’S RECEPTORS SIGNAL
  • CD4 AND CD8 CO‐RECEPTORS
  • CO‐STIMULATION
  • A TIME‐LAPSE PHOTO OF HELPER T CELL ACTIVATION
  • HOW KILLER T CELLS ARE ACTIVATED
• LECTURE 6: T Cells at Work
  • INTRODUCTION
  • HELPER T CELLS AS CYTOKINE FACTORIES
  • THE DENDRITIC CELL AS “COACH” OF THE IMMUNE SYSTEM TEAM
  • Th1 HELPER T CELLS
  • Th2 HELPER T CELLS
  • Th17 HELPER T CELLS
  • Th0 HELPER T CELLS
  • LOCKING IN THE HELPER T CELL PROFILE
  • DELAYED‐TYPE HYPERSENSITIVITY
  • HOW CTLs KILL
  • SUMMARY FIGURE
• LECTURE 7: Secondary Lymphoid Organs and Lymphocyte Trafficking
  • INTRODUCTION
  • LYMPHOID FOLLICLES
  • HIGH ENDOTHELIAL VENULES
  • LYMPH NODES
  • PEYER’S PATCHES
  • THE SPLEEN
  • THE LOGIC OF SECONDARY LYMPHOID ORGANS
  • LYMPHOCYTE TRAFFICKING
  • WHY MOTHERS KISS THEIR BABIES
• LECTURE 8: Restraining the Immune System
  • INTRODUCTION
  • ATTENUATING THE IMMUNE RESPONSE
  • DEACTIVATING THE SYSTEM
  • LIFE IS SHORT
  • EXHAUSTION
• LECTURE 9: Self Tolerance and MHC Restriction
  • INTRODUCTION
  • THE THYMUS
  • MHC RESTRICTION
  • THE LOGIC OF MHC RESTRICTION
  • THYMIC TESTING FOR TOLERANCE OF SELF
  • GRADUATION
  • THE RIDDLE OF MHC RESTRICTION AND TOLERANCE INDUCTION
  • TOLERANCE BY IGNORANCE
  • TOLERANCE INDUCTION IN SECONDARY LYMPHOID ORGANS
  • PERIPHERAL TOLERANCE INDUCTION
  • TOLERANCE DUE TO ACTIVATION‐INDUCED CELL DEATH
  • B CELL TOLERANCE
  • MAINTENANCE OF B CELL TOLERANCE IN GERMINAL CENTERS
  • THE EDUCATION OF NATURAL KILLER CELLS
• LECTURE 10: Immunological Memory
  • INTRODUCTION
  • INNATE MEMORY
  • ADAPTIVE MEMORY
  • PROPERTIES OF ADAPTIVE MEMORY CELLS
  • COMPARING B AND T CELL MEMORIES
  • INNATE VERSUS ADAPTIVE MEMORY
• LECTURE 11: The Intestinal Immune System
  • INTRODUCTION
  • INTESTINAL ARCHITECTURE
  • CHALLENGES FACED BY THE INTESTINAL IMMUNE SYSTEM
  • RESPONDING GENTLY TO LIMITED THREATS
  • THE INTESTINAL IMMUNE SYSTEM’S RESPONSE TO PATHOGENS
  • HOW TO RESPOND?
• LECTURE 12: The Immune System Gone Wrong
  • INTRODUCTION
  • DISEASES CAUSED BY DEFECTS IN IMMUNE REGULATION
  • AUTOIMMUNE DISEASE
• LECTURE 13: Immunodeficiency
  • INTRODUCTION
  • GENETIC DEFECTS LEADING TO IMMUNODEFICIENCY
  • AIDS
• LECTURE 14: Vaccines
  • INTRODUCTION
  • GENERATING MEMORY HELPER T AND B CELLS
  • GENERATING MEMORY KILLER T CELLS
  • STRATEGIES FOR VACCINE DEVELOPMENT
  • WILL THERE BE AN AIDS VACCINE?
  • VACCINATION TO PREVENT VIRUS‐ASSOCIATED CANCER
  • VACCINE ADJUVANTS
• LECTURE 15: Cancer and the Immune System
  • INTRODUCTION
  • CANCER IS A CONTROL SYSTEM PROBLEM
  • CLASSIFICATION OF CANCER CELLS
  • IMMUNE SURVEILLANCE AGAINST CANCER
  • IMMUNE SURVEILLANCE BY MACROPHAGES AND NK CELLS
• LECTURE 16: Immunotherapy
  • INTRODUCTION
  • IMMUNOTHERAPY USING MONOCLONAL ANTIBODIES
  • IMMUNOTHERAPY USING T CELLS
• LECTURE 17: COVID‐19 and the Immune System
  • INTRODUCTION
  • THE RESPIRATORY SYSTEM
  • SARS‐CoV‐2
  • THE IMMUNE RESPONSE TO RESPIRATORY VIRUSES
  • THE PATHOLOGY OF A SARS‐CoV‐2 INFECTION
  • THE mRNA VACCINE PLATFORM
  • mRNA VACCINATION VERSUS NATURAL INFECTION
  • CORRELATES OF PROTECTION
  • REINFECTION
  • VIRAL VARIANTS
• Glossary
• Acronyms and Abbreviations
• Index
• End User License Agreement

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