Efnisyfirlit

• Cover
• Title Page
• Copyright Page
• Dedication
• About the Author
• Preface
• Contents
• 1 Safety Practices and Quality in the Hematology Laboratory
  • An Overview of the Hematology Laboratory
  • Patient Safety
  • Safety in the Hematology Laboratory
  • Safe Work Practices and Protective Techniques for Infection Control
  • Quality Assessment in the Hematology Laboratory
  • Quality Control in the Hematology Laboratory
  • Chapter Highlights
  • Review Questions
  • References
  • Bibliography
• 2 Principles of Blood Collection
  • Quality in Blood Collection
  • Safe Blood Collection Equipment
  • Safe Blood Collection Equipment
  • Chapter Highlights
  • Review Questions
  • Case Studies
  • References
  • Bibliography
  • Internet Sites
• 3 Cellular Morphology and Foundations of Genetic Hematopoietic Disorders
  • Cellular Ultrastructure and Organization
  • Cellular Membranes
  • Cytoplasmic Organelles and Metabolites
  • Apoptosis
  • Chapter Highlights
  • Review Questions
  • Bibliography
• 4 Hematopoiesis
  • Ontogeny of Hematopoiesis
  • Hematopoietic Organs and Tissues
  • Secondary Lymphoid Tissues
  • Cellular Elements of Bone Marrow
  • Human Stem Cells
  • Cytokines
  • Examination of Maturing Blood Cells
  • Mature Blood Cells in Peripheral Blood
  • Chapter Highlights
  • Review Questions
  • Bibliography
• 5 Erythrocytes: Erythropoiesis, Maturation, Membrane Characteristics, and Metabolic Activities
  • Erythropoiesis
  • Disorders Related to Erythrocyte Maturation and Production
  • Membrane Characteristics and Metabolic Activities of Erythrocytes
  • Chapter Highlights
  • Case Study
  • Review Questions
  • Bibliography
• 6 Erythrocytes: Hemoglobin
  • Characteristics of Hemoglobin
  • Hemoglobin Function
  • Oxygen Dissociation and Alterations
  • Carbon Dioxide Transport
  • Biosynthesis of Hemoglobin
  • Disorders Related to Hemoglobin Biosynthesis
  • Ontogeny of Hemoglobin
  • Variant Forms of Normal Hemoglobin
  • Abnormal Hemoglobin Molecules
  • Analysis of Hemoglobin
  • Catabolism of Erythrocytes
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 7 Erythrocytes: Morphology and Inclusions
  • Erythrocytes: Normal and Abnormal
  • Types of Variations in Erythrocyte Size
  • Kinds of Variations in Erythrocyte Shape
  • Alterations in Erythrocyte Color
  • Varieties of Erythrocyte Inclusions
  • Alterations in Erythrocyte Distribution
  • Parasitic Inclusions in Erythrocytes
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 8 Leukocytes: The Granulocytic and Monocytic Series
  • Introduction
  • Granulocytic Series: Production of Neutrophils, Eosinophils, and Basophils
  • Granulocyte Sites of Development and Maturation
  • Distribution of Neutrophils, Eosinophils, and Basophils
  • Normal Maturational Characteristics of Granulocytes
  • Leukocyte Surface Markers
  • The Monocytic-Macrophage Series
  • Normal Reference Ranges and Variations
  • Abnormalities in Granulocytic Reference Ranges
  • Functional Properties of Monocytes/Macrophages
  • Phagocytosis
  • Chapter Highlights
  • Case Study
  • Review Questions
  • Bibliography
• 9 Leukocytes: Lymphocytes and Plasma Cells
  • Anatomical Origin and Development of Lymphocytes
  • Morphological Characteristics of Normal Lymphocytes
  • Characteristics of Lymphocytes
  • T Lymphocytes, B Lymphocytes, and Plasma Cell Kinetics
  • Plasma Cell Development and Maturation
  • Chapter Highlights
  • Review Questions
  • Bibliography
• 10 Basic Laboratory Assessment of Erythrocytes, Leukocytes, and Platelets
  • The Complete Blood Count
  • Quantitative Assessment of Erythrocytes
  • Quantitative Assessment of Leukocytes
  • Other Leukocyte-Related Assessments
  • Quantitative Assessment of Platelets
  • Peripheral Blood Film Evaluation
  • Semiquantitative Grading of Erythrocyte Morphology
  • Semiquantitative Assessment of Leukocytes
  • Semiquantitative Assessment of Platelets
  • Leukocyte Differential Count
  • Chapter Highlights
  • Review Questions
  • Bibliography
• 11 Classification and Laboratory Assessment of Anemias
  • Overview of Anemia
  • Development of Anemia
  • Clinical Signs and Symptoms of Anemia
  • Classification of Anemias
  • Laboratory Assessment of Anemias
  • Chapter Highlights
  • Review Questions
  • Bibliography
• 12 Acute and Chronic Blood Loss Anemia and Anemias Associated with Systemic Disorders
  • Acute Blood Loss Anemia
  • Chronic Blood Loss Anemia
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 13 Bone Marrow Failure Syndromes
  • Bone Marrow Failure Syndromes
  • Acquired Aplastic Anemia
  • Constitutional Bone Marrow Failure Syndromes Associated with Aplastic Anemia
  • Bone Marrow Failures Involving a Single-Cell Lineage
  • Congenital Amegakaryocytic Thrombocytopenia
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 14 Disorders of Iron Metabolism and Heme Synthesis
  • Iron Deficiency and Iron Overload
  • Iron Deficiency and Iron Deficiency Anemia
  • Iron Deficiency Anemia
  • Anemia of Inflammation or Anemia of Chronic Disorders/Diseases
  • Disorders Related to Hemoglobin Biosynthesis: Sideroblastic Anemia
  • Disorders Related to Hemoglobin Biosynthesis: Hereditary Hemochromatosis
  • Disorders Related to Hemoglobin Biosynthesis: Heme (Porphyrin) Synthesis
  • Disorders Related to Hemoglobin Biosynthesis: Disorders of Globulin Synthesis
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 15 Macrocytic and Megaloblastic Anemias
  • Macrocytic Anemias
  • Megaloblastic Anemias
  • Pernicious Anemia
  • Folic Acid Deficiency Anemia
  • Chapter Highlights
  • Case Study
  • Review Questions
  • Bibliography
• 16 Hemolytic Anemias
  • Hemolytic Anemias
  • The Role of Complement in Hemolytic Anemia
  • Complement-Mediated Disease
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 17 Hemoglobinopathies and Thalassemias
  • Hemoglobin Defects
  • Sickle Cell Disease
  • Sickle Cell Syndromes: Pathogenesis and New Approaches
  • Thalassemia
  • Other Hemoglobinopathies
  • Hereditary Persistence of Fetal Hemoglobin
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 18 Disorders of Granulocytes and Monocytes
  • Granulopoietic Alterations: Quantitative Disorders
  • Morphological Abnormalities of Mature Granulocytes
  • Inherited Functional Abnormalities
  • Granulopoietic Alterations: Qualitative Disorders
  • Monocyte-Macrophage Disorders
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 19 Disorders of Lymphocytes
  • Characteristics of Lymphocytes
  • Lymphocytosis
  • Disorders Associated with Lymphocytosis
  • Lymphocytopenia
  • Immune Disorders Associated with Lymphocytopenia
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 20 Characteristics of Leukemias, Lymphomas, and Myelomas
  • Comparison of Leukemias, Lymphomas, and Myelomas
  • Forms of Leukemia
  • Classifications of Leukemias
  • Prognosis and Treatment
  • Factors Related to the Occurrence of Leukemia
  • Demographic Distribution of Leukemia and Lymphomas
  • Leukemia Vaccines
  • Chapter Highlights
  • Review Questions
  • Bibliography
• 21 Acute Leukemias
  • General Characteristics of Acute Leukemias
  • Acute Myeloid Leukemias
  • Prognosis of AML
  • Treatment Options
  • Acute Lymphoblastic Leukemia
  • Prognosis of ALL
  • Life-Threatening Emergencies
  • Future Trends: Vaccines
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 22 Lymphoid and Plasma Cell Neoplasms
  • Leukemias versus Lymphomas
  • Chronic Lymphocytosis
  • T-Cell and NK-Cell Neoplasms
  • Lymphomas
  • Hodgkin Disease
  • Plasma Cell Dyscrasias
  • Immune Approaches
  • Waldenström Primary Macroglobulinemia (Lymphoplasmacytic Lymphoma)
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 23 Myeloproliferative Neoplasms
  • General Characteristics of Myeloproliferative Neoplasms
  • Chronic Myelogenous Leukemia
  • Polycythemia Vera, Essential Thrombocytosis (Essential Thrombocythemia), and Primary Myelofibrosis
  • Polycythemia Vera
  • Primary Myelofibrosis
  • Essential Thrombocytosis/Essential Thrombocythemia
  • Mastocytosis
  • Myeloproliferative Neoplasm, Unclassifiable (MPN-U)
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 24 Myelodysplastic Syndromes and Myelodysplastic/Myeloproliferative Neoplasms
  • General Characteristics of Myelodysplastic Syndrome and Myelodysplastic/Myeloproliferative Neoplasms
  • Myelodysplastic Syndromes
  • Relationship of Cytogenetics to Prognosis
  • Treatment Strategies
  • Myelodysplastic Syndromes/Myeloproliferative Neoplasms (MDS/MPN)
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 25 Principles of Hemostasis and Thrombosis: Vasculature and Platelets
  • Overview of Hemostasis and Thrombosis
  • Blood Vasculature: Structure and Function
  • Vasculature Physiology
  • Thrombopoiesis
  • Cell-Based Mechanism of Hemostasis: Platelet Function
  • Chapter Highlights
  • Review Questions
  • Bibliography
• 26 Disorders of Primary Hemostasis and Thrombosis Vasculature and Platelets
  • Vascular Abnormalities
  • Quantitative Platelet Disorders
  • Qualitative Characteristics of Platelets: Thrombocytopathy/Thrombocythemia
  • Chapter Highlights
  • Case Study
  • Review Questions
  • Bibliography
• 27 Principles of Hemostasis and Thrombosis: Blood Coagulation Factors and Natural Coagulant Systems
  • Blood Coagulation Factors
  • Normal Protective Mechanisms against Thrombosis
  • Modern View of Hemostasis
  • Chapter Highlights
  • Review Questions
  • Bibliography
• 28 Disorders of Hemostasis and Thrombosis: Blood Coagulation Factors, Hypercoagulable State, and Anticoagulant Therapy
  • Introduction
  • Defective Production
  • Disorders of Destruction and Consumption
  • The Hypercoagulable (Thrombophilia)
  • Anticoagulant Therapy
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 29 Body Fluid Analysis
  • Introduction
  • Cerebrospinal Fluid
  • Pleural, Peritoneal, and Pericardial Fluids
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 30 Instrumentation in Hematology
  • Instrumental Principles
  • Whole Blood Cell Analysis
  • Analysis of Instrumental Data Output
  • Laser Technology
  • Applications of Flow Cytometry
  • Digital Microscopy
  • Instruments in Coagulation Studies
  • Chapter Highlights
  • Case Studies
  • Review Questions
  • Bibliography
• 31 Molecular Diagnostic Techniques and Applications
  • The Human Genome Project
  • Molecular Techniques in Hematology
  • Molecular Genetics in Hematology
  • Chapter Summary
  • Review Questions
  • Bibliography
• 32 Laboratory Manual: Manual Procedures in Hematology
  • Procedural Format
  • Review Questions
• A Answers to Review Questions
• B Frequently Used Abbreviations
• C Safety Data Sheets
• D Tube Guide BD
• E Tube Guide Greiner
• F Interleukins
• G The Microscope
• H Quick References
• Glossary
• Index

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